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List of works by Evan Begg

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

scientific article published in January 2002

A comparison of efficacy and tolerance of the short acting sedatives midazolam and zopiclone

scientific article published on October 28, 1992

A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time

scientific article

A review of limited lists and formularies: are they cost-effective?

scientific article

A sequential Bayesian algorithm for dose individualisation of carboplatin

scientific article

A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma

scientific article published on 12 November 2012

A suggested approach to once‐daily aminoglycoside dosing ⬇️

scientific article published on June 1, 1995

A unified pharmacokinetic approach to individualized drug dosing.

scientific article

Adaptive resistance following single doses of gentamicin in a dynamic in vitro model.

scientific article

Adaptive resistance to tobramycin in Pseudomonas aeruginosa lung infection in cystic fibrosis

scientific article published on 01 June 1996

Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects.

scientific article published on December 2011

Aminoglycoside adaptive resistance: importance for effective dosage regimens

scientific article

Aminoglycoside dosage regimens after therapeutic drug monitoring

scientific article published on 01 January 2002

Aminoglycoside dosing: time to change

scientific article

Aminoglycoside toxicity and relation to dose regimen.

scientific article published on January 1994

Aminoglycosides--50 years on

scientific article published in June 1995

An extended interval dosing method for gentamicin in neonates ⬇️

scientific article published on 01 December 2001

Antimicrobial effects of lomefloxacin in vitro

scientific article published on 01 April 1991

Application of a simplified method to determine bioavailability of an oral dose of phenytoin

scientific article published in April 1993

Are Gentamicin and/or Vancomycin Associated with Ototoxicity in the Neonate? A Retrospective Audit ⬇️

scientific article published on January 1, 2011

Asthma management at Christchurch Hospital: compliance with guidelines

scientific article published on April 1996

Breastfeeding during tacrolimus therapy

scientific article published in February 2006

CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure

scientific article published on 14 April 2009

Cimetidine does not appear to influence the distribution of metformin into human milk

scientific article published on 9 June 2008

Circadian pharmacokinetics of methotrexate

scientific article published on 01 January 1989

Clarifying the American Society of Clinical Oncology practice guideline for chemotherapy dosing for obese adults

scientific article published on 10 September 2012

Clinical pharmacology: principles and practice of drug therapy in medical education.

scientific article

Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia.

scientific article

Co-administered oral metoclopramide does not enhance the rate of absorption of oral diazepam

scientific article published in May 1988

Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran

scientific article

Comment: Breast-feeding during maternal use of azathioprine

scientific article published on 27 March 2007

Comparative effects of ciprofloxacin and lomefloxacin on the oxidative metabolism of theophylline

scientific article published on April 1990

Comparing dose prediction software used to manage gentamicin dosing

scientific article published in May 2013

Comparison of gentamicin dosing regimens using an in-vitro model.

scientific article published in April 1992

Comparison of two Bayesian approaches to dose-individualization for once-daily aminoglycoside regimens

scientific article published on February 1997

Compliance with guidelines results in appropriate ondansetron prescribing at Christchurch Hospital.

scientific article published on April 1996

Concentrations of beta-blocking drugs in human milk

scientific article published on 01 January 1990

Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C

scientific article

Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status

scientific article published in October 2003

Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia

scientific article published in June 2002

Dabigatran in patients with mechanical heart valves

scientific article published in January 2014

Deaths at Christchurch Hospital

scientific article published on June 26, 1998

Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay

scientific article

Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry ⬇️

scientific article published on November 10, 2010

Determination of imatinib and its active metabolite N-desmethyl imatinib in human plasma by liquid chromatography/tandem mass spectrometry

scientific article published on 3 August 2012

Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry.

scientific article published on 21 July 2009

Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay

scientific article

Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma

scientific article published on 20 February 2008

Development of a general method of limited sampling for the determination of AUC for a drug that displays two-compartment pharmacokinetics

article

Digoxin therapeutic drug monitoring: an audit and review.

scientific article published on 12 December 2003

Distribution and excretion of fluoxetine and norfluoxetine in human milk

scientific article

Distribution of R‐ and S‐methadone into human milk during multiple, medium to high oral dosing ⬇️

scientific article published on December 1, 2001

Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin?

scientific article published on 23 September 2008

Dosing of dabigatran etexilate in relation to renal function and drug interactions at a tertiary hospital ⬇️

scientific article published on July 1, 2013

Dosing regimens of captopril and enalapril in elderly patients and those with renal insufficiency

scientific article published on 01 November 1987

Drugs in human milk. Clinical pharmacokinetic considerations

scientific article published on April 1988

Editors' Report 2004.

scientific article published in July 2005

Editors' Report 2005.

scientific article published in May 2006

Editors' Report for 2006.

scientific article

Editors' review of 2006 and the BJCP prize

scientific article published on January 2007

Effect of idazoxan on evening melatonin plasma concentrations in healthy volunteers

scientific article published on 01 August 1989

Effect of pregnancy on the pharmacokinetics of metformin

scientific article published in March 2006

Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination

scientific article published on 01 March 1983

Efficacies of different vancomycin dosing regimens against Staphylococcus aureus determined with a dynamic in vitro model.

scientific article published on October 1994

Eight years' experience of an extended-interval dosing protocol for gentamicin in neonates

scientific article published on 19 March 2009

Encouraging consensus cost effective drug therapy: five years experience with a hospital drug utilisation review programme

scientific article published on March 1997

Endogenous ouabain is not ouabain

scientific article published on 7 July 2014

Enhanced metabolism of mexiletine after phenytoin administration

scientific article

Experience of once-daily aminoglycoside dosing using a target area under the concentration-time curve

scientific article published on 01 June 1995

Exploring hospice patients' views about participating in research

scientific article published on 30 December 2011

Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs

scientific article

Fifteen years of drug information in Christchurch Hospital

scientific article published on September 14, 2001

Fluoxetine distribution in human milk

scientific article published on 01 November 1996

Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion

scientific article published in September 2002

Free drug metabolic clearance in elderly people.

scientific article

Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine

scientific article published on 01 December 2000

Genotyping for drug-metabolizing enzymes--does the promise meet the reality?

scientific article

Gentamicin and renal function: lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin

scientific article published on 1 February 2015

Health care, funding and oratory

scientific article published on June 12, 1998

Hospital drug therapy cost containment through a preferred medicines list and drug utilisation review system.

scientific article published on March 1994

How the pharmacogenetics of cytochrome P450 enzymes may affect prescribing

scientific article

How vancomycin is used in Australasia - A survey

scientific article published on 01 December 1993

Hypertension and heart failure.

scientific article published on January 1997

Improved efficacy with nonsimultaneous administration of first doses of gentamicin and ceftazidime in vitro ⬇️

scientific article published on January 1, 1995

In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances.

scientific article

Inadvertent intra-arterial injection. A problem of drug abuse

scientific article published on 01 November 1980

Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people

scientific article

Independent nurse prescribing in New Zealand

scientific article published on 11 November 2005

Individualised aminoglycoside dosage based on pharmacokinetic analysis is superior to dosage based on physician intuition at achieving target plasma drug concentrations

scientific article

Individualized drug and dose: the clinical pharmacologist's calling or curse?

scientific article

Individualizing drug therapy, and 'men behaving badly'.

scientific article published on November 2004

Institutional profile: The Carney Centre for Pharmacogenomics: a New Zealand focus for personalized medicine research

scientific article published in June 2012

Interactions between non-steroidal anti-inflammatory drugs and antihypertensives and diuretics

scientific article

Intratympanic Versus Intravenous Delivery of Dexamethasone and Dexamethasone Sodium Phosphate to Cochlear Perilymph ⬇️

scientific article published on 01 August 2011

Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph

scientific article published in December 2007

Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?

scientific article

Lansoprazole pharmacokinetics differ in patients with oesophagitis compared to healthy volunteers

scientific article published on 01 September 1999

Learning more from the dabigatran concentrations in the RE-LY study

scientific article published on 26 March 2014

Linear IgA dermatosis with severe arthralgia

scientific article published on 01 January 1991

Management of raised blood pressure

scientific article published on 1 January 1994

Management of raised blood pressure in New Zealand

scientific article published on 1 January 1993

Measurement of total phospholipids in urine of patients treated with gentamicin

scientific article

Metformin increases plasma ghrelin in Type 2 diabetes

scientific article

Metformin therapy and diabetes in pregnancy

scientific article published on 01 August 2004

Modelling of the passage of drugs into milk

scientific article published on September 1993

New government, same narrow vision. Health authorities in New Zealand have spin doctors to produce good news

scientific article published in April 1998

No significant effect of cimetidine on the pharmacokinetics of misonidazole in man

scientific article

No significant effect of metoclopramide on misonidazole elimination in man.

scientific article

Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?

scientific article

Once-daily aminoglycoside therapy: potential ototoxicity

scientific article published on 01 April 1997

Paroxetine in human milk

scientific article

Partitioning of drugs into human milk

scientific article published on January 1991

Patients "falling through the cracks". The Canterbury Charity Hospital: initial progress report

scientific article published on 13 August 2010

Perspective on dabigatran etexilate dosing: why not follow standard pharmacological principles?

scientific article

Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease

scientific article published on 1 January 2006

Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?

scientific article published in May 2005

Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.

scientific article published on January 2012

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice

scientific article

Pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failure

scientific article published on 01 November 1986

Pharmacokinetics and efficacy of rectal versus oral sustained-release morphine in cancer patients

scientific article

Pharmacokinetics of gentamicin in 957 patients with varying renal function dosed once daily.

scientific article

Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model

scientific article

Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics

scientific article

Prediction of drug concentrations in human skim milk from plasma protein binding and acid-base characteristics

scientific article

Prediction of drug distribution into human milk from physicochemical characteristics

scientific article published in February 1990

Prediction of infant drug exposure through breastfeeding: population PK modeling and simulation of fluoxetine exposure.

scientific article

Prediction of milk/plasma concentration ratio of drugs

scientific article published on 1 January 2004

Prescribing and monitoring clozapine in Christchurch

scientific article published on August 2008

Prescribing in pregnancy and lactation

scientific article published in May 2008

Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

scientific article published on 12 September 2019

Prospective evaluation of a model for the prediction of milk:plasma drug concentrations from physicochemical characteristics

scientific article

Prospective, randomized, controlled study comparing two dosing regimens of gentamicin/oral ciprofloxacin switch therapy for acute pyelonephritis

scientific article published on 01 September 1996

Protein binding of cefazolin is saturable in vivo both between and within patients

scientific article

Quantification of infant exposure to celecoxib through breast milk

scientific article published in January 2006

Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS

scientific article published on 01 April 2011

Quinapril and its metabolite quinaprilat in human milk

scientific article

Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk

scientific article published in January 2002

Reaffirming professionalism in medicine

scientific article published on 1 August 2001

Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease

scientific article published in October 2007

Reference pricing--is it in the public interest?

scientific article

Reimbursement of pharmaceuticals in New Zealand: comments on PHARMAC's processes.

scientific article

Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients

scientific article published in September 1988

Renal failure does not impair the metabolism of morphine

scientific article published on July 1986

Rifampicin and dabigatran etexilate: a place for laboratory coagulation monitoring.

scientific article published on February 2013

Serum aminoglycoside clearance is predicted as poorly by renal aminoglycoside clearance as by creatinine clearance in critically ill patients

scientific article published on 01 August 1991

Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma

scientific article published on 1 December 2018

Single or multiple daily doses of aminoglycosides. Exposure to aminoglycosides should be monitored during treatment

scientific article published in August 1996

Stability of benzylpenicillin during continuous home intravenous therapy

scientific article published on 10 March 2004

Studying drugs in human milk: time to unify the approach.

scientific article

Terfenadine ineffective in the prophylaxis of exercise-induced pruritus

scientific article published on 01 April 1992

The 'apparent clearance' of free phenytoin in elderly vs. younger adults

scientific article

The British Journal of Clinical Pharmacology Editors' Report for 2002.

scientific article published in April 2003

The British Journal of Clinical Pharmacology Editors’ Report for 2003.

scientific article published in May 2004

The Christchurch Hospital drug information service: organisation and an audit of the first 300 questions answered

scientific article published on 01 August 1987

The Effects of Pathophysiological Increments in Brain Natriuretic Peptide in Left Ventricular Systolic Dysfunction ⬇️

scientific article published on September 1, 1997

The Journal moves online for submission and peer review

scientific article

The Stent report, one year on. Christchurch Hospital's Medical Specialists Association

scientific article published on 1 July 1999

The binding of drugs to major human milk whey proteins

scientific article

The dosing and monitoring of vancomycin: what is the best way forward?

scientific article published on 29 December 2018

The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitro

scientific article published on 01 November 1996

The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil

scientific article

The management of mildly raised blood pressure in New Zealand: an alternative view

scientific article published on 1 June 1996

The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance

scientific article

The performances of the Cockcroft-Gault, modification of diet in renal disease study and chronic kidney disease epidemiology collaboration equations in predicting gentamicin clearance.

scientific article published on 17 September 2013

The pharmacokinetics and pharmacodynamics of quinapril and quinaprilat in renal impairment

scientific article

The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients

scientific article published on 30 December 2011

The pharmacokinetics of angiotensin converting enzyme inhibitors in patients with renal impairment

scientific article published on September 1989

The pharmacokinetics of corticosteroid agents

scientific article

The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing

scientific article

The pharmacokinetics of quinapril and quinaprilat in patients with congestive heart failure

scientific article

The practice of digoxin therapeutic drug monitoring

scientific article published on 12 December 2003

The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care

scientific article

The therapeutic monitoring of antimicrobial agents

scientific article

The therapeutic monitoring of antimicrobial agents.

scientific article

The use of a change in gentamicin clearance as an early predictor of gentamicin-induced nephrotoxicity

scientific article published in October 2003

Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold

scientific article published on 7 May 2008

Thiopurine treatment in inflammatory bowel disease

scientific article published on 1 January 2007

Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: can the strategy be improved?

scientific article published in February 2014

Today's science, tomorrow's medicines

scientific article published in January 2006

Transfer of metformin into human milk

scientific article

Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants

scientific article published in August 2003

Transfer of risperidone and 9-hydroxyrisperidone into human milk

scientific article published on 30 December 2003

Transfer of rofecoxib into human milk

scientific article published on 10 June 2005

Treatment of theophylline poisoning with haemoperfusion

scientific article published on January 27, 1988

Two cases of severe liver injury possibly related to 5-fluorouracil and calcium folinate

scientific article published on 01 May 2007

Two cases of thiopurine methyltransferase (TPMT) deficiency--a lucky save and a near miss with azathioprine

scientific article publishedin October 2006

Vancomycin toxicity. What is the evidence for dose dependency?

scientific article published on January 1994

Variability in the elimination of mianserin in elderly patients

scientific article

What is the evidence for once-daily aminoglycoside therapy?

scientific article published in July 1994

Why monitor peak vancomycin concentrations?

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