List of works - Aiming Sun

3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: the persistence of axial fluorine

scientific article

A target site for template-based design of measles virus entry inhibitors.

scholarly article

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

scientific article

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

scientific article

Antiviral atropisomers: conformational energy surfaces by NMR for host-directed myxovirus blockers

scientific article

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

scientific article published on 30 January 2013

Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog

scientific article

Cancer and virus leads by HTS, chemical design and SEA data mining

scientific article published in January 2009

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

scientific article published on 08 October 2009

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

scientific article

Dicubyl disulfide

scientific article

Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency

scientific article

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

scientific article published on 27 May 2008

Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response

scientific article published on 7 August 2013

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

scientific article published in March 2005

Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits

scientific article

Facile synthesis of hierarchical nanocrystalline ZSM-5 zeolite under mild conditions and its catalytic performance

scientific article

Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China

article

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

scientific article

High-throughput screening-based identification of paramyxovirus inhibitors

scientific article

Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation

scientific article published on August 2011

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin

scientific article published on 24 June 2008

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

scientific article

Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.

scientific article published on 10 January 2015

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

scientific article published on 31 December 2009

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

scientific article

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

scientific article

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics

scientific article

Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity

scientific article

Nonpeptide inhibitors of measles virus entry

scientific article published on August 2006

Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition.

scientific article

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases

scientific article

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex

scientific article published on 05 June 2008

Rolling Circle Amplification-Based Biosensors

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

scientific article

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

scientific article published on August 2013

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

scientific article published on 14 August 2008

Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system

scientific article published on June 2006

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

scientific article published on 25 April 2012

Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts.

scientific article published on May 2014

Target analysis of the experimental measles therapeutic AS-136A

scientific article

Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation

scientific article

Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa

scientific article published on 01 April 2008

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

scientific article published on 31 August 2015

Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.

scientific article

Two domains that control prefusion stability and transport competence of the measles virus fusion protein

scientific article published on February 2006

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

scientific article

List of works by Aiming Sun

3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: the persistence of axial fluorine

A target site for template-based design of measles virus entry inhibitors.

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

Antiviral atropisomers: conformational energy surfaces by NMR for host-directed myxovirus blockers

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog

Cancer and virus leads by HTS, chemical design and SEA data mining

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

Dicubyl disulfide

Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits

Facile synthesis of hierarchical nanocrystalline ZSM-5 zeolite under mild conditions and its catalytic performance

Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

High-throughput screening-based identification of paramyxovirus inhibitors

Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics

Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity

Nonpeptide inhibitors of measles virus entry

Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition.

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex

Rolling Circle Amplification-Based Biosensors

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts.

Target analysis of the experimental measles therapeutic AS-136A

Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation

Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.

Two domains that control prefusion stability and transport competence of the measles virus fusion protein

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody