List of works - Kazuki Mochizuki

(-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation

scientific article published on 16 June 2009

A higher rate of eating is associated with higher circulating interluekin-1β concentrations in Japanese men not being treated for metabolic diseases ⬇️

scientific article published on 06 April 2012

Accumulation of Visceral Fat Is Positively Associated with Serum ALT and γ-GTP Activities in Healthy and Preclinical Middle-Aged Japanese Men ⬇️

scientific article published on January 1, 2011

Add-on therapy with anagliptin in Japanese patients with type-2 diabetes mellitus treated with metformin and miglitol can maintain higher concentrations of biologically active GLP-1/total GIP and a lower concentration of leptin

scientific article published on 22 October 2016

Associations between markers of liver injury and cytokine markers for insulin sensitivity and inflammation in middle-aged Japanese men not being treated for metabolic diseases

scientific article published on 01 January 2011

BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene

scientific article published on 20 September 2017

BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver

scientific article published on 9 July 2016

Bromodomain-containing protein 4 regulates a cascade of lipid-accumulation-related genes at the transcriptional level in the 3T3-L1 white adipocyte-like cell line

scientific article published on 07 July 2020

Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol

scientific article published on 11 February 2010

Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone

scientific article published on 23 April 2008

Circulating interleukin-1β concentrations are independently-positively associated with γ-glutamyltransferase activity within the normal range in middle-aged apparently healthy Japanese women

scientific article published in January 2013

Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions

scientific article published on 05 August 2010

Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine ⬇️

scientific article published on April 1, 2011

Dietary supplementation with (-)-epigallocatechin-3-gallate reduces inflammatory response in adipose tissue of non-obese type 2 diabetic Goto-Kakizaki (GK) rats

scientific article

Dietary supplementation with a low dose of (-)-epigallocatechin-3-gallate reduces pro-inflammatory responses in peripheral leukocytes of non-obese type 2 diabetic GK rats

scientific article published in January 2013

Dietary supplementation with alpha-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue

scientific article published in October 2009

Dietary supplementation with epigallocatechin gallate elevates levels of circulating adiponectin in non-obese type-2 diabetic Goto-Kakizaki rats

scientific article published on 07 August 2007

Distribution and dietary induction of cellular retinol-binding protein type II along the villus-crypt axis of the rat jejunum

scientific article published on 01 April 2008

Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats

scientific article published on 31 May 2007

Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats

scientific article published on 01 February 2009

Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance

scientific article published on 21 June 2019

Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities

scientific article

Epigenomic-basis of Preemptive Medicine for Neurodevelopmental Disorders

scientific article published on June 2015

Fasting during the suckling-weaning transient period of rats induces inflammatory gene expression in the adipose tissue and peripheral leukocytes

scientific article published on 25 March 2016

Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood

scientific article published on 6 May 2015

Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex

scientific article published on 14 February 2010

Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp gene in the jejunum

scientific article published on 18 January 2011

Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum toward the ileum

scientific article published in September 2009

Gene expression of inflammatory cytokines in peripheral leukocytes in db/db mice rose with progression of diabetes

scientific article published on 7 July 2010

Gene expression profile in the liver of Rana catesbeiana tadpoles exposed to low temperature in the presence of thyroid hormone ⬇️

scientific article published on March 23, 2012

Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions

scientific article published on 24 May 2008

Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression

scientific article published on 31 December 2009

Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization

scientific article published on 07 January 2011

Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients

scientific article published on 8 May 2015

In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice

scientific article published on 24 November 2010

Induction by fructose force-feeding of histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and its expression in mice.

scientific article

Induction of HOX genes by HCV infection via impairment of histone H2A monoubiquitination

scientific article published on 16 December 2020

Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum

scientific article published on 7 April 2009

Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet

scientific article

Inhibition of postprandial hyperglycemia by either an insulin-dependent or -independent drug reduces the expression of genes related to inflammation in peripheral leukocytes of OLETF rats

scientific article published on 7 November 2013

Insulin resistance in SHR/NDmc-cp rats correlates with enlarged perivascular adipocytes and endothelial cell dysfunction in skeletal muscle

scientific article published in January 2014

Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes ⬇️

scientific article published on October 8, 2010

Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms

scientific article

Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver

scientific article published on 18 December 2015

Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch ⬇️

scientific article published on July 21, 2012

Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes.

scientific article published on April 2009

Plasma TNF-α Is Associated with Inflammation and Nutrition Status in Community-Dwelling Japanese Elderly

scientific article published on January 2015

Plasma interleukin-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged nonoverweight and overweight Japanese men.

scientific article published on 19 February 2010

Plasma sE-selectin level is positively correlated with neutrophil count and diastolic blood pressure in Japanese men.

scientific article

Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acids and vitamin A through PPARalpha in developing rats.

scientific article

Prader-Willi Syndrome: The Disease that Opened up Epigenomic-Based Preemptive Medicine

scientific article published on 11 March 2016

Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases

scientific article published on 9 December 2011

Putative PPAR target genes express highly in skeletal muscle of insulin-resistant MetS model SHR/NDmc-cp rats

scientific article published in January 2015

RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor β gene activation by thyroid hormone in Rana catesbeiana tadpole liver

scientific article published on 27 December 2011

Re-feeding rats a high-sucrose diet after 3 days of starvation enhances histone H3 acetylation in transcribed region and expression of jejunal GLUT5 gene

scientific article published on 28 May 2014

Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb

scientific article published on 20 March 2018

Relationship between epigenetic regulation, dietary habits, and the developmental origins of health and disease theory

scientific article published on 7 February 2017

Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue

scientific article published on 31 October 2013

Self-reported faster eating associated with higher ALT activity in middle-aged, apparently healthy Japanese women

scientific article published in January 2014

Self-reported faster eating is positively associated with accumulation of visceral fat in middle-aged apparently healthy Japanese men.

scientific article published on 21 November 2013

Self-reported rate of eating is associated with higher circulating ALT activity in middle-aged apparently healthy Japanese men ⬇️

scientific article published on July 3, 2012

Serum Fatty Acid Binding Protein 4 Concentrations Are Positively and Independently Associated with Blood Pressure and Abdominal Fat among Parameters in Health Check-Ups in Ordinary Middle-Aged Japanese Males.

scientific article published on January 2015

Serum ^|^gamma;-GTP Activity Is Closely Associated with Serum CRP Levels in Non-Overweight and Overweight Middle-Aged Japanese Men ⬇️

scientific article published on January 1, 2013

Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients

scientific article

The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes

scientific article published on 11 February 2009

The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats

scientific article published on 7 October 2009

The alpha-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1beta and tumour necrosis factor-alpha gene expression in rat peripheral leucocytes induced by intermittent sucrose loading

scientific article published on 13 January 2009

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

scientific article published on 27 January 2008

The possible roles of homeobox protein, Cdx-2 for the expression of LPH gene during postnatal development

scientific article published on 10 November 2006

The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/low-fat diet in mice.

scientific article published in October 2010

The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus ⬇️

scientific article published on July 29, 2010

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression

scientific article published on June 2016

Treatment with DPP-4I Anagliptin or α-GI Miglitol Reduces IGT Development and the Expression of CVD Risk Factors in OLETF Rats

scientific article published in January 2015

Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes ⬇️

scientific article published on 06 May 2011

Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period.

scientific article

Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum

scientific article published on 14 February 2012

Variation in gene expression of inflammatory cytokines in leukocyte-derived cells of high-fat-diet-induced insulin-resistant rats

scientific article published on 7 October 2008

β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α.

scientific article published on 25 January 2010

List of works by Kazuki Mochizuki

(-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation

A higher rate of eating is associated with higher circulating interluekin-1β concentrations in Japanese men not being treated for metabolic diseases ⬇️

Accumulation of Visceral Fat Is Positively Associated with Serum ALT and γ-GTP Activities in Healthy and Preclinical Middle-Aged Japanese Men ⬇️

Add-on therapy with anagliptin in Japanese patients with type-2 diabetes mellitus treated with metformin and miglitol can maintain higher concentrations of biologically active GLP-1/total GIP and a lower concentration of leptin

Associations between markers of liver injury and cytokine markers for insulin sensitivity and inflammation in middle-aged Japanese men not being treated for metabolic diseases

BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene

BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver

Bromodomain-containing protein 4 regulates a cascade of lipid-accumulation-related genes at the transcriptional level in the 3T3-L1 white adipocyte-like cell line

Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol

Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone

Circulating interleukin-1β concentrations are independently-positively associated with γ-glutamyltransferase activity within the normal range in middle-aged apparently healthy Japanese women

Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions

Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine ⬇️

Dietary supplementation with (-)-epigallocatechin-3-gallate reduces inflammatory response in adipose tissue of non-obese type 2 diabetic Goto-Kakizaki (GK) rats

Dietary supplementation with a low dose of (-)-epigallocatechin-3-gallate reduces pro-inflammatory responses in peripheral leukocytes of non-obese type 2 diabetic GK rats

Dietary supplementation with alpha-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue

Dietary supplementation with epigallocatechin gallate elevates levels of circulating adiponectin in non-obese type-2 diabetic Goto-Kakizaki rats

Distribution and dietary induction of cellular retinol-binding protein type II along the villus-crypt axis of the rat jejunum

Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats

Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats

Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance

Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities

Epigenomic-basis of Preemptive Medicine for Neurodevelopmental Disorders

Fasting during the suckling-weaning transient period of rats induces inflammatory gene expression in the adipose tissue and peripheral leukocytes

Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood

Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex

Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp gene in the jejunum

Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum toward the ileum

Gene expression of inflammatory cytokines in peripheral leukocytes in db/db mice rose with progression of diabetes

Gene expression profile in the liver of Rana catesbeiana tadpoles exposed to low temperature in the presence of thyroid hormone ⬇️

Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions

Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression

Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization

Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients

In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice

Induction by fructose force-feeding of histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and its expression in mice.

Induction of HOX genes by HCV infection via impairment of histone H2A monoubiquitination

Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum

Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet

Inhibition of postprandial hyperglycemia by either an insulin-dependent or -independent drug reduces the expression of genes related to inflammation in peripheral leukocytes of OLETF rats

Insulin resistance in SHR/NDmc-cp rats correlates with enlarged perivascular adipocytes and endothelial cell dysfunction in skeletal muscle

Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes ⬇️

Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms

Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver

Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch ⬇️

Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes.

Plasma TNF-α Is Associated with Inflammation and Nutrition Status in Community-Dwelling Japanese Elderly

Plasma interleukin-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged nonoverweight and overweight Japanese men.

Plasma sE-selectin level is positively correlated with neutrophil count and diastolic blood pressure in Japanese men.

Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acids and vitamin A through PPARalpha in developing rats.

Prader-Willi Syndrome: The Disease that Opened up Epigenomic-Based Preemptive Medicine

Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases

Putative PPAR target genes express highly in skeletal muscle of insulin-resistant MetS model SHR/NDmc-cp rats

RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor β gene activation by thyroid hormone in Rana catesbeiana tadpole liver

Re-feeding rats a high-sucrose diet after 3 days of starvation enhances histone H3 acetylation in transcribed region and expression of jejunal GLUT5 gene

Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb

Relationship between epigenetic regulation, dietary habits, and the developmental origins of health and disease theory

Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue

Self-reported faster eating associated with higher ALT activity in middle-aged, apparently healthy Japanese women

Self-reported faster eating is positively associated with accumulation of visceral fat in middle-aged apparently healthy Japanese men.

Self-reported rate of eating is associated with higher circulating ALT activity in middle-aged apparently healthy Japanese men ⬇️

Serum Fatty Acid Binding Protein 4 Concentrations Are Positively and Independently Associated with Blood Pressure and Abdominal Fat among Parameters in Health Check-Ups in Ordinary Middle-Aged Japanese Males.

Serum ^|^gamma;-GTP Activity Is Closely Associated with Serum CRP Levels in Non-Overweight and Overweight Middle-Aged Japanese Men ⬇️

Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients

The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes

The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats

The alpha-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1beta and tumour necrosis factor-alpha gene expression in rat peripheral leucocytes induced by intermittent sucrose loading

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

The possible roles of homeobox protein, Cdx-2 for the expression of LPH gene during postnatal development

The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/low-fat diet in mice.

The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus ⬇️

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression

Treatment with DPP-4I Anagliptin or α-GI Miglitol Reduces IGT Development and the Expression of CVD Risk Factors in OLETF Rats

Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes ⬇️

Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period.

Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum

Variation in gene expression of inflammatory cytokines in leukocyte-derived cells of high-fat-diet-induced insulin-resistant rats

β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α.