List of works - Andries C. Bloem

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect.

scientific article

A class II-restricted cytotoxic T-cell clone recognizes a human minor histocompatibility antigen with a restricted tissue distribution.

scientific article

A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease

scientific article published on 02 August 2019

A novel flow cytometric assay for the quantification of adhesion of subsets within a heterogeneous cell population; analysis of lymphocyte function-associated antigen-1 (LFA-1)-mediated binding of bone marrow-derived primary tumour cells of patients

scientific article published on 01 September 1993

Adhesion molecules: a new target for immunoliposome-mediated drug delivery

scientific article published on January 1995

Adhesion of subsets of human blood mononuclear cells to endothelial cells in vitro, as quantified by flow cytometry

scientific article published on 01 December 1992

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

scientific article published on 03 July 2018

Anti-adhesive signals are mediated via major histocompatibility complex class II molecules in normal and neoplastic human B cells: correlation with B cell differentiation stage

scientific article

Antigens shared by malignant plasma cells and normal B cells may be involved in graft versus myeloma

scientific article published on February 2003

Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study

scientific article published on January 2015

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

scientific article published on 24 December 2011

CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma

scientific article published on 15 June 2016

CD44 isoforms are differentially regulated in plasma cell dyscrasias and CD44v9 represents a new independent prognostic parameter in multiple myeloma

scientific article published on 01 December 2001

CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease

scientific article published on 01 November 1998

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

scientific article published on 01 January 2002

CT screening for pulmonary pathology in common variable immunodeficiency disorders and the correlation with clinical and immunological parameters

scientific article published on 21 June 2014

Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

scientific article published on 15 March 2018

Changes in lymphocyte subsets in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

scientific article published in January 2003

Co-ligation of ICAM-1 (CD54) and membrane IgM negatively affects B cell receptor signaling

scientific article published on January 1995

Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group

scientific article published on 01 July 2000

Continuous low-dose cyclophosphamide-prednisone is effective and well tolerated in patients with advanced multiple myeloma

scientific article published in August 2001

Cytogenetic aberrations in neuropathy associated with IgM monoclonal gammopathy

scientific article published on 01 June 2007

Defective calcium signaling and disrupted CD20-B-cell receptor dissociation in patients with common variable immunodeficiency disorders.

scientific article published on 30 November 2011

Detection of choroid- and retina-antigen reactive CD8(+) and CD4(+) T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy

scientific article published on 12 February 2014

Different CD44 splicing patterns define prognostic subgroups in multiple myeloma

scientific article published on 01 October 1996

Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells

scientific article published on January 1994

Donor leukocyte infusions inducing remissions repeatedly in a patient with recurrent multiple myeloma after allogeneic bone marrow transplantation

scientific article published on 01 January 1999

Dose-finding study of high-dose simvastatin combined with standard chemotherapy in patients with relapsed or refractory myeloma or lymphoma.

scientific article

Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts.

scientific article published in June 2003

Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients

scientific article published on 26 September 2019

Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen

scientific article published on 09 November 2010

Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

scientific article published on 12 October 2016

Expression of members of the immunoglobulin VH3 gene families is not restricted at the level of individual genes in human chronic lymphocytic leukemia

scientific article published on March 1, 1992

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.

scientific article published in January 1998

Functional properties of human B cell subpopulations defined by monoclonal antibodies HB4 and FMC7

scientific article published on 01 February 1988

G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma

scientific article published in June 2004

Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity

scientific article published on 21 November 2003

Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.

scientific article published in January 2005

Graft versus myeloma may overcome the unfavorable effect of deletion of chromosome 13 in multiple myeloma

scientific article published on 01 February 2003

Growth factors and antiapoptotic signaling pathways in multiple myeloma

scientific article

High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma

scientific article published in December 2007

Host cell membrane proteins on human immunodeficiency virus type 1 after in vitro infection of H9 cells and blood mononuclear cells. An immuno-electron microscopic study

scientific article published on January 1993

Human follicular dendritic cells: isolation and characteristics in situ and in suspension

scientific article

Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines

scientific article published on June 1999

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

scientific article

Immune reconstitution in children following chemotherapy for haematological malignancies: a long-term follow-up

scientific article published on 28 November 2010

Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy

scientific article published on 06 March 2006

Immunoglobulin production by human peripheral lymphocytes induced by anti-C3 receptor antibodies ⬇️

scientific article published on 01 March 1984

Impact of treatment reduction for childhood acute lymphoblastic leukemia on serum immunoglobulins and antibodies against vaccine-preventable diseases

scientific article published on 25 July 2011

Inability of a monoclonal anti-light chain antibody to detect clonal plasma cells in a patient with multiple myeloma by multicolor flow cytometry

scientific article published on 27 September 2012

Inability of monoclonal anti-light chain antibody to detect clonal B-cells in a patient with follicular lymphoma by multicolor flow cytometry.

scientific article published on 22 March 2014

Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

scientific article

Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma

scientific article

Lenalidomide combined with low-dose cyclophosphamide and prednisone modulates Ikaros and Aiolos in lymphocytes, resulting in immunostimulatory effects in lenalidomide-refractory multiple myeloma patients

Lethal neonatal bone marrow failure syndrome with multiple congenital abnormalities including limb defects due to a constitutional deletion of 3' MECOM.

scientific article published on 8 February 2018

Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells

scientific article published on 01 November 1985

Long-term bone marrow cultured stromal cells regulate myeloma tumour growth in vitro: studies with primary tumour cells and LTBMC-dependent cell lines

scientific article published on 01 January 1998

Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma

scientific article published on 01 February 1998

Lymphoblastic lymphoma with a triple-hit profile: a rare but distinct and relevant entity.

scientific article published on 17 November 2016

Lymphocyte characteristics in children with common variable immunodeficiency

scientific article published on 16 December 2009

Lymphocyte function-associated antigen-1 expression on plasma cells correlates with tumor growth in multiple myeloma

scientific article published on 01 April 1992

Malignant transformation of monoclonal gammopathy of undetermined significance: cumulative incidence and prognostic factors.

scientific article

Measurement of pneumococcal polysaccharide vaccine responses for immunodeficiency diagnostics: combined IgG responses compared to serotype specific IgG responses.

scientific article published on 24 July 2013

Mitogenic stimulation of malignant B cells CLL: diminished in-vitro stimulation with anti-CR1 antibodies

scientific article published on 01 January 1988

Mitogenic stimulation of malignant B cells Waldenstrøm's macroglobulinaemia: secretion of monoclonal IgM by in vitro-induced plasmablasts

scientific article published on 01 January 1986

Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype

scientific article published on 01 November 1982

Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: secretion of monoclonal IgM by in vitro-induced plasmablasts

scientific article published on 01 March 1984

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

scientific article

Multiple ICAM-1 (CD54) epitopes are involved in homotypic B-cell adhesion

scientific article published on May 1, 1992

New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway

scientific article

Novel data analysis method for multicolour flow cytometry links variability of multiple markers on single cells to a clinical phenotype.

scientific article published on 14 July 2017

Phase 1/2 study of lenalidomide combined with low-dose cyclophosphamide and prednisone in lenalidomide-refractory multiple myeloma

scientific article

Phase I/II study of sequential chemoimmunotherapy (SCIT) for metastatic melanoma: outpatient treatment with dacarbazine, granulocyte-macrophage colony-stimulating factor, low-dose interleukin-2, and interferon-alpha

scientific article published on 15 October 2002

Phenotypical and functional characterization of the idiotype-positive blood B cells in multiple myeloma

scientific article published on 01 December 1988

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

scientific article published on October 1994

Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells

scientific article published on November 2003

Rapid identification of clinical relevant minor histocompatibility antigens via genome-wide zygosity-genotype correlation analysis

scientific article published on 24 November 2009

Rebuilding human leukocyte antigen class II-restricted minor histocompatibility antigen specificity in recall antigen-specific T cells by adoptive T cell receptor transfer: implications for adoptive immunotherapy.

scientific article

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

Reduced versus intensive chemotherapy for childhood acute lymphoblastic leukemia: impact on lymphocyte compartment composition

scientific article published on 3 November 2010

Salivary immune responses to the 7-valent pneumococcal conjugate vaccine in the first 2 years of life

scientific article

Selective in vitro expansion and efficient retroviral transduction of human CD34+ CD38- haematopoietic stem cells

scientific article

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.

scientific article

Susceptibility of malignant plasma cells to HA-1(H) specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect

scientific article published on 01 September 2004

Synergy in B-Cell Activation between Toll-Like Receptor 9 and Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor (TACI) in A181E/C104R Compound Heterozygous Siblings

T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor

scientific article published on 01 January 1986

T cells in B cell chronic lymphocytic leukemia. II. Lack of antigen-specific T suppressor cells and their progenitors

scientific article published on 01 December 1985

The SCID mouse as a model for multiple myeloma

scientific article published on 01 February 1995

The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells

scientific article published in July 2002

The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

scientific article published in April 2003

Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis

scientific article published on 10 November 2008

Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab.

scientific article published on 15 May 2015

List of works by Andries C. Bloem

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect.

A class II-restricted cytotoxic T-cell clone recognizes a human minor histocompatibility antigen with a restricted tissue distribution.

A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease

A novel flow cytometric assay for the quantification of adhesion of subsets within a heterogeneous cell population; analysis of lymphocyte function-associated antigen-1 (LFA-1)-mediated binding of bone marrow-derived primary tumour cells of patients

Adhesion molecules: a new target for immunoliposome-mediated drug delivery

Adhesion of subsets of human blood mononuclear cells to endothelial cells in vitro, as quantified by flow cytometry

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

Anti-adhesive signals are mediated via major histocompatibility complex class II molecules in normal and neoplastic human B cells: correlation with B cell differentiation stage

Antigens shared by malignant plasma cells and normal B cells may be involved in graft versus myeloma

Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma

CD44 isoforms are differentially regulated in plasma cell dyscrasias and CD44v9 represents a new independent prognostic parameter in multiple myeloma

CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

CT screening for pulmonary pathology in common variable immunodeficiency disorders and the correlation with clinical and immunological parameters

Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

Changes in lymphocyte subsets in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

Co-ligation of ICAM-1 (CD54) and membrane IgM negatively affects B cell receptor signaling

Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group

Continuous low-dose cyclophosphamide-prednisone is effective and well tolerated in patients with advanced multiple myeloma

Cytogenetic aberrations in neuropathy associated with IgM monoclonal gammopathy

Defective calcium signaling and disrupted CD20-B-cell receptor dissociation in patients with common variable immunodeficiency disorders.

Detection of choroid- and retina-antigen reactive CD8(+) and CD4(+) T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy

Different CD44 splicing patterns define prognostic subgroups in multiple myeloma

Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells

Donor leukocyte infusions inducing remissions repeatedly in a patient with recurrent multiple myeloma after allogeneic bone marrow transplantation

Dose-finding study of high-dose simvastatin combined with standard chemotherapy in patients with relapsed or refractory myeloma or lymphoma.

Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts.

Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients

Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen

Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

Expression of members of the immunoglobulin VH3 gene families is not restricted at the level of individual genes in human chronic lymphocytic leukemia

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.

Functional properties of human B cell subpopulations defined by monoclonal antibodies HB4 and FMC7

G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma

Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity

Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.

Graft versus myeloma may overcome the unfavorable effect of deletion of chromosome 13 in multiple myeloma

Growth factors and antiapoptotic signaling pathways in multiple myeloma

High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma

Host cell membrane proteins on human immunodeficiency virus type 1 after in vitro infection of H9 cells and blood mononuclear cells. An immuno-electron microscopic study

Human follicular dendritic cells: isolation and characteristics in situ and in suspension

Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

Immune reconstitution in children following chemotherapy for haematological malignancies: a long-term follow-up

Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy

Immunoglobulin production by human peripheral lymphocytes induced by anti-C3 receptor antibodies ⬇️

Impact of treatment reduction for childhood acute lymphoblastic leukemia on serum immunoglobulins and antibodies against vaccine-preventable diseases

Inability of a monoclonal anti-light chain antibody to detect clonal plasma cells in a patient with multiple myeloma by multicolor flow cytometry

Inability of monoclonal anti-light chain antibody to detect clonal B-cells in a patient with follicular lymphoma by multicolor flow cytometry.

Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma

Lenalidomide combined with low-dose cyclophosphamide and prednisone modulates Ikaros and Aiolos in lymphocytes, resulting in immunostimulatory effects in lenalidomide-refractory multiple myeloma patients

Lethal neonatal bone marrow failure syndrome with multiple congenital abnormalities including limb defects due to a constitutional deletion of 3' MECOM.

Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells

Long-term bone marrow cultured stromal cells regulate myeloma tumour growth in vitro: studies with primary tumour cells and LTBMC-dependent cell lines

Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma

Lymphoblastic lymphoma with a triple-hit profile: a rare but distinct and relevant entity.

Lymphocyte characteristics in children with common variable immunodeficiency

Lymphocyte function-associated antigen-1 expression on plasma cells correlates with tumor growth in multiple myeloma

Malignant transformation of monoclonal gammopathy of undetermined significance: cumulative incidence and prognostic factors.

Measurement of pneumococcal polysaccharide vaccine responses for immunodeficiency diagnostics: combined IgG responses compared to serotype specific IgG responses.

Mitogenic stimulation of malignant B cells CLL: diminished in-vitro stimulation with anti-CR1 antibodies

Mitogenic stimulation of malignant B cells Waldenstrøm's macroglobulinaemia: secretion of monoclonal IgM by in vitro-induced plasmablasts

Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype

Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: secretion of monoclonal IgM by in vitro-induced plasmablasts

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Multiple ICAM-1 (CD54) epitopes are involved in homotypic B-cell adhesion

New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway

Novel data analysis method for multicolour flow cytometry links variability of multiple markers on single cells to a clinical phenotype.

Phase 1/2 study of lenalidomide combined with low-dose cyclophosphamide and prednisone in lenalidomide-refractory multiple myeloma

Phase I/II study of sequential chemoimmunotherapy (SCIT) for metastatic melanoma: outpatient treatment with dacarbazine, granulocyte-macrophage colony-stimulating factor, low-dose interleukin-2, and interferon-alpha

Phenotypical and functional characterization of the idiotype-positive blood B cells in multiple myeloma

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells

Rapid identification of clinical relevant minor histocompatibility antigens via genome-wide zygosity-genotype correlation analysis

Rebuilding human leukocyte antigen class II-restricted minor histocompatibility antigen specificity in recall antigen-specific T cells by adoptive T cell receptor transfer: implications for adoptive immunotherapy.