Search filters

List of works by Katherine I. O'Rourke

A collaborative Canadian-United Kingdom evaluation of an immunohistochemistry protocol to diagnose bovine spongiform encephalopathy

scientific article

A prion protein epitope selective for the pathologically misfolded conformation

scientific article

A processed pseudogene contributes to apparent mule deer prion gene heterogeneity

scientific article published on February 2004

A species barrier limits transmission of chronic wasting disease to mink (Mustela vison).

scientific article published on April 2008

A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation

scientific article published on March 2016

Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease

scientific article published in July 2003

Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep

scientific article

Active surveillance for scrapie by third eyelid biopsy and genetic susceptibility testing of flocks of sheep in Wyoming

scientific article

Antemortem Detection of PrPCWD in Preclinical, Ranch-Raised Rocky Mountain Elk (Cevvus Elaphus Nelsoni) by Biopsy of the Rectal Mucosa

scientific article published on 01 January 2009

Assessment of the genetic risk and impact of lateral transmission in a valine-associated scrapie outbreak in sheep

scientific article published in August 2005

Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk

scientific article

Associations between genotypes at codon 171 and 136 of the prion protein gene and production traits in market lambs

scientific article published in October 2007

Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks

scientific article published on 01 November 2004

Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep

scientific article published in May 2009

CD21-positive follicular dendritic cells: A possible source of PrPSc in lymph node macrophages of scrapie-infected sheep

scientific article published on April 2003

Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats

scientific article published on 25 January 2012

Chronic wasting disease in a Wisconsin white-tailed deer farm

scientific article published in September 2008

Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: comparative analysis of the scrapie prion protein ⬇️

scientific article published on 7 December 2005

Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models.

scientific article

Chronic wasting disease prions in elk antler velvet

scientific article

Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays

scientific article published on 24 December 2014

Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma

scientific article

Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of cap

scientific article published in January 2002

Comparison of two automated immunohistochemical procedures for the diagnosis of scrapie in domestic sheep and chronic wasting disease in North American white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus).

scientific article

Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice

scientific article published on 23 July 2011

Detection of the abnormal isoform of the prion protein associated with chronic wasting disease in the optic pathways of the brain and retina of Rocky Mountain elk (Cervus elaphus nelsoni).

scientific article published on 9 April 2010

Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America

scientific article published on 01 September 2012

Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay

scientific article published on 16 June 2012

Distribution of protease-resistant prion protein and spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease

scientific article published in September 2002

Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placenta

scientific article

Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging cow elk (Cervus elaphus nelsoni).

scientific article published in April 2013

Elk with a long incubation prion disease phenotype have a unique PrPd profile.

scientific article published in December 2007

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion

scientific article

Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease

scientific article published on July 2005

Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease

scientific article published on September 2000

Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): early detection and late stage distribution of protease-resistant prion protein.

scientific article

Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus)

scientific article

Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route.

scientific article published in May 2008

Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route

scientific article published in May 2005

Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222.

scientific article published on 4 April 2012

Failure of fallow deer (Dama dama) to develop chronic wasting disease when exposed to a contaminated environment and infected mule deer (Odocoileus hemionus).

scientific article

Fewer PrPc myeloid-based cells in sheep with the prion-resistant genotype.

scientific article

Identification of atypical scrapie in Canadian sheep

scientific article published on 01 May 2010

Immunization with a synthetic peptide vaccine fails to protect mule deer (Odocoileus hemionus) from chronic wasting disease

scientific article published in July 2013

Immunohistochemical detection and distribution of prion protein in a goat with natural scrapie

scientific article published in March 2003

Immunohistochemical detection of Prion protein (PrP-Sc) and epidemiological study of BSE in Korea

scientific article published on April 1, 2001

Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue

scientific article

Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay

scientific article

Investigation of the effects of experimental autolysis on the detection of abnormal prion protein in lymphoid and central nervous system tissues from elk and sheep using the Western blotting method.

scientific article published on January 2011

Molecular genealogy tools for white-tailed deer with chronic wasting disease.

scientific article

Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein.

scientific article

Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.

scientific article published on 22 April 2008

Nor98 scrapie identified in the United States

scientific article published in July 2009

Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)

scientific article published on 01 October 1999

Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock.

scientific article published on 22 January 2009

PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay

scientific article published in May 2015

Pathogen-mediated selection in free-ranging elk populations infected by chronic wasting disease

scientific article published on 30 October 2017

Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer

scientific article published in May 2004

PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States

scientific article published on 01 April 1997

PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease

scientific article published in October 1999

PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus.

scientific article published in April 2006

Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy

scientific article published in October 2002

Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue

scientific article

Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep

scientific article

Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle

scientific article published in January 2001

Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation

scientific article published in January 2006

Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein

scientific article published on 08 July 2016

Prion genotypes of scrapie-infected Canadian sheep 1998-2008 ⬇️

scientific article published on July 1, 2010

Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease

scientific article

Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use

scientific article published on June 2004

Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie

scientific article published in June 2015

Scrapie resistance in ARQ sheep.

scientific article published on 16 July 2008

Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells

scientific article published on 06 August 2008

Sparse PrP(Sc) accumulation in the placentas of goats with naturally acquired scrapie

scientific article

Spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus) and Rocky Mountain elk (Cervus elaphus nelsoni) in northcentral Colorado

scientific article published in January 1997

The incidence of genotypes at codon 171 of the prion protein gene (PRNP) in five breeds of sheep and production traits of ewes associated with those genotypes

scientific article published in February 2005

The placenta shed from goats with classical scrapie is infectious to goat kids and lambs

scientific article published on 17 April 2015

The role of genetics in chronic wasting disease of North American cervids

scientific article published on April 2012

Transmissibility of caprine scrapie in ovine transgenic mice.

scientific article

Transmission of transmissible mink encephalopathy to raccoons (Procyon lotor) by intracerebral inoculation

scientific article published in January 2004

Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease

scientific article published in January 2002

Validation of use of rectoanal mucosa-associated lymphoid tissue for immunohistochemical diagnosis of chronic wasting disease in white-tailed deer (Odocoileus virginianus).

scientific article published on 4 March 2009

Variable patterns of distribution of PrP(CWD) in the obex and cranial lymphoid tissues of Rocky Mountain elk (Cervus elaphus nelsoni) with subclinical chronic wasting disease

scientific article published on 01 September 2004

Paulina is supported by:

About Paulina

Help