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List of works by Karl-Josef Kallen

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects

scientific article published on 11 January 2017

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

scientific article published on 8 January 2015

A novel, disruptive vaccination technology: self-adjuvanted RNActive(®) vaccines

scientific article published on 04 June 2013

A phase I/IIa study of the mRNA based cancer vaccine CV9103 prepared with the RNActive technology results in distinctly longer survival than predicted by the Halabi Nomogram which correlates with the induction of antigen-specific immune responses

scientific article published on 7 November 2013

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

scientific article published on 15 February 2019

A randomized, double-blind, placebo-controlled, Phase I/II trial of RNActive®-vaccine cv9104 in patients with metastatic castrate-refractory prostate cancer (mcrpc): first results of the Phase I part

scientific article published on 6 November 2014

Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines

scientific article published in May 2003

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

scientific article

Developing mRNA-vaccine technologies

scientific article published on 12 October 2012

Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition

scientific article published in August 2004

Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy

scientific article

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

scientific article published on March 2005

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect ⬇️

scientific article published on June 1, 2012

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

scientific article

Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity

scientific article published in January 2011

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

scholarly article by Alexandros Papachristofilou et al published 8 February 2019 in Journal for Immunotherapy of Cancer

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

scientific article

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection ⬇️

scientific article published on November 25, 2012

RNAdjuvant®, a novel, highly-potent RNA-based adjuvant, combines strong immunostimulatory capacities with a favorable safety profile

scientific article published on 4 November 2015

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

scientific article published on 16 June 2015

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

scientific article

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

scientific article

The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane

scientific article

The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis

scientific article published in July 2004

The regulatory landscape for actively personalized cancer immunotherapies

article published in 2013

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10

scientific article

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex

scientific article published on January 2002

gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes

scientific article published on 6 June 2006

mRNA-based vaccines synergize with radiation therapy to eradicate established tumors

scientific article published on 15 August 2014

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