List of works - Denise M. McKinney

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

scientific article

A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults

scientific article published on 26 September 2009

A population response analysis approach to assign class II HLA-epitope restrictions

scientific article

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

scientific article published on 8 February 2013

Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site

scientific article published in July 2007

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

scientific article published on June 2017

Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes

scientific article

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya

scientific article

Characterization of an in situ IFN-gamma ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization

scientific article published on 01 April 2000

Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes

scientific article published on 7 April 2015

Development and validation of a sample sparing strategy for HLA typing utilizing next generation sequencing

scientific article published on 28 May 2015

Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1 ⬇️

scientific article published on November 15, 2003

Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

scientific article

Epitope identification and vaccine design for cancer immunotherapy

scientific article

Identification of five different Patr class I molecules that bind HLA supertype peptides and definition of their peptide binding motifs

scientific article

Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection

scientific article published in October 2005

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset

scientific article

Molecular determinants of T cell epitope recognition to the common Timothy grass allergen

scientific article published on 16 June 2010

Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

scientific article published on 01 September 2001

Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

scientific article

Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya

scientific article published on 7 December 2005

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals

scientific article published on 11 February 2013

Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections

scientific article

Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL

scientific article published on 01 August 2004

Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children

scientific article

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults

scientific article published on 18 June 2014

T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts

scientific article

T-cell epitope conservation across allergen species is a major determinant of immunogenicity

scientific article published on 13 February 2016

T-lymphocyte epitope identification and their use in vaccine development for HIV-1.

scientific article

The development of multi-epitope vaccines: epitope identification, vaccine design and clinical evaluation

scientific article

The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

scientific article (publication date: December 2001)

Towards prediction of degenerate CTL epitope recognition

scientific article published on 26 October 2007

List of works by Denise M. McKinney

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults

A population response analysis approach to assign class II HLA-epitope restrictions

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya

Characterization of an in situ IFN-gamma ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization

Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes

Development and validation of a sample sparing strategy for HLA typing utilizing next generation sequencing

Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1 ⬇️

Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

Epitope identification and vaccine design for cancer immunotherapy

Identification of five different Patr class I molecules that bind HLA supertype peptides and definition of their peptide binding motifs

Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset

Molecular determinants of T cell epitope recognition to the common Timothy grass allergen

Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals

Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections

Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL

Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults

T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts

T-cell epitope conservation across allergen species is a major determinant of immunogenicity

T-lymphocyte epitope identification and their use in vaccine development for HIV-1.

The development of multi-epitope vaccines: epitope identification, vaccine design and clinical evaluation

The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

Towards prediction of degenerate CTL epitope recognition