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Authors whose works are in public domain in at least one jurisdiction

List of works by Tuna Mutis

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization.

scientific article published on 13 May 2017

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect.

scientific article

A class II-restricted cytotoxic T-cell clone recognizes a human minor histocompatibility antigen with a restricted tissue distribution.

scientific article

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

scientific article (publication date: 15 November 2014)

A phase I/II minor histocompatibility antigen-loaded dendritic cell vaccination trial to safely improve the efficacy of donor lymphocyte infusions in myeloma

scientific article published on 05 June 2017

Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance.

scientific article published on 4 September 2013

Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes

scientific article published on 13 October 2014

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

scientific article

Application of cultured human regulatory T cells requires preclinical in vivo evaluation

scientific article published in March 2012

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes

scientific article published on 18 March 2004

Bone marrow provides an environment that prevents suppression of therapeutic graft-vs.-tumor immunity by regulatory T cells

scientific article published on 30 April 2013

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

scientific article published on 21 February 2019

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia

scientific article published on 06 September 2018

CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma

scientific article published on 15 June 2016

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

scientific article published on 30 December 2020

CD38-targeting antibodies in multiple myeloma: mechanisms of action and clinical experience

scientific article published on 21 February 2018

CD80-Transfected acute myeloid leukemia cells induce primary allogeneic T-cell responses directed at patient specific minor histocompatibility antigens and leukemia-associated antigens ⬇️

scientific article published on September 1, 1998

Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

scientific article published on 15 March 2018

Challenges for Immunotherapy in Multiple Myeloma: Bone Marrow Microenvironment-Mediated Immune Suppression and Immune Resistance

scientific article published on 17 April 2020

Characterization of the Toll-like receptor expression profile in human multiple myeloma cells

scientific article

Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells

scientific article published on 12 April 2019

Comparison of intramedullary myeloma and corresponding extramedullary soft tissue plasmacytomas using genetic mutational panel analyses

scientific article published on 20 May 2016

Competition-based cellular peptide binding assay for HLA class I.

scientific article published on September 2004

Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides

scientific article published on February 2003

Complete Tumor Regression by Liposomal Bortezomib in a Humanized Mouse Model of Multiple Myeloma

scientific article published on 27 August 2020

Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1.

scientific article

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

scientific article

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

scientific article

Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

scientific article published on 15 December 2014

Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab

scientific article published on 26 May 2020

Detection of choroid- and retina-antigen reactive CD8(+) and CD4(+) T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy

scientific article published on 12 February 2014

Development of anti-CD32b antibodies with enhanced Fc function for the treatment of B and plasma cell malignancies

scientific article published on 26 August 2020

Diagnosis, risk stratification and management of monoclonal gammopathy of undetermined significance and smoldering multiple myeloma

scientific article

Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment

scientific article published on 05 August 2020

DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

scientific article published on 28 April 2020

Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients

scientific article published on 26 September 2019

Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients

scientific article published on 14 November 2016

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA

scientific article published on 01 January 2002

Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells

scientific article

Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen

scientific article published on 09 November 2010

Escherichia coli-nitroreductase suicide gene control of human telomerase reverse transcriptase-transduced minor histocompatibility antigen-specific cytotoxic T cells

scientific article published in May 2004

Exclusive TCRVβ chain usage of ex vivo generated minor Histocompatibility antigen HA-1 specific cytotoxic T cells: implications for monitoring of immunotherapy of leukemia by TCRBV spectratyping

scientific article published on 01 January 2002

Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies

scientific article published on 19 October 2020

Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design.

scientific article

Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4(+)CD25(-) cells

scientific article published on 01 May 2008

General T-cell receptor antagonists to immunomodulate HLA-A2-restricted minor histocompatibility antigen HA-1-specific T-cell responses

scientific article published on February 2002

Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation

scientific article

Graft-versus-host driven graft-versus-leukemia effect of minor histocompatibility antigen HA-1 in chronic myeloid leukemia patients

scientific article published on 27 May 2010

HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand

scientific article

HLA class II restricted T-cell reactivity to a developmentally regulated antigen shared by leukemic cells and CD34+ early progenitor cells ⬇️

scientific article published on August 1, 1997

HY antibodies as biomarkers for chronic GVHD

scientific article published on 01 May 2015

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

scholarly article

Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies

scientific article

High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action

scientific article published on 11 December 2018

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells ⬇️

scientific article published on February 4, 2013

Human regulatory T cells control xenogeneic graft-versus-host disease induced by autologous T cells in RAG2-/-gammac-/- immunodeficient mice

scientific article published on 01 September 2006

Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation

scientific article published on 01 August 2003

Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus

scientific article published on September 2002

Identification of minor histocompatibility antigens based on the 1000 Genomes Project

scientific article

Immunotherapy in myeloma: how far have we come?

scientific article published on 18 January 2019

Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma.

scientific article published on 7 February 2018

Impact of MYC on Anti-Tumor Immune Responses in Aggressive B Cell Non-Hodgkin Lymphomas: Consequences for Cancer Immunotherapy

scientific article published on 20 October 2020

In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

scientific article published on 01 April 2002

Interleukin-17 production and T helper 17 cells in peripheral blood mononuclear cells in response to ocular lysate in patients with birdshot chorioretinopathy

scientific article

Intraocular interleukin-17 and proinflammatory cytokines in HLA-A29-associated birdshot chorioretinopathy

scientific article (publication date: August 2011)

Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4+Foxp3+ T cells.

scientific article

Lenalidomide combined with low-dose cyclophosphamide and prednisone modulates Ikaros and Aiolos in lymphocytes, resulting in immunostimulatory effects in lenalidomide-refractory multiple myeloma patients

Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial

scientific article published on 20 June 2011

Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma

scientific article published on 22 January 2019

Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance

scientific article

Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives

scientific article

Monoclonal antibodies targeting CD38 in hematological malignancies and beyond

scientific article

Monoclonal antibody-based therapy as a new treatment strategy in multiple myeloma

scientific article published on 19 August 2011

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

scientific article

Outcome of allogeneic transplantation in newly diagnosed and relapsed/refractory multiple myeloma: long-term follow-up in a single institution

scientific article

Phase 1/2 study of lenalidomide combined with low-dose cyclophosphamide and prednisone in lenalidomide-refractory multiple myeloma

scientific article

Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells

scientific article published on 01 July 1999

Potent Preclinical Efficacy of DuoHexaBody-CD37 in B-Cell Malignancies

scientific article published on 09 December 2020

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma.

scientific article published on 8 February 2016

Preclinical Activity of JNJ-7957, a Novel BCMA×CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab

scientific article published on 22 January 2020

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

scientific article

Preclinical Rationale for Targeting the PD-1/PD-L1 Axis in Combination with a CD38 Antibody in Multiple Myeloma and Other CD38-Positive Malignancies

scientific article published on 10 December 2020

Preclinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

scientific article published on 4 November 2015

Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma

scientific article published on 31 January 2020

Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy

scientific article published on 30 October 2003

Rapid identification of clinical relevant minor histocompatibility antigens via genome-wide zygosity-genotype correlation analysis

scientific article published on 24 November 2009

Rebuilding human leukocyte antigen class II-restricted minor histocompatibility antigen specificity in recall antigen-specific T cells by adoptive T cell receptor transfer: implications for adoptive immunotherapy.

scientific article

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.

scientific article published on 7 December 2009

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

scientific article published on 19 May 2016

Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance.

scientific article published on 5 May 2016

T Cells Specific for an Unconventional Natural Antigen Fail to Recognize Leukemic Cells

scientific article published on 19 March 2019

T cells from the small intestinal mucosa of coeliac disease patients recognize a unique peptide sequence of gliadin

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma

scientific article published on 10 November 2020

TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes

scientific article published on September 2007

Targeted Therapy With Immunoconjugates for Multiple Myeloma

scientific article published on 19 June 2020

Targeting Alloreactive Donor T-Cells to Hematopoietic System-Restricted Minor Histocompatibility Antigens to Dissect Graft-versus-Leukemia Effects from Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation ⬇️

scientific article published on October 1, 2003

Targeting alloreactive T cells to hematopoietic system specific minor histocompatibility antigens for cellular immunotherapy of hematological malignancies after stem cell transplantation.

scientific article

Targeting haematopoietic-specific minor histocompatibility antigens to distinguish graft-versus-tumour effects from graft-versus-host disease

scientific article published on September 2008

Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

scientific article published on 01 July 1999

The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction

scientific article published on 24 June 2020

The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein.

scientific article

The association of CD25 expression on donor CD8+ and CD4+ T cells with graft-versus-host disease after donor lymphocyte infusions

scientific article published on 01 October 2005

The impact of circulating suppressor cells in multiple myeloma patients on clinical outcome of DLIs.

scientific article published on 23 March 2015

The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies

scientific article published on 28 October 2011

Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis

scientific article (publication date: 2014)

Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis

scientific article published on 10 November 2008

Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1.

scientific article published on October 2012

Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab

scientific article published on 25 November 2010

Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab.

scientific article published on 15 May 2015

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