List of works - Matthew D Scharff

A role for Mlh3 in somatic hypermutation

scientific article published on 27 March 2006

A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation

scientific article

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

scientific article published on 30 April 2020

AID and Apobec3G haphazard deamination and mutational diversity

scientific article

AID and mismatch repair in antibody diversification

scientific article

AIDing antibody diversity by error-prone mismatch repair

scientific article

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

scientific article published in April 2003

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

scientific article (publication date: 14 February 2002)

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

scientific journal article

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation

scientific article published on 01 March 2020

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells

scientific article

Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination

scientific article

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

scientific article

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

scholarly article

Does antisense make sense of AID targeting?

scholarly article

Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation

Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification

scientific journal article

Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.

scientific article published on 05 September 2006

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus

scientific article published on 17 February 2012

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

scholarly article

Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells.

scientific article published on 17 April 2018

Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones

scientific article

IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

scientific article

Identifying protein-protein interactions in somatic hypermutation

scientific article published on 14 February 2005

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

scientific article published on October 2003

Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells

scientific article published on 23 September 2011

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

scientific article

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

scientific article published on 10 June 2013

Methylation protects cytidines from AID-mediated deamination

scientific article published in March 2005

Mismatch-mediated error prone repair at the immunoglobulin genes

scientific article published on 24 October 2011

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro

scientific article published on 17 July 2009

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

scientific journal article

Msh6 protects mature B cells from lymphoma by preserving genomic stability

scientific article

Mutation detection of immunoglobulin V-regions by DHPLC.

scientific article

Mutations in AID and UNG extend the function of AID ⬇️

scientific article published on October 1, 2003

Overlapping hotspots in CDRs are critical sites for V region diversification

scientific article

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

scientific article

Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells

scientific article

Requirement for cyclin D3 in germinal center formation and function.

scientific article

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets

scientific article

Somatic Hypermutation

Somatic hypermutation of the AID transgene in B and non-B cells

scientific article

Targeting AID to the Ig genes

scientific article published on January 2007

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination

scientific article published on 26 March 2012

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

scientific journal article

The biochemistry of somatic hypermutation

scientific article published on January 2008

The generation of antibody diversity through somatic hypermutation and class switch recombination

scientific article

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus

scientific journal article

The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies

scientific article

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

scholarly article

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment

scholarly article

List of works by Matthew D Scharff

A role for Mlh3 in somatic hypermutation

A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

AID and Apobec3G haphazard deamination and mutational diversity

AID and mismatch repair in antibody diversification

AIDing antibody diversity by error-prone mismatch repair

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells

Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

Does antisense make sense of AID targeting?

Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation

Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification

Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells.

Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones

IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

Identifying protein-protein interactions in somatic hypermutation

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

Methylation protects cytidines from AID-mediated deamination

Mismatch-mediated error prone repair at the immunoglobulin genes

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

Msh6 protects mature B cells from lymphoma by preserving genomic stability

Mutation detection of immunoglobulin V-regions by DHPLC.

Mutations in AID and UNG extend the function of AID ⬇️

Overlapping hotspots in CDRs are critical sites for V region diversification

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells

Requirement for cyclin D3 in germinal center formation and function.

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets

Somatic Hypermutation

Somatic hypermutation of the AID transgene in B and non-B cells

Targeting AID to the Ig genes

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

The biochemistry of somatic hypermutation

The generation of antibody diversity through somatic hypermutation and class switch recombination

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus

The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment