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List of works by Kristin A. Eckert

A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?

scientific article

A matter of life or death: how microsatellites emerge in and vanish from the human genome

scientific article published on 12 October 2011

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

scientific article

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability ⬇️

scientific article published on October 22, 2011

Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription

scientific article

Corrigendum: A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

scientific article published on October 2016

DNA Polymerase Eta Prevents Tumor Cell Cycle Arrest And Cell Death During Recovery from Replication Stress

article

DNA polymerase kappa microsatellite synthesis: two distinct mechanisms of slippage-mediated errors

scientific article published on 11 September 2012

DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences

scientific article

DNA polymerases and human diseases

scientific article published on November 2006

DNA polymerases as chemotherapy targets: promise and challenges

scientific article published on 18 January 2019

DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis.

scientific article published on 03 June 2017

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

scientific article

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

scientific article published on 22 April 2013

Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes

scientific article

Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

scientific article published on 20 October 2018

Distinct Mutational Behaviors Differentiate Short Tandem Repeats from Microsatellites in the Human Genome ⬇️

scientific article published on January 1, 2013

Dna polymerases and their role in genomic stability ⬇️

scientific article published on October 11, 2012

Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways

scientific article

Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate

scientific article published in August 2005

Effects of oxidative and alkylating damage on microsatellite instability in nontumorigenic human cells

scientific article published in February 2004

Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles

scientific article published on 2 March 2007

Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome

scientific article published on April 2009

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

scientific article published on 27 February 2015

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition

scientific article published on 4 October 2018

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.

scientific article

Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences

scientific article published on 20 January 2009

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1.

scientific article published in June 2010

Interplay between DNA repair and inflammation, and the link to cancer

scientific article

Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate

scientific article published on 06 November 2018

Loop II of DNA polymerase beta is important for discrimination during substrate binding

scientific article published on 5 December 2008

Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis

scientific article published in May 2005

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

scientific article published on 6 January 2017

Mature Microsatellites: Mechanisms Underlying Dinucleotide Microsatellite Mutational Biases in Human Cells ⬇️

scientific article published on March 1, 2013

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication ⬇️

scientific article published on November 19, 2012

Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone

scientific article published on 28 April 2009

Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes

scientific article (publication date: July 2014)

Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay

scientific article published in August 2002

Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells

scientific article published on July 2002

Positive correlation between DNA polymerase alpha-primase pausing and mutagenesis within polypyrimidine/polypurine microsatellite sequences

scientific article published in January 2004

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

scientific article published on 01 December 2005

Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats

scientific article published on 12 July 2016

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

scientific article published on 01 April 2019

Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability

scientific article

The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation ⬇️

scientific article published on February 15, 2012

The in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesis

scientific article

The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis

scientific article

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

scientific article

Tumor-specific microsatellite instability: Do distinct mechanisms underlie the MSI-L and EMAST phenotypes? ⬇️

scientific article published on March 1, 2013

What Is a Microsatellite: A Computational and Experimental Definition Based upon Repeat Mutational Behavior at A/T and GT/AC Repeats ⬇️

scientific article published on July 28, 2010

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