Search filters

List of works by Olivier Michielin

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

scientific article published on 16 July 2016

A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide

scientific article

A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.

scientific article

A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable? ⬇️

scientific article published on February 4, 2013

A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity.

scientific article published on December 2006

A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1 immunodominant nonapeptide but not the corresponding decapeptide

scientific article published on December 2007

Access of extracellular cations to their binding sites in Na,K-ATPase: role of the second extracellular loop of the alpha subunit

scientific article

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

scientific article published on September 2014

Attracting cavities for docking. Replacing the rough energy landscape of the protein by a smooth attracting landscape

scientific article published on 12 November 2015

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

scientific article

Blind docking of 260 protein-ligand complexes with EADock 2.0.

scientific article published in October 2009

CD3 delta establishes a functional link between the T cell receptor and CD8

scientific article (publication date: 31 January 2003)

CD73 expression and clinical significance in human metastatic melanoma.

scientific article published in June 2018

CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers

scientific article

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

scientific article published on 13 May 2015

Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptorα Helix 12 Dynamic Behavior

scientific article published in Journal of Biological Chemistry

Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors

scientific article published on 25 February 2017

Comparison between computational alanine scanning and per-residue binding free energy decomposition for protein-protein association using MM-GBSA: application to the TCR-p-MHC complex

scientific article published in June 2007

Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.

scientific article published on 26 February 2016

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses

scientific article

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

scientific article

Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues

scholarly article

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding

scientific article published on 18 January 2020

Docking to heme proteins.

scientific article published in November 2009

Docking, virtual high throughput screening and in silico fragment-based drug design

scientific article published on 21 January 2009

Dramatic response of vemurafenib-induced cutaneous lesions upon switch to dual BRAF/MEK inhibition in a metastatic melanoma patient.

scientific article published in October 2014

Drug Design Workshop: A Web-Based Educational Tool To Introduce Computer-Aided Drug Design to the General Public

article by Antoine Daina et al published 27 February 2017 in Journal of Chemical Education

EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.

scientific article published in June 2007

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

scientific article

Expanding molecular modeling and design tools to non-natural sidechains

scientific article published on 14 April 2012

Fast docking using the CHARMM force field with EADock DSS.

scientific article published on 3 May 2011

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

scientific article

Fourier transform convolution integrals applied to generalized Born molecular volume

scientific article published on February 2010

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab

scientific article published on 20 December 2013

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition.

scientific article published on 23 September 2009

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

scientific article

Guillain-Barré syndrome after adoptive cell therapy with tumor-infiltrating lymphocytes

scientific article published on 01 August 2020

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

scientific article

How T cell receptors interact with peptide‐MHCs: A multiple steered molecular dynamics study ⬇️

scientific article published on August 30, 2011

Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity

scientific article published on 22 September 2011

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays

scientific article

Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression

scientific article

Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients

scientific article published on 20 April 2007

Impact of orthologous melan-A peptide immunizations on the anti-self melan-A/HLA-A2 T cell cross-reactivity

scientific article published on June 2006

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

scientific article

In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1.

scientific article

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI.

scientific article

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness ⬇️

scientific article published on June 29, 2012

Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives

scientific article published on 27 July 2020

Local alignment refinement using structural assessment

scientific article

Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib

scientific article

MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial

scientific article

MedCo: Enabling Secure and Privacy-Preserving Exploration of Distributed Clinical and Genomic Data

scientific article published on 13 July 2018

Multiple nivolumab-induced CNS demyelination with spontaneous resolution in an asymptomatic metastatic melanoma patient

scientific article published on 02 December 2019

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

scientific article published on 18 September 2017

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

scientific article published on 28 August 2012

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

scientific article published on 18 January 2007

Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients

scientific article

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

scientific article published in April 2018

Phase I, open-label study of pasireotide in patients with BRAF-wild type and NRAS-wild type, unresectable and/or metastatic melanoma

scientific article published on 23 July 2018

Prediction of cross-recognition of peptide-HLA A2 by Melan-A-specific cytotoxic T lymphocytes using three-dimensional quantitative structure-activity relationships

scientific article

Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07 ⬇️

scientific article published on May 18, 2012

Principles of adoptive cell therapy based on "Tumor Infiltrating Lymphocytes"

scientific article published in May 2016

Pulmonary sarcoid-like granulomatosis induced by ipilimumab.

scientific article published on 30 April 2012

Quantification of the next-generation oral anti-tumor drugs dabrafenib, trametinib, vemurafenib, cobimetinib, pazopanib, regorafenib and two metabolites in human plasma by liquid chromatography-tandem mass spectrometry.

scientific article published on 8 February 2018

RNA pentaloop structures as effective targets of regulators belonging to the RsmA/CsrA protein family

scientific article

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

scientific article published on 22 May 2012

Rational design of indoleamine 2,3-dioxygenase inhibitors

scientific article

SHP-1 phosphatase activity counteracts increased T cell receptor affinity ⬇️

scientific article published on February 8, 2013

SPHN/PHRT - MedCo in Action: Empowering the Swiss Molecular Tumor Board with Privacy-Preserving and Real-Time Patient Discovery

scientific article published on 01 June 2020

Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

scientific article published on 15 March 2018

Sequence determinants of a microtubule tip localization signal (MtLS).

scientific article

Shaping the interaction landscape of bioactive molecules.

scientific article

Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes ⬇️

scientific article published on August 29, 2011

Structural and functional interaction sites between Na,K-ATPase and FXYD proteins.

scientific article published on 2 July 2004

Structural prediction of peptides bound to MHC class I.

scientific article published on 5 December 2005

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

scientific article published on 3 March 2017

SwissDock, a protein-small molecule docking web service based on EADock DSS

scientific article

SwissParam: A fast force field generation tool for small organic molecules

scientific article

SwissSidechain: a molecular and structural database of non-natural sidechains

scientific article published on 26 October 2012

SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening

scientific article

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

scientific article published on 3 May 2014

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

scientific article published on 01 July 2019

T-Cell Receptors Binding Orientation over Peptide/MHC Class I Is Driven by Long-Range Interactions ⬇️

scientific article published on December 14, 2012

TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires

scientific article

The Binding Mode of N-Hydroxyamidines to Indoleamine 2,3-Dioxygenase 1 (IDO1).

scientific article published on 21 July 2017

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

scientific article

The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate.

scientific article published on 05 March 2014

The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis

scientific article

The fourth extracellular loop of the alpha subunit of Na,K-ATPase. Functional evidence for close proximity with the second extracellular loop

scientific article published on 8 August 2008

The fourth transmembrane segment of the Na,K-ATPase alpha subunit: a systematic mutagenesis study

scientific article published on 28 April 2004

The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids

scientific article published on 26 September 2013

Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

scientific article published on 28 October 2020

Use of the FACTS solvation model for protein-ligand docking calculations. Application to EADock.

scientific article published in September 2010

Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial

scientific article published on 23 October 2015

Vaccination with long NY-ESO-1 79-108 peptide and CpG-B leads to robust activation of CD4 and CD8 T cell responses in stage III/IV melanoma patients, and a new HLA-DR7 epitope.

scientific article published on 4 November 2015

Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells.

scientific article

[Advances in Oncology 2019]

scientific article published on 01 January 2020

[Cardiotoxicity of immune checkpoint inhibitors used in cancer treatment]

scientific article published on 01 June 2020

[ENT management of head and neck cutaneous melanoma]

scientific article published on 01 October 2020

[Genomics medicine and oncology]

scientific article published on 01 May 2014

[Locally advanced and metastatic melanoma : novelties]

scientific article published on 01 May 2020

[New therapeutic weapons in stage IV melanoma]

[Oncology, what's new in 2018]

scientific article published on 01 January 2019

iLOGP: a simple, robust, and efficient description of n-octanol/water partition coefficient for drug design using the GB/SA approach

scientific article published on 25 November 2014

Paulina is supported by:

About Paulina

Help