List of works - Bruce Chesebro

Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels

scientific article published on 26 August 2009

Analysis of two monoclonal antibodies reactive with envelope proteins of murine retroviruses: one pan specific antibody and one specific for Moloney leukemia virus

scientific article published on 17 February 2014

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

scientific article

Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection

scientific article

Biomedicine. A fresh look at BSE

scientific article published on 01 September 2004

Biomedicine. A view from the top--prion diseases from 10,000 feet

scientific article

Chronic wasting disease agents in nonhuman primates

scientific article

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes

scientific article published on March 2002

Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection

scientific article

Detection of prion infectivity in fat tissues of scrapie-infected mice

scientific article

Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types

scientific article

Disinfection and sterilization of prion-contaminated medical instruments

scientific article published on 01 December 2010

Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein

scientific article published on 21 January 2014

Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice

scientific article

Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35.

scientific article

Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

scientific article

Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein.

scientific article published on 20 February 2018

Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring

scientific article

Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro

scientific article published on 21 January 2004

Functional characteristics of HIV-1 subtype C compatible with increased heterosexual transmissibility.

scientific article

Gene expression alterations in brains of mice infected with three strains of scrapie

scientific article

Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions

scientific article

Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy

scientific article published in December 2002

Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity

scientific article

In vivo comparison of chronic wasting disease infectivity from deer with variation at prion protein residue 96.

scientific article

Inactivation of chronic wasting disease prions using sodium hypochlorite

scientific article published on 04 October 2019

Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro

scientific article

Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein

scientific article published on 25 March 2015

Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses

article

Introduction to the transmissible spongiform encephalopathies or prion diseases ⬇️

scientific article published on January 1, 2003

Knockout of fractalkine receptor Cx3cr1 does not alter disease or microglial activation in prion-infected mice

scientific article published on 02 March 2016

Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques.

scientific article

Levels of abnormal prion protein in deer and elk with chronic wasting disease

scientific article published on June 2007

Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions

scientific article published on 7 November 2011

Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

scientific article

MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis

scientific article

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

scientific article (publication date: 2005)

Microglia Are Critical in Host Defense Against Prion Disease.

scientific article

Microglia are not required for prion-induced retinal photoreceptor degeneration

scientific article published on 25 March 2019

Neuroinflammation, Microglia, and Cell-Association during Prion Disease

scientific article published in 2019

Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain

scientific article published on 25 June 2008

Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice

scientific article

Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease

scientific article published on 27 July 2016

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

scientific article

Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms.

scientific article

Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction

scientific article

Prion infectivity in fat of deer with chronic wasting disease

scientific article published on July 2009

Prion protein and susceptibility to kainate-induced seizures: genetic pitfalls in the use of PrP knockout mice

scientific article published on 12 July 2013

Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice

scientific article

Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein

scientific article published on 28 March 2009

Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein

scientific article published on 20 August 2020

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice

scientific article published on July 2006

Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesis

scientific article

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

scientific article published on 07 May 2020

Reply to Karapetyan: Viral synthesis and assembly is unlikely to occur under cell-free PMCA conditions.

scientific article

Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein

scientific article published on 21 February 2007

Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression

scientific article published on 8 April 2008

Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro

scientific article published on 16 December 2011

Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages

scientific article

Scrapie pathogenesis in brain and retina: effects of prion protein expression in neurons and astrocytes

scientific article

Scrapie-specific neuronal lesions are independent of neuronal PrP expression

scientific article published in June 2004

Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha

scientific article published on December 2004

Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice

scientific article

Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.

scientific article

Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages

scientific article

Susceptibilities of nonhuman primates to chronic wasting disease

scientific article

Toll-like receptor 2 confers partial neuroprotection during prion disease

scientific article published in PLoS ONE

Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

article

Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein

scientific article

Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

scientific article published on 19 June 2013

List of works by Bruce Chesebro

Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels

Analysis of two monoclonal antibodies reactive with envelope proteins of murine retroviruses: one pan specific antibody and one specific for Moloney leukemia virus

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection

Biomedicine. A fresh look at BSE

Biomedicine. A view from the top--prion diseases from 10,000 feet

Chronic wasting disease agents in nonhuman primates

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes

Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection

Detection of prion infectivity in fat tissues of scrapie-infected mice

Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types

Disinfection and sterilization of prion-contaminated medical instruments

Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein

Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice

Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35.

Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein.

Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring

Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro

Functional characteristics of HIV-1 subtype C compatible with increased heterosexual transmissibility.

Gene expression alterations in brains of mice infected with three strains of scrapie

Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions

Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy

Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity

In vivo comparison of chronic wasting disease infectivity from deer with variation at prion protein residue 96.

Inactivation of chronic wasting disease prions using sodium hypochlorite

Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro

Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein

Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses

Introduction to the transmissible spongiform encephalopathies or prion diseases ⬇️

Knockout of fractalkine receptor Cx3cr1 does not alter disease or microglial activation in prion-infected mice

Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques.

Levels of abnormal prion protein in deer and elk with chronic wasting disease

Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions

Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

Microglia Are Critical in Host Defense Against Prion Disease.

Microglia are not required for prion-induced retinal photoreceptor degeneration

Neuroinflammation, Microglia, and Cell-Association during Prion Disease

Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain

Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice

Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms.

Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction

Prion infectivity in fat of deer with chronic wasting disease

Prion protein and susceptibility to kainate-induced seizures: genetic pitfalls in the use of PrP knockout mice

Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice

Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein

Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice

Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesis

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Reply to Karapetyan: Viral synthesis and assembly is unlikely to occur under cell-free PMCA conditions.

Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein

Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression

Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro

Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages

Scrapie pathogenesis in brain and retina: effects of prion protein expression in neurons and astrocytes

Scrapie-specific neuronal lesions are independent of neuronal PrP expression

Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha

Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice

Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.

Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages

Susceptibilities of nonhuman primates to chronic wasting disease

Toll-like receptor 2 confers partial neuroprotection during prion disease

Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein

Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein