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List of works by Christopher T. Walsh

A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus ⬇️

scientific article published on 24 October 2012

A chemoenzymatic approach to glycopeptide antibiotics

scientific article published in November 2004

A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins

scientific article published on September 2009

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

scientific article

A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway

scientific article published on 26 April 2011

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth

scholarly article

A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis

scientific article published on 19 August 2008

A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection

scientific article published on 27 March 2006

A singular enzymatic megacomplex from Bacillus subtilis

scholarly article

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases

scientific article published in August 2005

A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis

scientific article

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines

scientific article published on 25 July 2007

Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry

scientific article published on February 2006

AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.

scientific article published in April 2004

AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

scientific article

Aminobenzoates as building blocks for natural productassembly lines ⬇️

scientific article published on November 8, 2011

An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes

scientific article

An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo

scientific article published on 02 July 2008

An enzymatic cyclopentyl[b]indole formation involved in scytonemin biosynthesis

scientific article

An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins

scientific article published on July 2013

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

scholarly article

Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming

scientific article

Antimicrobials

scientific article published on 3 September 2009

Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

scientific article published on 17 May 2017

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009 ⬇️

scientific article

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.

scientific article published in November 2004

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

scientific article

Biochemistry. Directing biosynthesis

scientific article published in October 2006

Biological formation of pyrroles: nature's logic and enzymatic machinery

scientific article published on 15 June 2006

Biologically generated carbon dioxide: nature's versatile chemical strategies for carboxy lyases

scientific article published on 10 May 2019

Biosynthesis of (-)-(1S,2R)-allocoronamic acyl thioester by an Fe(II)-dependent halogenase and a cyclopropane-forming flavoprotein

scientific article published on 2 October 2008

Biosynthesis of Piperazic Acid via N5‐Hydroxy‐Ornithine in Kutzneria spp. 744 ⬇️

scientific article published on April 20, 2012

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces

scientific article published in August 2003

Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster

scientific article

Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

scientific article published on 20 June 2011

Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate

scientific article published on 31 October 2007

BluB cannibalizes flavin to form the lower ligand of vitamin B12

scientific article

Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase.

scientific article

Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases

scientific article

Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.

scientific article

Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation

scientific article published on February 2009

Catalytic mapping of the vibriobactin biosynthetic enzyme VibF.

scientific article published in January 2002

Catalytically inactive condensation domain C1 is responsible for the dimerization of the VibF subunit of vibriobactin synthetase

scientific article published in September 2004

Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-d-xylo-4-hexulose 3-epimerase

article

Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine

scientific article

Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring

scientific article (publication date: 2004)

Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line

scientific article published on 01 January 2007

Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster

scientific article published in November 2005

Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin

scholarly article

Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies

scientific article

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

scientific article published on 8 August 2007

Characterization of the aminocarboxycyclopropane-forming enzyme CmaC

scientific article published on 01 January 2007

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway

scientific article

Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line

scientific article published on 01 August 2006

Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis

scientific article

Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase

scientific article published in November 2002

Chemical logic and enzymatic machinery for biological assembly of peptidyl nucleoside antibiotics

scientific article published on 25 August 2011

Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7†

scientific article published in 2007

Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry.

scientific article published in November 2005

Chirality of Peptide Bond-Forming Condensation Domains in Nonribosomal Peptide Synthetases: The C5 Domain of Tyrocidine Synthetase Is a DCL Catalyst ⬇️

scientific article published on October 21, 2003

Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases

scientific article

CloQ, a prenyltransferase involved in clorobiocin biosynthesis

scientific article

Cloning and characterization of the biosynthetic gene cluster for kutznerides.

scholarly article

CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway

scientific article

Codon Randomization for Rapid Exploration of Chemical Space in Thiopeptide Antibiotic Variants ⬇️

scientific article published on December 21, 2012

Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

scholarly article

Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis

scientific article published in February 2002

Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

scientific article published on 01 February 2015

CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis

scientific article

Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis.

scientific article published in June 2007

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

scientific article published in August 2005

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

scientific article published on 15 July 2015

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

scientific article published in Nature

Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

scientific article

Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides

scientific article published on 25 October 2008

Crystallization and preliminary X-ray analysis of the O-methyltransferase NovP from the novobiocin-biosynthetic cluster of Streptomyces spheroides

scientific article published on 28 February 2007

Crystallization and preliminary X-ray studies on the putative dTDP sugar epimerase NovW from the novobiocin biosynthetic cluster of Streptomyces spheroides

scientific article published on 23 July 2003

Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase

scientific article

Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC

scientific article

Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan

scientific article published on September 2009

Determination of all nOes in 1H-13C-Me-ILV-U-2H-15N proteins with two time-shared experiments.

scientific article

Dichlorination and bromination of a threonyl-S-carrier protein by the non-heme Fe(II) halogenase SyrB2

scientific article published on 01 May 2006

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis

scientific article

Dihydrophenylalanine: A Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis ⬇️

scientific article published on September 23, 2011

Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies

scientific article published in January 2003

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

scientific article

Directed evolution of aryl carrier proteins in the enterobactin synthetase

scholarly article

Dissection of the EntF condensation domain boundary and active site residues in nonribosomal peptide synthesis

scientific article

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

scientific article

DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway

scientific article published in September 2004

EcdGHK Are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold ⬇️

scientific article published on March 11, 2013

Editorial: natural products themed issue

Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme

scientific article published in April 2005

Enzymatic Cascade Reactions in Biosynthesis

scientific article published on 20 February 2019

Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces

scientific article published on April 2002

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

scientific article

Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.

scientific article

Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis

scientific article

Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition

scientific article published on 01 February 2006

Enzymatic tailoring of ornithine in the biosynthesis of the Rhizobium cyclic trihydroxamate siderophore vicibactin ⬇️

scientific article published on October 2009

Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa

scientific article

Evidence for a monomeric structure of nonribosomal Peptide synthetases

scientific article published in September 2002

Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity

scientific article

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry

scientific article published on October 2006

FenF: servicing the Mycosubtilin synthetase assembly line in trans.

scientific article published in April 2007

Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

scientific article published on 26 April 2007

Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics

scientific article published in January 2002

From thioesters to amides and back: condensation domain reversibility in the biosynthesis of vibriobactin

scientific article published in January 2008

Fungal Indole Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway in Penicillium aethiopicum ⬇️

scientific article published on February 7, 2011

Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.

scientific article published on 25 July 2008

Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains

scientific article

Generation of Thiocillin Ring Size Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus ⬇️

scientific article published on June 15, 2012

Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. ⬇️

scientific article published on December 2009

Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.

scientific article

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

scientific article published on 19 October 2005

Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases

scientific article

Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display

scientific article

GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin

scientific article published on 01 December 2006

Glycopeptide and lipoglycopeptide antibiotics

scientific article

Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis

scientific article published on 01 March 2006

Halogenation strategies in natural product biosynthesis

scientific article

How nature morphs peptide scaffolds into antibiotics

scientific article published on January 2009

How pathogenic bacteria evade mammalian sabotage in the battle for iron

scientific article

Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation

scientific article published in November 2004

Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

scientific article published on October 2012

Identification of Phenylalanine 3-Hydroxylase for meta-Tyrosine Biosynthesis ⬇️

scientific article published on May 31, 2011

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.

scientific article

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus ⬇️

scientific article

Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans ⬇️

scientific article published on July 25, 2011

In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum.

scientific article

In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.

scientific article

In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes.

scientific article published on August 2005

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides

scientific article

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

scientific article

Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.

scientific article published on July 2007

Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics.

scientific article published on January 2008

Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

scientific article

Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1.

scientific article

Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection

scientific article published in August 2006

Introduction: antibiotic resistance

scientific article published in February 2005

Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin

scientific article published on 28 October 2008

Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics

scientific article published on 9 August 2008

Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin

scientific article published on 28 July 2007

Labeling proteins with small molecules by site-specific posttranslational modification.

scientific article

Lessons from natural molecules

scientific article

Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains

scientific article published in September 2003

Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection.

scientific article

Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants

scientific article

Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton

scholarly article

Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis

scientific article

Maturation of an <i>Escherichia coli</i> Ribosomal Peptide Antibiotic by ATP-Consuming N−P Bond Formation in Microcin C7

scientific article published in 2008

Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7.

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Morphing peptide backbones into heterocycles

scholarly article

NRPS substrate promiscuity diversifies the xenematides ⬇️

scientific article

Natural products version 2.0: connecting genes to molecules.

scientific article

Nature Builds Macrocycles and Heterocycles into Its Antimicrobial Frameworks: Deciphering Biosynthetic Strategy

scientific article published on 23 July 2018

Nature's inventory of halogenation catalysts: oxidative strategies predominate

scientific article

New antibiotics from bacterial natural products

scientific article published on December 2006

New ways to squash superbugs

scientific article published on 01 July 2009

Nine Enzymes Are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics ⬇️

scientific article published on March 18, 2011

Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid

scientific article published on February 2008

Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins

scientific article published on May 2006

Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin

scientific article published on 17 August 2007

Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation

scientific article published in August 2003

Peptidyl thiophenols as substrates for nonribosomal peptide cyclases

scientific article published in January 2004

Phagemid encoded small molecules for high throughput screening of chemical libraries

scientific article published in October 2004

Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis

scientific article published on 12 August 2008

Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites

scientific article

Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry

scientific article

Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.

scientific article published in October 2006

Protein posttranslational modifications: the chemistry of proteome diversifications

scientific article

Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway

scientific article

Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery

scientific article

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

scientific article

Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase

scientific article published in February 2004

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

scholarly article

Short Pathways to Complexity Generation: Fungal Peptidyl Alkaloid Multicyclic Scaffolds from Anthranilate Building Blocks ⬇️

scientific article published on 04 June 2013

Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling

scientific article published on September 2005

Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase

scientific article published on November 2003

Site-specific protein labeling by Sfp phosphopantetheinyl transferase

scientific article published on 01 January 2006

Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid

scientific article

Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis

scientific article published on September 2009

Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis ⬇️

scientific article

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

scientific article

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

scientific article

Structural insights into nonribosomal peptide enzymatic assembly lines

scientific article published on 22 May 2009

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

scientific article

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product

scientific article published on 7 February 2017

Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway

scientific article published on 01 September 2003

SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

scientific article

Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons

scientific article published in January 2005

Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly

scientific article published on 2 October 2008

Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation

scientific article published on 12 August 2007

The 1.6-Å resolution crystal structure of NovW: A 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

article

The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics

scientific article

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

scientific article

The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction † , ‡

scientific article

The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria ⬇️

scientific article published on September 2, 2010

The State of the Art of Chemical Biology

scientific article published on 01 January 2009

The evolution of gene collectives: How natural selection drives chemical innovation.

scholarly article

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis ⬇️

scholarly article

The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity

scientific article published on 02 May 2007

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.

scholarly article

The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.

scientific article

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds ⬇️

scientific article published on May 6, 2013

The structural basis for induction of VanB resistance

scientific article published in August 2002

The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins

scientific article

Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

scientific article

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

scholarly article

Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks ⬇️

scientific article published on January 17, 2012

Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.

scientific article

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

scientific article published on 23 May 2008

Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line

scientific article published in September 2002

Vancomycin assembly: nature's way.

scientific article

beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae

scientific article published on October 2008

tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics ⬇️

scientific article published on July 11, 2011

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