List of works - Christof von Kalle

International network of cancer genome projects

scientific article

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

scientific article published in January 2003

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

scientific article

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

scientific article

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

scientific article published on September 2008

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

scientific article

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome

scientific article

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

scientific article (publication date: June 2006)

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

scientific article

An unbiased genome-wide analysis of zinc-finger nuclease specificity

scientific article

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

scientific article

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

scientific article published on 23 March 2009

Effective gene therapy with nonintegrating lentiviral vectors

scientific article

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

scientific article

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

scientific article published on 6 July 2006

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

scientific article

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

scientific article

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

scientific article published in December 2007

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

scientific article published in August 2007

Side effects of retroviral gene transfer into hematopoietic stem cells

scientific article

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

scientific article

Gene therapy: therapeutic gene causing lymphoma

scientific article (publication date: 27 April 2006)

Hot spots of retroviral integration in human CD34+ hematopoietic cells

scientific article

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy

scientific article published on 26 August 2014

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

scientific article published on January 2004

Polyclonal long-term repopulating stem cell clones in a primate model

scientific article published in October 2002

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

scientific article published in August 2007

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

scientific article published on 15 February 2009

BRAF Inhibition in Refractory Hairy-Cell Leukemia

scientific article published on May 24, 2012

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

scientific article published on 14 March 2011

TALEN-based gene correction for epidermolysis bullosa.

scientific article published on 2 April 2013

Stem cell collection and gene transfer in Fanconi anemia

scientific article published on January 2007

Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle

scientific article published on 4 June 2008

Comprehensive genomic access to vector integration in clinical gene therapy

scientific article published on 22 November 2009

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

scientific article

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

scientific article published on 2 June 2005

Bone marrow-derived cells contribute to infarct remodelling

scientific article published on 14 June 2006

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis

scientific article

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing

scientific article published on July 8, 2010

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

scientific article published on 26 January 2006

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

scientific article published on 17 October 2002

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

scientific article published on April 2003

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

scientific article

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

article

A largely random AAV integration profile after LPLD gene therapy

scientific article published on June 16, 2013

List of works by Christof von Kalle

International network of cancer genome projects

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome

Dissecting the genomic complexity underlying medulloblastoma

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

An unbiased genome-wide analysis of zinc-finger nuclease specificity

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

Effective gene therapy with nonintegrating lentiviral vectors

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Side effects of retroviral gene transfer into hematopoietic stem cells

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

Gene therapy: therapeutic gene causing lymphoma

Hot spots of retroviral integration in human CD34+ hematopoietic cells

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

Polyclonal long-term repopulating stem cell clones in a primate model

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

BRAF Inhibition in Refractory Hairy-Cell Leukemia

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

TALEN-based gene correction for epidermolysis bullosa.

Stem cell collection and gene transfer in Fanconi anemia

Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle

Comprehensive genomic access to vector integration in clinical gene therapy

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

Bone marrow-derived cells contribute to infarct remodelling

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

A largely random AAV integration profile after LPLD gene therapy