Search filters

List of works by Garold S Yost

3-Methylindole is mutagenic and a possible pulmonary carcinogen

scientific article published on 21 August 2009

3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively

scientific article

3-methylindole-induced toxicity to human bronchial epithelial cell lines

scientific article published on February 2003

A novel method to detect unlabeled inorganic nanoparticles and submicron particles in tissue by sedimentation field-flow fractionation

scientific article

Acute interstitial pneumonia in feedlot cattle: effects of feeding feather meal or vitamin E.

scientific article published on April 2007

Benzene metabolism in human lung cell lines BEAS-2B and A549 cells overexpressing CYP2F1

journal article published in 2004

Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung

scientific article

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

scientific article

CYP3A4-Mediated oxygenation versus dehydrogenation of raloxifene

scientific article

Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells

scientific article published on January 2005

Capsaicinoids Cause Inflammation and Epithelial Cell Death through Activation of Vanilloid Receptors ⬇️

scientific article published on May 1, 2003

Characterization of Pulmonary CYP4B2, Specific Catalyst of Methyl Oxidation of 3-Methylindole ⬇️

scientific article published on May 1, 2003

Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif

scientific article

Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen ⬇️

scientific article published on June 4, 2012

Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury ⬇️

scientific article published on September 23, 2011

Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter

scientific article

Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts

scientific article published on 27 February 2007

Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process

scientific article published on 14 May 2007

Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions

scientific article published on 12 December 2008

Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry

scientific article published in September 2002

Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli

scientific article

Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.

scientific article

Effect of dietary melengestrol acetate on the incidence of acute interstitial pneumonia in feedlot heifers

scientific article

Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles

scientific article

Effects of feeding aspirin and supplemental vitamin E on plasma concentrations of 3-methylindole, 3-methyleneindolenine-adduct concentrations in blood and pulmonary tissues, lung lesions, and growth performance in feedlot cattle

scientific article (publication date: December 2002)

Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells

scientific article published on 22 November 2005

Electrophilic Components of Diesel Exhaust Particles (DEP) Activate Transient Receptor Potential Ankyrin-1 (TRPA1): A Probable Mechanism of Acute Pulmonary Toxicity for DEP ⬇️

scientific article published on May 25, 2011

Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control

scientific article published on 3 January 2013

Human lung epithelial cells express a functional cold-sensing TRPM8 variant

scientific article

Improved Cytochrome P450 3A4 Molecular Models Accurately Predict the Phe215 Requirement for Raloxifene Dehydrogenation Selectivity ⬇️

scientific article published on October 19, 2010

Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures

scientific article published on 25 April 2008

Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles

scientific article

Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins

scientific article published on 01 January 2006

Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay

scientific article published on 12 November 2014

Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes

scientific article published on 25 October 2007

Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.

scientific article

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes ⬇️

scientific article published on November 9, 2012

Metabolism and bioactivation of 3-methylindole by human liver microsomes.

scientific article published in January 2007

Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes

scientific article published on 19 March 2013

Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells

scientific article published in March 2003

Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes

scientific article published on January 2006

Molecular mechanisms regulating human CYP4B1 lung-selective expression

scientific article

Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action

scientific article

Potent Mutagenicity of 3-Methylindole Requires Pulmonary Cytochrome P450-Mediated Bioactivation: A Comparison to the Prototype Cigarette Smoke Mutagens B(a)P and NNK ⬇️

scientific article published on August 26, 2010

Quantum mechanically derived AMBER‐compatible heme parameters for various states of the cytochrome P450 catalytic cycle ⬇️

scientific article published on October 14, 2011

Reactive Intermediates Produced from the Metabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes ⬇️

scientific article published on November 6, 2012

Regulation of CYP3A genes by glucocorticoids in human lung cells

scientific article published on 13 August 2013

Respective Roles of CYP2A5 and CYP2F2 in the Bioactivation of 3-Methylindole in Mouse Olfactory Mucosa and Lung: Studies Using Cyp2a5-Null and Cyp2f2-Null Mouse Models ⬇️

scientific article published on January 6, 2012

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase

scientific article

Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene

scientific article published on 28 April 2005

Structural and enzymatic parameters that determine alkyl dehydrogenation/hydroxylation of capsaicinoids by cytochrome p450 enzymes

scientific article published on 7 January 2005

Structure-Activity Relationship of Capsaicin Analogs and Transient Receptor Potential Vanilloid 1-Mediated Human Lung Epithelial Cell Toxicity ⬇️

scientific article published on February 22, 2011

TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells

scientific article published on 24 August 2005

The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme

scientific article

The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract

scientific article published on 16 July 2009

Time-dependent changes in plasma concentrations of 3-methylindole and blood concentrations of 3-methyleneindolenine-adduct in feedlot cattle

scientific article

Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells

scientific article published on 04 June 2007

Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells

scientific article published on March 2007

Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material

scientific article published on 9 December 2011

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme

scientific article published in September 2005

Paulina is supported by:

About Paulina

Help