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List of works by Chad A. Cowan

A TALEN genome-editing system for generating human stem cell-based disease models

scientific article published on 13 December 2012

A coagulation defect arising from heterozygous premature termination of tissue factor

scientific article published on 14 July 2020

A comparison of non-integrating reprogramming methods

scientific article

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface

scientific article published on 13 April 2016

A high-efficiency system for the generation and study of human induced pluripotent stem cells

scientific article

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease

scientific article

Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics

scientific article published on 06 May 2019

Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan

scientific article published on 28 May 2016

Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

scientific article published on 01 July 2020

An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection

article

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells

scientific article published on May 2016

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development

scientific journal article

Cbx Proteins Help ESCs Walk the Line between Self-Renewal and Differentiation ⬇️

scientific article published on January 6, 2012

Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells

scientific article

Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

scientific article (publication date: 25 March 2004)

Differentiation of white and brown adipocytes from human pluripotent stem cells

scientific article published on January 2014

Disease-specific induced pluripotent stem cells

scientific article

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

scientific article

Efficient culturing and genetic manipulation of human pluripotent stem cells

scientific article

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

scientific article published on April 2013

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development

scientific article

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Expression Analysis of Macrodactyly Identifies Pleiotrophin Upregulation ⬇️

scientific article published on July 27, 2012

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism

scientific article published on 3 November 2017

Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro

scientific article published on 09 October 2020

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

scientific article

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

scientific article published on 19 November 2019

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

scientific article published on 01 November 2019

Gene expression in the preimplantation embryo: in-vitro developmental changes

scientific article published in May 2005

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs ⬇️

scientific article published on April 6, 2012

Generation of hypoimmunogenic human pluripotent stem cells

scientific article published on 30 April 2019

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

scientific article

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions

scientific article

Genome editing for human gene therapy.

scientific article

Genome editing in human pluripotent stem cells

scientific article published on 21 June 2013

Genome modification in human embryonic stem cells

scientific article published on February 2010

Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report

scientific article published on 5 November 2015

Genome-wide chromatin state transitions associated with developmental and environmental cues

scientific article

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

scientific article published in October 2008

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

scientific article published on 06 May 2020

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

scientific article

Human embryonic stem cells

scientific article published on 01 January 2006

Human embryonic stem cells: emerging technologies and practical applications

scientific article published on 30 July 2008

Humanity in a Dish: Population Genetics with iPSCs

scientific article published on 17 October 2017

Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance

scientific article published on 03 March 2020

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

scientific article

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

scientific article published on April 2017

Induced pluripotent stem (iPS) cells: an up-to-the-minute review ⬇️

scientific article published on November 16, 2009

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells

scientific article published on 05 August 2020

Interactomics Analyses of Wild-type and Mutant A1CF Reveal Diverged Functions in Regulating Cellular Lipid Metabolism

scientific article published on 10 August 2020

Liver in a dish

scientific article

Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

scientific article published in August 2014

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

scientific article

Marked differences in differentiation propensity among human embryonic stem cell lines

scientific article published on 17 February 2008

Microenvironmental Control of Adipocyte Fate and Function.

scientific article

Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease.

scientific article published on 13 April 2016

Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes

scientific article published on 01 April 2020

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype ⬇️

scientific article published on 09 December 2019

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

scientific article published on January 2013

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment

scientific article

New tools for genome modification in human embryonic stem cells

scientific article published on December 2007

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells

scientific article

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

scientific article published on 4 August 2017

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines

scientific article published in February 2009

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

scientific article published on 12 May 2020

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

scientific article published on 01 July 2020

Pattern Specification and Immune Response Transcriptional Signatures of Pericardial and Subcutaneous Adipose Tissue ⬇️

scientific article published on October 11, 2011

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

scientific article

Programming human pluripotent stem cells into white and brown adipocytes.

scientific article

Rapid cellular turnover in adipose tissue

scientific article

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

scientific article published on 01 August 2018

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.

scientific article published on 21 September 2017

Severe insulin resistance alters metabolism in mesenchymal progenitor cells

scientific article published on 26 March 2015

TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection

scientific article published on 3 August 2015

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics

scientific article published in April 2017

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal

scientific article published on 17 May 2004

Type 1 Diabetes and MicroRNA: It's Complicated.

scientific article

Utility of CRISPR/Cas9 systems in hematology research

scientific article published on 28 June 2017

White to brite adipocyte transition and back again

scientific article published in June 2013

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

scientific article published on 8 December 2014

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors

scientific article

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