List of works by Alexander Knuth

A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma

scientific article published on 01 March 2007

A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy

scientific article (publication date: 2013)

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

scientific article published on 15 February 2019

A pooled analysis of sequential therapies with sorafenib and sunitinib in metastatic renal cell carcinoma.

scientific article published on 2 June 2012

Adjuvant treatment of resectable biliary tract cancer with cisplatin plus gemcitabine: A prospective single center phase II study

scientific article published on 11 January 2018

Aldara activates TLR7-independent immune defence

scientific article

An open invitation to the cancer immunology community

scientific article

Antigen-specific immunotherapy and cancer vaccines

scientific article

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1

scientific article published on 01 October 2011

Automated tube potential selection for standard chest and abdominal CT in follow-up patients with testicular cancer: comparison with fixed tube potential.

scientific article published on 2 May 2012

CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

scientific article

Cancer testis antigen expression in testicular germ cell tumorigenesis.

scientific article

Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets.

scientific article

Cancer-testis antigens and immunosurveillance in human cutaneous squamous cell and basal cell carcinomas.

scientific article published on 2 June 2010

Chromosomal aberrations of cancer-testis antigens in myeloma patients

scientific article published on 13 May 2014

Classification of current anticancer immunotherapies

scientific article

Clinical cancer vaccine trials

scientific article

Computed tomographic perfusion imaging for the prediction of response and survival to transarterial radioembolization of liver metastases

scientific article published in November 2013

Concomitant statin use does not impair the clinical outcome of patients with diffuse large B cell lymphoma treated with rituximab-CHOP.

scientific article published on 5 March 2010

Consensus nomenclature for CD8(+) T cell phenotypes in cancer

scientific article published on 25 February 2015

Cross-presentation of HLA class I epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APCs

scientific article published on 01 February 2003

Cryptic epitopes induce high-titer humoral immune response in patients with cancer.

scientific article

Daily Pomegranate Intake Has No Impact on PSA Levels in Patients with Advanced Prostate Cancer - Results of a Phase IIb Randomized Controlled Trial

scientific article published on 29 August 2013

Developments in cancer immunotherapy

scientific article published on 07 May 2010

Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts

scientific article published in April 2008

Efficacy of selective digestive decontamination in patients with multiple myeloma undergoing high-dose chemotherapy and autologous stem cell transplantation

scientific article published on 21 August 2018

Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients

scientific article published on 16 December 2010

Equivalence of pegfilgrastim and filgrastim in lymphoma patients treated with BEAM followed by autologous stem cell transplantation

scientific article

Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients

scientific article

Expression of MAGE-C1/CT7 and selected cancer/testis antigens in ovarian borderline tumours and primary and recurrent ovarian carcinomas

scientific article published on 26 March 2013

Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients

scientific article

Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease ⬇️

scientific article published on 06 October 2010

Frequent expression of the novel cancer testis antigen MAGE-C2/CT-10 in hepatocellular carcinoma

scientific article published on January 2009

Gemcitabine depletes regulatory T-cells in human and mice and enhances triggering of vaccine-specific cytotoxic T-cells

scientific article published on 07 January 2011

HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones.

scientific article

Humoral and cellular immune responses against the breast cancer antigen NY-BR-1: definition of two HLA-A2 restricted peptide epitopes

scientific article

Identification of a naturally processed NY-ESO-1 peptide recognized by CD8+ T cells in the context of HLA-B51.

scientific article published on 19 September 2002

Identification of cancer/testis genes by database mining and mRNA expression analysis

scientific article

Identification of new NY-ESO-1 epitopes recognized by CD4+ T cells and presented by HLA-DQ B1 03011.

scientific article published on February 2006

Identification of tumor antigens as potential target antigens for immunotherapy by serological expression cloning

scientific article published on 15 January 2004

Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum.

scientific article published on 28 June 2002

Images in cardiovascular medicine. Infarction-like electrocardiographic changes due to a myocardial metastasis from a primary lung cancer

scientific article published on 01 March 2007

Immunosuppression and lung cancer of donor origin after bilateral lung transplantation

scientific article published on 15 November 2011

Impact of Antigen Presentation on TCR Modulation and Cytokine Release: Implications for Detection and Sorting of Antigen-Specific CD8+ T Cells Using HLA-A2 Wild-Type or HLA-A2 Mutant Tetrameric Complexes

scientific article published on 01 March 2002

Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue

article published in 2001

Increased bone marrow activity on F-18-FDG PET/CT in granulocyte colony stimulating factor producing anaplastic thyroid carcinoma

scientific article published in February 2010

Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts

scientific article published in May 2010

Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.

scientific article published on 8 February 2012

Intratumoral T-cell infiltrates and MHC class I expression in patients with stage IV melanoma

scientific article published on 01 May 2005

LUD 00-009: phase 1 study of intensive course immunization with NY-ESO-1 peptides in HLA-A2 positive patients with NY-ESO-1-expressing cancer.

scientific article

Liver perfusion imaging in patients with primary and metastatic liver malignancy: prospective comparison between 99mTc-MAA spect and dynamic CT perfusion

scientific article published on 29 January 2012

Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates

scientific article published on 5 February 2014

MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer

scientific article

MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors

scientific article published on 01 June 2011

Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients

scientific article

Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients

scientific article

Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC.

scientific article published in July 2003

NY-BR-1 is a differentiation antigen of the mammary gland

scientific article

NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy

scientific article published on 5 April 2007

NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration

scientific article published on 01 June 2007

NY-ESO-1 protein glycosylated by yeast induces enhanced immune responses

scientific article published on November 2010

NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma

scientific article published on 15 July 2013

NY-ESO-1: review of an immunogenic tumor antigen

scientific article

New derivatives of vitamin B12 show preferential targeting of tumors

scientific article

Particle size and activation threshold: a new dimension of danger signaling

scientific article published on 19 March 2010

Patupilone (epothilone B) for recurrent glioblastoma: clinical outcome and translational analysis of a single-institution phase I/II trial

scientific article published on 8 June 2012

Pegfilgrastim reduces the length of hospitalization and the time to engraftment in multiple myeloma patients treated with melphalan 200 and auto-SCT compared with filgrastim

scientific article published on 13 August 2010

Phase I study of a chloroquine-gemcitabine combination in patients with metastatic or unresectable pancreatic cancer

scientific article published on 4 October 2017

Potential use of humanized antibodies in the treatment of breast cancer.

scientific article published on July 2006

Preferential nuclear and cytoplasmic NY-BR-1 protein expression in primary breast cancer and lymph node metastases

scientific article published on 01 May 2006

Prognostic factors for survival in lymphoma patients after autologous stem cell transplantation

scientific article published on 07 May 2013

Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head

scientific article published in May 2008

Quantitative computed tomography liver perfusion imaging using dynamic spiral scanning with variable pitch: feasibility and initial results in patients with cancer metastases.

scientific article published in July 2010

Quantitative perfusion analysis of malignant liver tumors: dynamic computed tomography and contrast-enhanced ultrasound.

scientific article

RP1 is a phosphorylation target of CK2 and is involved in cell adhesion

scientific article published on 03 July 2013

Radiotherapy of human sarcoma promotes an intratumoral immune effector signature.

scientific article published on 16 July 2013

Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation

scientific article published on 08 June 2012

Rational development of high-affinity T-cell receptor-like antibodies

scientific article

Recombinant vaccinia/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patients.

scholarly article

Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus

scientific article published in December 2017

Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin

scientific article published on 01 January 2007

Sequential cancer immunotherapy: targeted activity of dimeric TNF and IL-8.

scientific article

Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer

scientific article published on 11 February 2014

Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients

scientific article published on December 2006

Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma

scientific article

Structure-activity profiles of Ab-derived TNF fusion proteins.

scientific article published on August 2006

Successful Salvage Chemotherapy with FOLFIRINOX for Recurrent Mixed Acinar Cell Carcinoma and Ductal Adenocarcinoma of the Pancreas in an Adolescent Patient.

scientific article published on 28 September 2013

Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses

scientific article

Targeted therapeutic approach for an anaplastic thyroid cancer in vitro and in vivo

scientific article

Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg.

scientific article published in July 2009

Temsirolimus is highly effective as third-line treatment in chromophobe renal cell cancer

scientific article

The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer

scientific article

The discovery of cancer/testis antigens by autologous typing with T cell clones and the evolution of cancer vaccines

scientific article

Treatment of POEMS syndrome with bevacizumab

scientific article

Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma

scientific article published on March 2013

Tumor-reactive CD8+ T-cell clones in patients after NY-ESO-1 peptide vaccination

scientific article

Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenza peptides in subjects with advanced malignant melanoma

scientific article published on 16 July 2003

Urine antibody against human cancer antigen NY-ESO-1

scientific article published on 06 August 2002

Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience

article

Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer - a phase II study

scientific article

Yeast-based identification of prostate tumor antigens provides an effective vaccine platform

scientific article published on 01 March 2010

β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma

scientific article published on 29 January 2019

γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo

scientific article

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