List of works - Alan B. Northrup

A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis

scientific article published on 20 September 2007

Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.

scientific article

Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization

scientific article published on 7 October 2016

Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.

scientific article

Discovery of 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c-Met ⬇️

scientific article published on March 18, 2013

Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening

scientific article

Efficient identification of novel leads by dynamic focused screening: PDK1 case stud

scientific article

Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates

scientific article

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR

scientific article

Identification of direct target engagement biomarkers for kinase-targeted therapeutics

scientific article

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

scientific article published on 18 April 2017

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

scientific article published on 15 July 2016

Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.

scientific article published in December 2013

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation

scientific article published on 25 August 2016

Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.

scientific article published on 16 February 2015

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

scientific article published in April 2011

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors

scientific article published on 22 October 2016

The first direct and enantioselective cross-aldol reaction of aldehydes

scientific article

The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones

scientific article

The importance of iminium geometry control in enamine catalysis: identification of a new catalyst architecture for aldehyde-aldehyde couplings

scientific article published in December 2004

Total synthesis and structural revision of callipeltoside C.

scientific article published on January 2008

Two-step synthesis of carbohydrates by selective aldol reactions

scientific article

List of works by Alan B. Northrup

A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis

Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.

Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization

Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.

Discovery of 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c-Met ⬇️

Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening

Efficient identification of novel leads by dynamic focused screening: PDK1 case stud

Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR

Identification of direct target engagement biomarkers for kinase-targeted therapeutics

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation

Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors

The first direct and enantioselective cross-aldol reaction of aldehydes

The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones

The importance of iminium geometry control in enamine catalysis: identification of a new catalyst architecture for aldehyde-aldehyde couplings

Total synthesis and structural revision of callipeltoside C.

Two-step synthesis of carbohydrates by selective aldol reactions