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List of works by Thomas Carell

"Post-it" type connected DNA created with a reversible covalent cross-link

scientific article

2'-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes

scientific article

5-Formyl- and 5-Carboxydeoxycytidines Do Not Cause Accumulation of Harmful Repair Intermediates in Stem Cells

scientific article

5-Formylcytosin ist vermutlich eine semipermanente Base an definierten Genompositionen

5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites

scientific article

5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo

scientific article published on 27 November 2017

5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases

scientific article

5-Hydroxymethylcytosine, the sixth base of the genome

scientific article published on 17 June 2011

8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1.

scientific article published on 25 March 2011

A Click-Chemistry-Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

scientific article published on 28 November 2019

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue

scientific article published on 17 January 2019

A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction

scientific article published on 21 March 2012

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

scholarly article by Axel Schlossbauer et al published 10 June 2010 in Angewandte Chemie International Edition

A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry

scientific article

A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway

scientific article published in May 2016

A highly DNA-duplex-stabilizing metal-salen base pair

scientific article published in November 2005

A new ground state single electron donor for excess electron transfer studies in DNA.

scientific article

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

scientific article published on 01 February 2019

A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma

scientific article

A short and efficient synthesis of the tRNA nucleosides PreQ0 and archaeosine

scientific article published on 12 October 2007

ALKBH5-induced demethylation of mono- and dimethylated adenosine

scientific article published on 16 July 2018

Active DNA demethylation at enhancers during the vertebrate phylotypic period

scientific article published on 29 February 2016

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues

scientific article

Analysis of an Active Deformylation Mechanism of 5-Formyl-deoxycytidine (fdC) in Stem Cells

scientific article published on 25 February 2020

Antiferromagnetic coupling of stacked Cu(II)-salen complexes in DNA.

scientific article published in July 2010

Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U. ⬇️

scientific article published on 8 February 2011

Author Correction: Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals

scientific article published on 17 December 2020

Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode

scientific article

Base pairing and replicative processing of the formamidopyrimidine-dG DNA lesion

scientific article published in December 2005

Bioorthogonal Chemistry-Introduction and Overview.

scientific article published on February 2016

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta

scientific article

CPD damage recognition by transcribing RNA polymerase II

scientific article published on 9 February 2007

Catalysis and regulation

Cell-penetrating and neurotargeting dendritic siRNA nanostructures.

scientific article published on 17 December 2014

Chain-like assembly of gold nanoparticles on artificial DNA templates via ‘click chemistry’

Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine

scientific article published on 24 November 2015

Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates

scientific article

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation

scientific article published on 01 July 2014

Charge separation and charge delocalization identified in long-living states of photoexcited DNA.

scientific article published on 10 March 2014

Chemical discrimination between dC and 5MedC via their hydroxylamine adducts

scientific article

Chemical investigation of light induced DNA bipyrimidine damage and repair

scientific article

Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA

scientific article published on 14 January 2020

Cleavable substrate containing molecular beacons for the quantification of DNA-photolyase activity.

scientific article published in November 2002

Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing

scientific article published in 2022

Click Chemistry as a Reliable Method for the High-Density Postsynthetic Functionalization of Alkyne-Modified DNA

scientific article published in 2006

Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells

scientific article

Click–Click–Click: Single to Triple Modification of DNA

scholarly article by Philipp M. E. Gramlich et al published 21 April 2008 in Angewandte Chemie International Edition

Cockayne syndrome: varied requirement of transcription-coupled nucleotide excision repair for the removal of three structurally different adducts from transcribed DNA

scientific article (publication date: 2014)

Complex Sequence Dependence by Excess-Electron Transfer through DNA with Different Strength Electron Acceptors

article

Controlled Stacking of 10 Transition-Metal Ions inside a DNA Duplex

scientific article published on 01 January 2007

Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition

scientific article

Crystal structure analysis of DNA lesion repair and tolerance mechanisms

scientific article published on 04 February 2009

Crystal structure and mechanism of a DNA (6-4) photolyase

scientific article

Crystal structure of a cisplatin-(1,3-GTG) cross-link within DNA polymerase eta

scientific article

Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair

scientific article

Crystal structure of the T(6-4)C lesion in complex with a (6-4) DNA photolyase and repair of UV-induced (6-4) and Dewar photolesions

scientific article

Crystal structures and repair studies reveal the identity and the base-pairing properties of the UV-induced spore photoproduct DNA lesion

scientific article

Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA

scientific article

Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts

scientific article

DNA (6-4) photolyases reduce Dewar isomers for isomerization into (6-4) lesions

scientific article

DNA Repair

scholarly article by Thomas Carell published 19 November 2015 in Angewandte Chemie International Edition

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

scientific article published on 9 September 2011

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy.

scientific article published on 04 August 2016

DNA methylation and differential gene regulation in photoreceptor cell death

scientific article published on 4 December 2014

DNA photography: an ultrasensitive DNA-detection method based on photographic techniques.

scientific article published in January 2007

DNA--metal base pairs

scientific article published on January 2007

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

scientific article

Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine

scientific article published on 17 September 2013

Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ

scientific article published on 22 June 2017

Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases

Direct observation of a deoxyadenosyl radical in an active enzyme environment.

scientific article published on 23 November 2016

Directed DNA metallization.

scientific article

Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway

scientific article published in 2012

Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions

scientific article published in 2011

Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG.

scientific article

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

scientific article

Effect of Opalescence® bleaching gels on the elution of dental composite components

Efficient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo-Grignard Method

Efficient synthesis of 5-hydroxymethylcytosine containing DNA.

scientific article published on 17 November 2010

Ein auf Sulfoxid basierendes, isobares Derivatisierungsreagens für die präzise quantitative Massenspektrometrie

Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase

scientific article

Excess electron transfer driven DNA repair does not depend on the transfer direction

scientific article published in March 2004

Excess electron transport through DNA: a single electron repairs more than one UV-induced lesion

scientific article published in March 2004

Excess electron-transfer-based repair of a Cis-Syn thymine dimer in DNA is not sequence dependent

scientific article published in February 2004

Fingerprinting DNA Oxidation Processes: IR Characterization of the 5-Methyl-2′-Deoxycytidine Radical Cation

Flavin-Induced DNA Photooxidation and Charge Movement Probed by Ultrafast Transient Absorption Spectroscopy

scientific article published in 2011

Fluorescent DNA nanotags featuring covalently attached intercalating dyes: synthesis, antibody conjugation, and intracellular imaging

scientific article

Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions

scientific article published on 25 October 2013

Formation of Bimetallic Ag–Au Nanowires by Metallization of Artificial DNA Duplexes

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release.

scientific article published on 29 March 2016

German reforms would make little difference

scientific article published in Nature

High-density DNA functionalization by a combination of Cu-catalyzed and cu-free click chemistry

scientific article published in June 2010

Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange

scientific article published on 11 July 2020

Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine

scientific article from 2011

Independent generation of C5'-nucleosidyl radicals in thymidine and 2'-deoxyguanosine

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5-Aza-2'-deoxycytidine

scientific article published on 25 July 2019

Investigation of excess-electron transfer in DNA double-duplex systems allows estimation of absolute excess-electron transfer and CPD cleavage rates

scientific article published on 16 November 2010

Investigation of the Pathways of Excess Electron Transfer in DNA with Flavin-Donor and Oxetane-Acceptor Modified DNA Hairpins

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency

scientific article published on 4 October 2012

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides

scientific article published on 01 January 2019

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

article

Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines

scientific article published in 2016

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors

scientific article published on 2 March 2012

M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry

scientific article published on 16 March 2016

Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing

article published in 2012

Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

scientific article

Mechanism of UV-Induced Formation of Dewar Lesions in DNA

scientific article published on 23 November 2011

Mechanism of acetylaminofluorene-dG induced frameshifting by polymerase η.

scientific article

Mechanism of replication blocking and bypass of Y-family polymerase   by bulky acetylaminofluorene DNA adducts

scientific article

Mechanism of transcriptional stalling at cisplatin-damaged DNA

scientific article

Metal–Salen-Base-Pair Complexes Inside DNA: Complexation Overrides Sequence Information

scientific article published on 01 November 2006

Model compounds for (6-4) photolyases: a comparative flavin induced cleavage study of oxetanes and thietanes

scientific article published on 18 April 2005

Molecular computing: DNA as a logic operator

scientific article published in January 2011

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.

scientific article published on 4 September 2017

Natural and non-natural antenna chromophores in the DNA photolyase from Thermus thermophilus.

scientific article published in November 2006

Nicht-kanonische RNA-Nukleoside als molekulare Fossilien einer frühen Erde - Generierung durch präbiotische Methylierungen und Carbamoylierungen

Nichtkanonische Basen im Genom: die regulative Informationsebene in der DNA

Non-canonical bases in the genome: The regulatory information layer in DNA.

scientific article

Non-canonical nucleosides and chemistry of the emergence of life

scientific article published in Nature Communications

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations.

scientific article

Norbornenes in inverse electron-demand Diels-Alder reactions.

scientific article

ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization

scientific article published in May 2012

Once overlooked, now made visible: ATL proteins and DNA repair.

scientific article

Orchestrating the biosynthesis of an unnatural pyrrolysine amino Acid for its direct incorporation into proteins inside living cells.

scientific article

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

scientific article

PNA-based reagents for the direct and site-specific synthesis of thymine dimer lesions in genomic DNA.

scientific article published in February 2006

Parallel isotope-based quantification of modified tRNA nucleosides.

scientific article

Phosphorothioation of oligonucleotides strongly influences the inhibition of bacterial (M.HhaI) and human (Dnmt1) DNA methyltransferases

scientific article published in March 2009

Postsynthetic DNA modification through the copper-catalyzed azide-alkyne cycloaddition reaction

scientific article published on January 2008

Programmable self-assembly of metal ions inside artificial DNA duplexes

scientific article published on 26 November 2006

Proto-Urea-RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

scientific article published on 30 October 2019

Publisher Correction: Non-canonical nucleosides and chemistry of the emergence of life

scientific article published in Nature Communications

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

scientific article published in July 2010

Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues

scientific article

RNA is more UV resistant than DNA: the formation of UV-induced DNA lesions is strongly sequence and conformation dependent.

scientific article published in November 2004

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals

scientific article published on 24 November 2020

Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome

scientific article

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

scientific article published on 02 July 2021

Regioselective Metalations of Pyrimidines and Pyrazines by Using Frustrated Lewis Pairs of BF3⋅OEt2and Hindered Magnesium- and Zinc-Amide Bases

scholarly article by Klaus Groll et al published 23 May 2013 in Angewandte Chemie International Edition

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA

scientific article

Release and protein binding of components from resin based composites in native saliva and other extraction media

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

scientific article

Rethinking the tools of the RNA world.

scientific article published on 15 June 2018

Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair

scientific article

Ribose-protonated DNA base excision repair: a combined theoretical and experimental study

scientific article

Ring opening of the cyclobutane in a thymine dimer radical anion

Robust Synthesis and Crystal-Structure Analysis of 7-Cyano-7-deazaguanine (PreQ0 Base) and 7-(Aminomethyl)-7-deazaguanine (PreQ1 Base)

article

Selective detection of 5-methylcytosine sites in DNA.

scientific article published in January 2008

Self-Repairing DNA Based on a Reductive Electron Transfer through the Base Stack

scientific article published on 01 November 2000

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

scientific article published on 13 March 2020

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex

scientific article published on 8 September 2016

Strand-specific recognition of DNA damages by XPD provides insights into nucleotide excision repair substrate versatility

scientific article published on 14 December 2013

Structural Insights into the Recognition of N2 -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14.

scientific article published on 26 April 2017

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase

scientific article

Structural biology of DNA photolyases and cryptochromes

scientific article published on 30 May 2009

Structural insights into incorporation of norbornene amino acids for click modification of proteins

scientific article

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme

scientific article

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

scientific article published on 22 June 2015

Structure and function of noncanonical nucleobases

scientific article published on 28 June 2012

Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs

scientific article published in 2022

Surface "click" reaction of DNA followed by directed metalization for the construction of contactable conducting nanostructures

scientific article published on 15 June 2012

Switching the mechanics of dsDNA by Cu salicylic aldehyde complexation

scientific article published on 2 October 2009

Synthesis and properties of DNA containing a spore photoproduct analog

Synthesis and properties of a Cu(ii) complexing pyrazole ligandoside in DNA

scientific article published on 01 January 2014

Synthesis and stereochemical assignment of DNA spore photoproduct analogues

scientific article published on August 2006

Synthesis of (R)-Configured 2'-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides

scientific article published on 19 August 2016

Synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxycytidine-triphosphates and their incorporation into oligonucleotides by polymerase chain reaction.

scientific article

Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1.

scientific article published on January 2008

Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry

article published in 2007

Synthesis of Modified DNA by PCR with Alkyne-Bearing Purines Followed by a Click Reaction

scientific article published in 2008

Synthesis of RNA Containing 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine.

scientific article

Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids

scientific article published on 01 December 2009

Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine.

scientific article published on 26 November 2013

Synthesis of a stabilized version of the imidazolone DNA lesion

scientific article

Synthesis of an acp3U phosphoramidite and incorporation of the hypermodified base into RNA

scientific article published on 01 October 2019

Synthesis of the Transfer-RNA Nucleoside Queuosine by Using a Chiral Allyl Azide Intermediate

scholarly article by Florian Klepper et al published 19 March 2007 in Angewandte Chemie International Edition

Synthesis of γ-labeled nucleoside 5′-triphosphates using click chemistry

scientific article published on 09 January 2014

Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system

scientific article published on 28 November 2012

Systems-Based Analysis of Modified tRNA Bases

article

TET1 drives global DNA demethylation via DPPA3-mediated inhibition of maintenance methylation

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

article

Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain

scientific article published on 13 February 2014

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

scientific article published on 18 May 2014

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA

scientific article published on 15 March 2012

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

scientific article

The archaeal cofactor F 0 is a light-harvesting antenna chromophore in eukaryotes

scientific article

The chemistries and consequences of DNA and RNA methylation and demethylation

scientific article published on 25 April 2017

The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution

scientific article published on 01 January 2007

The discovery of 5-formylcytosine in embryonic stem cell DNA.

scientific article

The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair

scientific article published on 01 January 2013

The two main DNA lesions 8-Oxo-7,8-dihydroguanine and 2,6-diamino-5-formamido-4-hydroxypyrimidine exhibit strongly different pairing properties

scientific article published in October 2003

Thymine dimerization in DNA is an ultrafast photoreaction

scientific article

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

scientific article published in 2010

Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine

Total synthesis of the hypermodified RNA bases wybutosine and hydroxywybutosine and their quantification together with other modified RNA bases in plant materials

scientific article

Transfer Printing of DNA by “Click” Chemistry

article published in 2007

Translesion Synthesis of 1,3-GTG Cisplatin DNA Lesions

scholarly article by Sabine Schneider published in June 2010

Triplet-Induced Lesion Formation at CpT and TpC Sites in DNA

scientific article published on 25 October 2019

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

scientific article published on 17 August 2016

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

scientific article

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

scientific article published in 2015

Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions

scientific article

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

scientific article

Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA

scholarly article by Dominik B. Bucher et al published 4 September 2014 in Angewandte Chemie International Edition

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

scientific article published on 11 January 2018

Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization

scientific article published on 20 August 2014

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