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List of works by John J. Stegeman

2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis

scientific article published on 01 September 2002

A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection

scientific article published on 28 April 2006

Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish ⬇️

scientific article published on October 2, 2012

Altered gene expression associated with epizootic shell disease in the American lobster, Homarus americanus

scientific article published on 20 August 2010

Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish

scientific article published on 25 July 2003

Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish

scientific article published on 12 March 2007

Basal and 3-methylcholanthrene-induced expression of cytochrome P450 1A, 1B and 1C genes in the Brazilian guppy, Poecilia vivipara ⬇️

scientific article published on August 14, 2012

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner

scientific article published on 22 April 2016

Biomarkers of PAH exposure in an intertidal fish species from Prince William Sound, Alaska: 2004-2005

scientific article published on 01 October 2006

CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae

scientific article published on 01 March 2020

Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus)

scientific article

Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase.

scientific article published in January 2005

Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).

scientific article

Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions

scientific article published on 21 February 2015

Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

scientific article published on 08 October 2020

Cytochrome P450 1 Genes in Birds: Evolutionary Relationships and Transcription Profiles in Chicken and Japanese Quail Embryos ⬇️

scientific article published on December 2, 2011

Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family

scientific article published on 4 October 2007

Cytochrome P450 1A Induction in Sea Ducks Inhabiting Nearshore Areas of Prince William Sound, Alaska

scholarly article by Kimberly A. Trust et al published May 2000 in Marine Pollution Bulletin

Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds

scientific article published on 5 May 2006

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders

scientific article (publication date: April 2016)

Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression

scientific article

Cytochrome P4501A induction and inhibition by 3,3′,4,4′-tetrachlorobiphenyl in an Ah receptor-containing fish hepatoma cell line (PLHC-1)

scholarly article by Mark E. Hahn et al published August 1993 in Aquatic Toxicology

Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus

scientific article published on 14 November 2005

Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States

scientific article

Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata

scientific article published in January 2005

Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio

scientific article

Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on 03 June 2009

EZR1: a novel family of highly expressed retroelements induced by TCDD and regulated by a NF-κB-like factor in embryos of zebrafish (Danio rerio).

scientific article

Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties

scientific article published on 22 June 2011

Editor’s Note

Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologs

scientific article published on 15 February 2007

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

scientific article

Evaluating cytochrome p450 in lesser scaup (Aythya affinis) and tree swallow (Tachycineta bicolor) by monooxygenase activity and immunohistochemistry: possible nonlethal assessment by skin immunohistochemistry

scientific article published in October 2006

Exposure to hydrocarbons 10 years after the Exxon Valdez oil spill: evidence from cytochrome P4501A expression and biliary FACs in nearshore demersal fishes

scientific article published on 01 January 2002

Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.

scientific article

Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants

scientific article published in October 2002

Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics

scientific article

Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)

scientific article published on 20 September 2013

Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast

scientific article

Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics

scientific article

Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes).

scientific article published on 26 February 2008

Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution

scientific article

Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo

scientific article published on 13 June 2013

Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish

scientific article

Human Health and Ocean Pollution

scientific article published on 03 December 2020

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

scientific article

Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis

scientific article

Identification of CYP genes in Mytilus (mussel) and Crassostrea (oyster) species: first approach to the full complement of cytochrome P450 genes in bivalves

scientific article

Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase

scientific article

Independent losses of a xenobiotic receptor across teleost evolution

Induction of cetacean cytochrome P4501A1 by beta-naphthoflavone exposure of skin biopsy slices

scientific article published on 31 March 2004

Induction of cytochrome P-450E (P-450IA1) by 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF) in the marine fish scup (Stenotomus chrysops)

Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation

scientific article

Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish

scientific article published in May 2003

Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish

scientific article

Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp.): A CYP3 line in early deuterostomes?

article

Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish

scientific article published on 7 May 2010

Methodological approaches to cytochrome P450 profiling in embryos

scientific article published on January 2012

Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus

scientific article published on 7 July 2017

Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions

scientific article published on 26 July 2005

New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development

scientific article

New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126

scientific article published on 15 May 2009

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)

scientific article

On the occurrence of cytochrome P450 in viruses

scientific article

Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.

scientific article

Phylogenetic distribution of the Ah receptor in non-mammalian species: implications for dioxin toxicity and Ah receptor evolution

scholarly article by Mark E. Hahn & John J. Stegeman published October 1992 in Chemosphere

Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities

scientific article published on 15 July 2016

Precision-cut liver slices to investigate responsiveness of deep-sea fish to contaminants at high pressure

article published in 2012

RAPID ASSESSMENT OF INDUCED CYTOCHROME P4501A PROTEIN AND CATALYTIC ACTIVITY IN FISH HEPATOMA CELLS GROWN IN MULTIWELL PLATES: RESPONSE TO TCDD, TCDF, AND TWO PLANAR PCBS

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor

scientific article

Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells

scientific article

Retinal neuronal cell is a toxicological target of tributyltin in developing zebrafish

scientific article published on 01 June 2006

Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish

scientific article

Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2 ⬇️

scientific article published on April 12, 2011

Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison

scientific article

Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function

scientific article published on 01 March 2019

Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells

scientific article published on April 2002

Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops).

scientific article published in April 2002

Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp.

scientific article published on 5 August 2011

The African coelacanth genome provides insights into tetrapod evolution

scientific article

The Ah receptor in marine animals: phylogenetic distribution and relationship to cytochrome P4501A inducibility

scholarly article by Mark E. Hahn et al published January 1992 in Marine Environmental Research

The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers

scientific article published on 29 May 2013

The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s

scientific article (publication date: 19 February 2013)

The genome of the sea urchin Strongylocentrotus purpuratus

scientific article

The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families

scientific article

The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis.

scientific article

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo

scientific article

The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish

scientific article

Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure

scientific article published in August 2002

Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners

scientific article published on 28 February 2006

Uptake of waterborne 3,3′,4,4′-tetrachlorobiphenyl and organ and cell-specific induction of cytochrome P4501A in adult and larval fathead minnow Pimephales promelas

cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos

scientific article published on September 2002

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