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List of works by Mark R. Hellmich

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

scientific article published on 04 March 2019

3302 Student Leadership Training effects on team dynamics and collaborative work in high-pressure, interprofessional team environments

A functional in vitro model to examine signaling mechanisms in gastrin-mediated human cell growth

scientific article published on January 1997

Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells

scientific article published on 5 April 2001

Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1

scientific article published on 01 October 2000

Agonist- and Protein Kinase C-Induced Phosphorylation Have Similar Functional Consequences for Gastrin-Releasing Peptide Receptor Signaling via Gq ⬇️

scientific article published on October 1, 2003

Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant

scientific article published on 29 July 2004

Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion

scientific article (publication date: March 2004)

Apigenin Decreases Acinar Cell Damage in Pancreatitis

scientific article published on 01 May 2019

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

scientific article published on 19 February 2015

BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation

scientific article published on 21 February 2013

Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor

scientific article

Bombesin enhances TGF-beta growth inhibitory effect through apoptosis induction in intestinal epithelial cells

scientific article

Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells

scientific article published in July 2003

Bombesin-mediated AP-1 activation in a human gastric cancer (SIIA).

scientific article

Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis

scientific article

Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1 ⬇️

scientific article published on August 1, 1998

CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells

scientific article

CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells

scientific article published on 12 December 2011

Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C

scientific article published on 01 March 1999

Colorectal Cancer-Associated Fibroblasts are Genotypically Distinct

scientific article

Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications.

scientific article

Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth

scientific article published on 14 August 2006

Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells ⬇️

scientific article published on August 1, 1997

Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury

scientific article published in October 2002

Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.

scientific article published on 21 April 2016

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

scientific article

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells

scientific article published on 20 October 2017

Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

scientific article published on January 2014

Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

scientific article

Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation

scientific article published on 21 August 2013

Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin.

scientific article

Epidermal Growth Factor Potentiates Cholecystokinin/Gastrin Receptor-mediated Ca2+ Release by Activation of Mitogen-activated Protein Kinases ⬇️

scientific article published on November 5, 2003

Expression of gastrin-releasing peptide receptors in endometrial cancer

scientific article published in June 2003

Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor

scientific article published on 17 September 2002

Gastrin, inflammation, and carcinogenesis

scientific article published on February 2010

Gastrin-releasing peptide is a growth factor for human neuroblastomas.

scientific article

Gastrin-releasing peptide receptor in breast cancer mediates cellular migration and interleukin-8 expression

scientific article

Gastrointestinal hormone receptors in primary human colorectal carcinomas

scientific article published on 27 July 2005

Glucagon-like peptide 2 is a potent growth factor for small intestine and colon

scientific article published on 01 March 1998

Glutamine deprivation induces apoptosis in intestinal epithelial cells ⬇️

scientific article published on August 1, 1998

Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

scientific article published on 5 July 2015

Gut peptide receptor expression in human pancreatic cancers

scientific article

H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

scientific article published on 9 April 2017

Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth

scientific article

Hydrogen Sulfide and Cancer

scientific article

Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth

scientific article published on 01 October 1996

Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2

scientific article published on 01 December 1998

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.

scientific article

Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON.

scientific article published on 9 September 2004

Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692

scientific article published on 01 May 1997

Integration of leadership training for graduate and medical students engaged in translational biomedical research: Examining self-efficacy and self-insight

scientific article published on 01 February 2018

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens

scientific article published on 31 January 2016

JMV1155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo

scientific article published on 01 January 1999

Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion

scientific article published on 01 August 1999

Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy

scientific article

Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626

scientific article published on July 1, 1998

Overexpression of Evi‐1 oncoprotein represses TGF‐β signaling in colorectal cancer ⬇️

scientific article published on 07 December 2011

PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion

scientific article

PTHrP is a novel mediator for TGF-β-induced apoptosis

scientific article published on 13 March 2013

Patient-derived Xenografts from Colorectal Carcinoma: A Temporal and Hierarchical Study of Murine Stromal Cell Replacement

scientific article published in July 2017

Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo

scientific article

Phorbol ester-mediated neurotensin secretion is dependent on the PKC-alpha and -delta isoforms

scientific article published on November 2002

Prevention of mucosal atrophy: role of glutamine and caspases in apoptosis in intestinal epithelial cells

scientific article published in July 2000

Raf-1 Kinase Inhibitory Protein (RKIP) Mediates Ethanol-induced Sensitization of Secretagogue Signaling in Pancreatic Acinar Cells ⬇️

scientific article published on August 2, 2012

Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells

scientific article published on 24 July 2002

Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells ⬇️

scientific article published on July 11, 2011

Regulation of growth of human gastric cancer by gastrin and glycine- extended progastrin ⬇️

scientific article published on 01 September 1997

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

scientific article published on April 2014

Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic Tissues ⬇️

scientific article published on October 1, 2003

Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation

scientific article published on 23 October 2017

Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis ⬇️

scientific article published on January 23, 2012

SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant

scientific article published on 3 August 2005

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of

scientific article published on 10 August 2016

Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death

scientific article published on August 2002

Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA

scientific article published on 01 August 2000

Src-mediated activation of the human neurotensin/neuromedin N promoter ⬇️

scientific article published on August 1, 1997

Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta

scientific article published on 20 December 2007

Targeting of a CCK(2) receptor splice variant with (111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin

scientific article

The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators.

scientific article

The role of Src family kinases in the normal and neoplastic gastrointestinal tract.

scientific article published on October 1996

The role of caspases in methotrexate-induced gastrointestinal toxicity

scientific article

The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase.

scientific article published on 27 April 2004

The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer

scientific article

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

scientific article published on 08 July 2013

Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.

scientific article published on 18 September 2017

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