List of works - Gregory J. Cooney

A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster

scientific article published on 06 August 2019

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

scientific article published in Nature Communications

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

scientific article published on 16 September 2013

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

scientific article published in October 2002

AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo

scientific article

AMP-activated protein kinase and muscle insulin resistance

scientific article published on January 2009

Ablation of Grb10 specifically in muscle impacts on muscle size and glucose metabolism in mice

scientific article published on 23 January 2018

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ

scientific article

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake

scientific article

Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes

scientific article published on September 2005

Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling

scientific article published in May 2008

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

scientific article

Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat

scientific journal article

Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of rats

scientific article published on 19 August 2012

An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake

scientific article published on 01 January 2016

An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance

scientific journal article

An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake

scientific article

Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

scientific article published on 27 August 2013

Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains

scientific article published on 24 October 2017

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

scientific article

Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation

scientific article

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

scientific article published on 29 April 2019

Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance

scientific article published in March 2006

Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways ⬇️

scientific article published on August 20, 2011

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways ⬇️

scientific article published on January 1, 2002

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

scientific article published on 01 November 2018

Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle

scientific article published on 27 September 2013

Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

scientific article published on 8 September 2017

Corrigendum to "Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584].

scientific article published on 8 July 2017

Dietary protein, aging and nutritional geometry

scientific article published on 5 March 2017

Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

scientific article

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

scientific article published on 18 June 2009

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

scientific article published in December 2017

Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus

scientific article published on 11 July 2017

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids

scientific article published on 31 August 2009

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

scientific article published on 22 May 2007

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

scientific article published on 15 January 2014

Free fatty acids and skeletal muscle insulin resistance

scientific article published on June 2008

Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle

scientific article published on 5 March 2018

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression

scientific article published on 04 October 2006

Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

scientific article published on December 2006

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

scientific article

Glucose homeostasis in mice is transglutaminase 2 independent

scientific article

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

scientific article published on 04 September 2007

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation

scientific article published on November 2014

Grb10 regulates the development of fiber number in skeletal muscle

article

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

scientific article published on 13 February 2018

Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes

scientific article published on 13 October 2016

Hypothalamic regulation of energy homeostasis

scientific article

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

scientific article

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats

scientific article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats

scientific article published on 18 October 2005

Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats

scientific article published in Scientific Reports

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

scientific article published in October 2007

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

scientific article

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

scientific article

Insulin controls food intake and energy balance via NPY neurons

scientific article

Insulin signalling requires glucose to promote lipid anabolism in adipocytes

scientific article published on 28 July 2020

Lactate production is a prioritized feature of adipocyte metabolism

scientific article published on 05 November 2019

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

scientific article published on 14 April 2009

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

scientific article published on 20 November 2007

Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

scientific article published on 23 April 2018

Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice

scientific article published on 26 April 2013

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Metabolic defects induced by high-fat feeding in mice are rapidly reversed by a low-fat diet.

scientific article published in June 2012

Metabolomic analysis of insulin resistance across different mouse strains and diets.

scientific article published on 5 October 2017

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms

scientific article published in December 2004

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

scientific article

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

scientific article

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

scientific article published on 14 December 2015

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

scientific article published on 19 November 2019

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

scientific article published on 14 May 2020

Modelling insulin resistance in rodents by alterations in diet. What have "high fat" and high calorie diets revealed?

scientific article published on 7 November 2017

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction

scholarly article

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

scientific article published on November 2003

NF1 is a critical regulator of muscle development and metabolism

scientific article

Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species ⬇️

scientific article published on September 28, 2010

Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

scientific article

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

scientific article published on 21 May 2015

Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism.

scientific article

Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance

scientific article

Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo

scientific article published on 16 May 2006

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

scientific article published on 19 December 2006

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

scientific article published on 10 December 2008

Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle

scientific article

PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly

scientific article

PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis

scientific article

PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle

scientific article

Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance

scientific article published on 01 January 2002

Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo--a study using the novel PPARalpha/gamma agonist tesaglitazar

scientific article published in April 2004

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

scientific article published in June 2012

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver

scientific article

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

scientific article published on 11 October 2018

Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice

article

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling

scientific article published on 12 April 2019

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

scientific article published on 31 August 2016

Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84

scientific article published on 15 August 2019

Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

scientific journal article

Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation

scientific article

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

scientific article published on 22 April 2015

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

scientific article published on 02 April 2014

The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell

scientific article published on 01 January 2020

The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle.

scientific article published on 9 January 2015

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

scientific article published on 01 March 2020

The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice

scientific article published on 01 March 2018

The effect of α-actinin-3 deficiency on muscle aging

scientific article published on 26 November 2010

The evolution of insulin resistance in muscle of the glucose infused rat

scientific article

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice

scientific article

Thermoneutral housing does not influence fat mass or glucose homeostasis in C57BL/6 mice

scientific article published on 01 December 2018

Treatment of type 2 diabetes with the designer cytokine IC7Fc

scientific article published on 25 September 2019

Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice

scientific article published in January 2006

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

scientific article

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.

scientific article published in February 2005

α-Actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle

article

List of works by Gregory J. Cooney

A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo

AMP-activated protein kinase and muscle insulin resistance

Ablation of Grb10 specifically in muscle impacts on muscle size and glucose metabolism in mice

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake

Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes

Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat

Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of rats

An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake

An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance

An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake

Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance

Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways ⬇️

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways ⬇️

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle

Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

Corrigendum to "Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584].

Dietary protein, aging and nutritional geometry

Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

Free fatty acids and skeletal muscle insulin resistance

Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression

Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

Glucose homeostasis in mice is transglutaminase 2 independent

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation

Grb10 regulates the development of fiber number in skeletal muscle

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes

Hypothalamic regulation of energy homeostasis

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats

Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

Insulin controls food intake and energy balance via NPY neurons

Insulin signalling requires glucose to promote lipid anabolism in adipocytes

Lactate production is a prioritized feature of adipocyte metabolism

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

Metabolic defects induced by high-fat feeding in mice are rapidly reversed by a low-fat diet.

Metabolomic analysis of insulin resistance across different mouse strains and diets.

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Modelling insulin resistance in rodents by alterations in diet. What have "high fat" and high calorie diets revealed?

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

NF1 is a critical regulator of muscle development and metabolism

Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species ⬇️

Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats