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List of works by Akinori Akaike

A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

scientific journal article

A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia

scientific journal article

AMPA reduces surface expression of NR1 through regulation of GSK3beta

scientific article published in January 2009

Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2.

scientific article published on 18 February 2010

Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade

scientific article

Adenosine 5'-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached

scientific article published in March 2002

Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons

scientific article published in November 2004

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons

scientific article published on April 2006

Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor

scientific article published on 19 October 2006

Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

scientific article

Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro

scientific article (publication date: 29 November 2002)

Basic fibroblast growth factor promotes the generation of microtubule-associated protein 2-positive cells from microglia

scientific article published on 23 October 2009

Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells

scientific article published on 20 September 2008

Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells

scientific article published on 10 June 2008

Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity

scientific article published on 9 October 2015

Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures.

scientific article published on 18 July 2007

Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo

scientific article published on 28 August 2006

DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats

scientific article published on 19 September 2007

Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice

scientific article

Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture

scientific article

Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype

scientific article

Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice

scientific article published in September 2008

Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons

scientific article published on 15 August 2019

Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells

scientific article published on 04 August 2007

Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone

scientific article

Effects of 2'-3'-dihydroxy-4',6'-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice

scientific article published on 28 August 2019

Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices

scientific article published in August 2005

Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection

scientific article published in July 2010

Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.

scientific article published on 7 July 2004

Endogenous dopamine is involved in the herbicide paraquat-induced dopaminergic cell death

scientific article published on 17 April 2014

Endogenous factors regulating neuronal death induced by radical stress

scientific article

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

scientific article published in August 2008

Excitotoxic degeneration of hypothalamic orexin neurons in slice culture

scientific article published in February 2004

Excitotoxic injury induces production of monocyte chemoattractant protein-1 in rat cortico-striatal slice cultures

scientific article

Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx

scientific article published in August 2009

Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

scientific article

Functional and molecular interactions between Rac1 and FE65 ⬇️

scientific article published on October 5, 2011

Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo ⬇️

scientific article published on April 28, 2012

Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons

scientific article

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate ⬇️

scientific article published on February 24, 2011

Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization

scientific article published on 17 August 2012

HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats ⬇️

scientific article published on July 6, 2011

Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture

scientific article published on 31 May 2010

Hyperbilirubinemia protects against focal ischemia in rats

scientific article published in February 2003

Identification and Characterization of Novel Human Cav2.2 (α1B) Calcium Channel Variants Lacking the Synaptic Protein Interaction Site ⬇️

scientific article published on January 1, 2002

Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease

scientific article

Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells

scientific article published on 7 September 2006

In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice ⬇️

scientific article published on September 26, 2012

Increased CCL6 expression in astrocytes and neuronal protection from neuron-astrocyte interactions

scientific article published on 21 September 2019

Inhalation administration of valerena-4,7(11)-diene from Nardostachys chinensis roots ameliorates restraint stress-induced changes in murine behavior and stress-related factors.

scientific article

Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons

scientific article published in August 2003

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

scientific article

Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation

scientific article published on 05 September 2018

Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons

scientific article published on 08 February 2017

Integrin-associated protein promotes neuronal differentiation of neural stem/progenitor cells

scientific article published on 23 February 2015

Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide ⬇️

scientific article published on October 6, 2011

Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury

scientific article

Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum

scientific article

Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin

scientific article published in September 2003

Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures

scientific article

Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil

scientific article published in December 2008

Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment

scientific article published on 12 June 2008

Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation

scientific article published on 3 August 2006

Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons

scientific article published on 20 February 2010

Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection

scientific article

Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures

scientific article published in October 2004

Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons

scientific article

Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection

scientific article published in June 2003

Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture

scientific article published in August 2010

Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity

scientific article

Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases

scientific article published on 01 February 2008

N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures

scientific article published in May 2003

Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells ⬇️

scientific article published on April 27, 2011

Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons

scientific article published on 14 November 2017

Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures

scientific article published in March 2003

Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture

scientific article published on 01 January 2013

Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity

scientific article published on 23 August 2006

Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists

scientific article published in July 2003

Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons

scientific article published on 6 May 2003

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

scientific article

Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.

scientific article published on 6 March 2006

Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture

scientific article published on 21 April 2006

Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity.

scientific article published on 27 June 2009

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8.

scientific article published on 8 June 2017

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

scientific article published on 10 February 2010

Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum

scientific article published on December 2003

Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons

scientific article published on 4 September 2004

Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase

scientific article published on 12 October 2008

Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats

scientific article published on 17 October 2007

Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain

scientific article published on 01 May 2014

Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons

scientific article published in May 2005

Protective Effect of 2',3'-Dihydroxy-4',6'-dimethoxychalcone on Glutamate-Induced Neurotoxicity in Primary Cortical Cultures

scientific article published on 01 January 2020

Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in Mice

scientific article published in January 2016

Protective Effect of Green Perilla-Derived Chalcone Derivative DDC on Amyloid β Protein-Induced Neurotoxicity in Primary Cortical Neurons

scientific article published on 29 August 2019

Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice ⬇️

scientific article published on May 24, 2013

Protective Effects of 2',3'-Dihydroxy-4',6'-dimethoxychalcone Derived from Green Perilla Leaves against UV Radiation-Induced Cell Injury in Human Cultured Keratinocytes

scientific article published on 27 August 2019

Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model

scientific article published on 3 February 2017

Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures

scientific article published on 23 June 2010

Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats

scientific article published on 7 March 2008

Protective effect of serofendic acid, administered intravenously, on cerebral ischemia-reperfusion injury in rats ⬇️

scientific article published on August 13, 2013

Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1

scientific article published on 23 July 2020

Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage

scientific article

Quantification of axotomized ganglion cell death by explant culture of the rat retina

scientific article published in December 2002

Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation

scientific article published in August 2005

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

scientific article published on July 2009

Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures

scientific article published on 30 July 2010

Reduction of Immunoreactivity Against the C-Terminal Region of the Intracellular α-Synuclein by Exogenous α-Synuclein Aggregates: Possibility of Conformational Changes

scientific article published on 16 June 2016

Regulation of Dopaminergic Neuronal Death by Endogenous Dopamine and Proteasome Activity ⬇️

scientific article published on 01 January 2011

Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons.

scientific article

Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter

scientific article published on 28 December 2007

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

scientific article published on 9 November 2006

Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: involvement of N-methyl-D-aspartate receptor

scientific article published in August 2003

Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling.

scientific article

Role of nitric oxide in survival and death of neurons

scientific article published in January 2002

Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation

scientific article

Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats

scientific article published on 31 August 2005

Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons

scientific article published in September 2003

Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes

scientific article published on 2 January 2009

Serofendic acid promotes survival of auditory hair cells and neurons of mice

scientific article published in May 2005

Serofendic acid protects against myocardial ischemia-reperfusion injury in rats

scientific article published on 01 November 2014

Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation

scientific article published on 3 May 2006

Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes

scientific article published on 17 April 2006

Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection

scientific article published on January 2007

Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons

scientific article

Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of rapamycin signaling pathway

scientific article published on 22 September 2013

Synthesis and neuroprotective effects of serofendic acid analogues

scientific article published on 10 August 2006

Synthesis and pharmacological profile of serofendic acids A and B

scientific article published on 22 August 2007

Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures

scientific article

Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: involvement of direct inhibition of caspase-3.

scientific article published in June 2008

Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures

scientific article published on 5 December 2005

Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane

scientific article published on December 2003

Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons

scientific article published on 28 November 2005

Vitamin B6 protects primate retinal neurons from ischemic injury

scientific article published in June 2002

Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation.

scientific article

[Endogenous factors regulating neuronal apoptosis].

scientific article

[Factors regulating regeneration and differentiation of the retina]

scientific article published on 01 April 2010

alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta

scientific article published in April 2008

c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production

scientific article published in January 2006

p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.

scientific article published on March 2005

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