List of works - Douglas I. Walker

A scalable workflow to characterize the human exposome

scientific article published on 22 September 2021

ADAP-GC 3.2: Graphical Software Tool for Efficient Spectral Deconvolution of Gas Chromatography-High-Resolution Mass Spectrometry Metabolomics Data.

scientific article

ADAP-GC 4.0: Application of Clustering-Assisted Multivariate Curve Resolution to Spectral Deconvolution of Gas Chromatography-Mass Spectrometry Metabolomics Data

scientific article published on 05 July 2019

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

scientific article

Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing

scientific article published on 17 August 2020

Advances in Comprehensive Exposure Assessment: Opportunities for the US Military

scientific article published on 01 December 2019

Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

scientific article published on 08 August 2020

Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards

scientific article published on 10 April 2019

An annotation database for chemicals of emerging concern in exposome research

scientific article published in July 2021

Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards

scientific article published on 01 December 2019

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China

scientific article published on 04 September 2019

Associations between Exposure to Persistent Organic Pollutants and Subsequent Body Composition Response to Bariatric Surgery

scholarly article published on 17 September 2023

Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts

scientific article published on 01 December 2019

Benzo[a]pyrene Perturbs Mitochondrial and Amino Acid Metabolism in Lung Epithelial Cells and Has Similar Correlations With Metabolic Changes in Human Serum

scientific article published on 01 December 2019

Bottled Water Consumption and Per- and Polyfluorinated Alkyl Substances (PFAS): Findings from the MetaAIR Study and NHANES 2003-2018

scholarly article published on 17 September 2023

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

scientific article published in September 2016

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

scholarly article

Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice

scientific article

Computational Metabolomics: A Framework for the Million Metabolome

scientific article published on 14 September 2016

Correction to: Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

scientific article published on 04 December 2020

Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].

scientific article published on 26 April 2017

Cross-species metabolomic analysis of tau- and DDT-related toxicity

scientific article published on 01 May 2022

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics

scientific article

Determination of thiocyanate in exhaled breath condensate

scientific article published on 22 August 2018

Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics

scientific article published on 23 December 2019

Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE⁻/⁻ mice with partial carotid ligation

scientific article

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults

scientific article published on 03 September 2020

Environmental Chemicals Altered in Association With Deployment for High Risk Areas

scientific article published on 01 December 2019

Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach

scientific article published on 16 July 2020

Exposure to DDE and BMI among adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study

scholarly article published on 17 September 2023

Exposure to per- and polyfluoroalkyl substances and plasma proteomics in young adults: The Meta-AIR study

scholarly article published on 17 September 2023

Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity

scientific article published on 31 December 2012

Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling in Caenorhabditis elegans

scientific article published on 01 April 2021

High-Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases

scientific article published on 26 November 2021

High-Resolution Metabolomics Assessment of Military Personnel: Evaluating Analytical Strategies for Chemical Detection.

scientific article published on August 2016

High-Resolution Metabolomics Study Of Occupational Exposure To Trichloroethylene ⬇️

scholarly article

High-Resolution Metabolomics for Nutrition and Health Assessment of Armed Forces Personnel.

scientific article

High-resolution metabolomic profiling of Alzheimer's disease in plasma

scientific article published on 11 December 2019

High-resolution metabolomics of occupational exposure to trichloroethylene

scientific article published on 05 October 2016

High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans

scientific article published in PLoS ONE

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

scientific article published on 14 April 2015

Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics.

scientific article published on 9 February 2018

Integrative Network Analysis Linking Clinical Outcomes With Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

scientific article published on 01 December 2019

Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan.

scientific article published on August 2016

Maternal serum metabolome and traffic-related air pollution exposure in pregnancy

scientific article published on 20 June 2019

Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.

scientific article published on August 2016

Metabolic Phenotyping in Personalized and Public Healthcare. List of Contributors

section of a book

Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan

scientific article published on 01 December 2019

Metabolome-Wide Association Study of Primary Open Angle Glaucoma.

scientific article published in July 2015

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy

scientific article published on 04 December 2018

Metabolome-wide association study of occupational exposure to benzene

journal article published in 2021

Metabolome-wide association study of phenylalanine in plasma of common marmosets

scientific article

Metabolomic assessment of exposure to near-highway ultrafine particles.

scientific article published on 5 December 2018

Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection.

scientific article published on 15 August 2017

Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study

scientific article published on 21 June 2019

Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry

scientific article

Multigenerational metabolic profiling in the Michigan PBB registry

scientific article published on 13 February 2019

P4‐480: WESTERN DIET PROMOTES CENTRAL INSULIN IMPAIRMENT AND THE DYSREGULATION OF METABOLITES ASSOCIATED WITH ALZHEIMER'S DISEASE: THE ROLE OF SOLUBLE TNF ⬇️

scholarly article

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

scientific article published in PLoS ONE

Perfluoroalkyl Substances and Metabolic Dysregulations over the Life-course: A Longitudinal Metabolome Investigation using Causal Inference Framework

scientific article published in 2023

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

scientific article published on 16 November 2019

Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis.

scientific article published on 4 March 2019

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma

scientific article published on 10 April 2019

Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

scientific article

Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.

scientific article published on 11 February 2017

Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study

scientific article

Reference Standardization for Mass Spectrometry and High-resolution Metabolomics Applications to Exposome Research

scientific article

Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics

scientific article published on 03 June 2020

Sampling interstitial fluid from human skin using a microneedle patch

scientific article published on 01 November 2020

Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

scientific article published on 14 August 2013

Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases

scientific article published on 24 December 2019

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer's disease associated with obesity, metabolic syndrome, and type 2 diabetes

scientific article published on 31 December 2019

The Exposome: Molecules to Populations

scientific article published on 10 August 2018

The metabolome: A key measure for exposome research in epidemiology

scientific article published on 26 April 2019

The need for a cancer exposome atlas: a scoping review

scientific article published on 19 December 2024

Toxic tall fescue grazing increases susceptibility of the Angus steer fecal microbiota and plasma/urine metabolome to environmental effects

scientific article published on 12 February 2020

Unsupervised dimensionality reduction for exposome research

scientific article published on 19 May 2020

Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring

scientific article published on 04 June 2020

Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation.

scientific article

Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops

scientific article published on 01 December 2019

Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution

scientific article published on 07 August 2018

xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data.

scientific article

List of works by Douglas I. Walker

A scalable workflow to characterize the human exposome

ADAP-GC 3.2: Graphical Software Tool for Efficient Spectral Deconvolution of Gas Chromatography-High-Resolution Mass Spectrometry Metabolomics Data.

ADAP-GC 4.0: Application of Clustering-Assisted Multivariate Curve Resolution to Spectral Deconvolution of Gas Chromatography-Mass Spectrometry Metabolomics Data

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing

Advances in Comprehensive Exposure Assessment: Opportunities for the US Military

Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards

An annotation database for chemicals of emerging concern in exposome research

Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China

Associations between Exposure to Persistent Organic Pollutants and Subsequent Body Composition Response to Bariatric Surgery

Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts

Benzo[a]pyrene Perturbs Mitochondrial and Amino Acid Metabolism in Lung Epithelial Cells and Has Similar Correlations With Metabolic Changes in Human Serum

Bottled Water Consumption and Per- and Polyfluorinated Alkyl Substances (PFAS): Findings from the MetaAIR Study and NHANES 2003-2018

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice

Computational Metabolomics: A Framework for the Million Metabolome

Correction to: Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].

Cross-species metabolomic analysis of tau- and DDT-related toxicity

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics

Determination of thiocyanate in exhaled breath condensate

Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics

Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE⁻/⁻ mice with partial carotid ligation

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults

Environmental Chemicals Altered in Association With Deployment for High Risk Areas

Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach

Exposure to DDE and BMI among adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study

Exposure to per- and polyfluoroalkyl substances and plasma proteomics in young adults: The Meta-AIR study

Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity

Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling in Caenorhabditis elegans

High-Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases

High-Resolution Metabolomics Assessment of Military Personnel: Evaluating Analytical Strategies for Chemical Detection.

High-Resolution Metabolomics Study Of Occupational Exposure To Trichloroethylene ⬇️

High-Resolution Metabolomics for Nutrition and Health Assessment of Armed Forces Personnel.

High-resolution metabolomic profiling of Alzheimer's disease in plasma

High-resolution metabolomics of occupational exposure to trichloroethylene

High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics.

Integrative Network Analysis Linking Clinical Outcomes With Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan.

Maternal serum metabolome and traffic-related air pollution exposure in pregnancy

Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.

Metabolic Phenotyping in Personalized and Public Healthcare. List of Contributors

Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan

Metabolome-Wide Association Study of Primary Open Angle Glaucoma.

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy

Metabolome-wide association study of occupational exposure to benzene

Metabolome-wide association study of phenylalanine in plasma of common marmosets

Metabolomic assessment of exposure to near-highway ultrafine particles.

Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection.

Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study

Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry

Multigenerational metabolic profiling in the Michigan PBB registry

P4‐480: WESTERN DIET PROMOTES CENTRAL INSULIN IMPAIRMENT AND THE DYSREGULATION OF METABOLITES ASSOCIATED WITH ALZHEIMER'S DISEASE: THE ROLE OF SOLUBLE TNF ⬇️

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

Perfluoroalkyl Substances and Metabolic Dysregulations over the Life-course: A Longitudinal Metabolome Investigation using Causal Inference Framework

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis.

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma

Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.

Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study

Reference Standardization for Mass Spectrometry and High-resolution Metabolomics Applications to Exposome Research

Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics

Sampling interstitial fluid from human skin using a microneedle patch

Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer's disease associated with obesity, metabolic syndrome, and type 2 diabetes

The Exposome: Molecules to Populations

The metabolome: A key measure for exposome research in epidemiology

The need for a cancer exposome atlas: a scoping review

Toxic tall fescue grazing increases susceptibility of the Angus steer fecal microbiota and plasma/urine metabolome to environmental effects

Unsupervised dimensionality reduction for exposome research

Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring