Search filters

List of works by Christof von Kalle

A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App.

scientific article published on 21 September 2017

A Face-Aging App for Smoking Cessation in a Waiting Room Setting: Pilot Study in an HIV Outpatient Clinic

article

A Face-Aging App for Smoking Cessation in a Waiting Room Triggers Quitting: Pilot Study in an HIV Outpatient Clinic (Preprint)

article

A Face-Aging Smoking Prevention/Cessation Intervention for Nursery School Students in Germany: An Appearance-Focused Interventional Study

article

A Skin Cancer Prevention Facial-Aging Mobile App for Secondary Schools in Brazil: Appearance-Focused Interventional Study

scientific article published on 9 March 2018

A Skin Cancer Prevention Facial-Aging Mobile App for Secondary Schools in Brazil: Appearance-Focused Interventional Study (Preprint)

article

A largely random AAV integration profile after LPLD gene therapy ⬇️

scientific article published on June 16, 2013

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

scientific article published in January 2003

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

scientific article published on 26 January 2006

Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle

scientific article published on 4 June 2008

An unbiased genome-wide analysis of zinc-finger nuclease specificity

scientific article

Analysis of the Clonal Repertoire of Gene-Corrected Cells in Gene Therapy

scientific article published on January 1, 2012

Analyzing the Number of Common Integration Sites of Viral Vectors – New Methods and Computer Programs ⬇️

scientific article published on October 14, 2011

Artificial Intelligence and Its Effect on Dermatologists' Accuracy in Dermoscopic Melanoma Image Classification: Web-Based Survey Study

scientific article published on 11 September 2020

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

scientific article

BRAF Inhibition in Refractory Hairy-Cell Leukemia ⬇️

scientific article published on May 24, 2012

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

scientific article

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites

scientific article

Bone marrow-derived cells contribute to infarct remodelling

scientific article published on 14 June 2006

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy

scientific article published on 26 August 2014

Cell cycle status of CD34(+) hemopoietic stem cells determines lentiviral integration in actively transcribed and development-related genes

scientific article

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

scientific article published on 6 July 2006

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy

scientific article published in June 2012

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

scientific article published on January 2004

Chemovirotherapy of Malignant Melanoma with a Targeted and Armed Oncolytic Measles Virus ⬇️

scientific article published on December 6, 2012

Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

scientific article published on 7 December 2004

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy

scientific article published on 11 April 2011

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

scientific article published on 17 March 2003

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector

scientific article

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

scientific article published on April 2003

Comprehensive genomic access to vector integration in clinical gene therapy

scientific article published on 22 November 2009

Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia

scientific article

Copy number determination of genetically-modified hematopoietic stem cells

scientific article published in January 2009

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

scientific article

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

scientific article

Corrigendum to "Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs".

scientific article published on November 2011

Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".

scientific article published on 3 November 2005

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples

scientific article

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

scientific article

Drug-perturbation-based stratification of blood cancer

scientific article published on 11 December 2017

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates

scientific article published on 12 February 2004

Effective gene therapy with nonintegrating lentiviral vectors

scientific article

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.

scientific article published in May 2003

Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

scientific article published on 21 April 2005

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV

scientific article published on 7 January 2015

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

scientific article published on 27 October 2015

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice

scientific article

Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo

scientific article

Facial-Aging Mobile Apps for Smoking Prevention in Secondary Schools in Brazil: Appearance-Focused Interventional Study

article

Failure of SCID-X1 gene therapy in older patients

scientific article

Fanconi anemia gene editing by the CRISPR/Cas9 system

scientific article

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

scientific article

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

scientific article published in August 2007

Gene Therapy Targeting Hematopoietic Cells: Better Not Leave It to Chance ⬇️

scientific article published on January 1, 2003

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

article

Gene and Cell Therapy in Germany

scientific article published in October 2017

Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis

scientific article published on 30 October 2014

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

scientific article

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

scientific article

Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector

scientific article published on February 2010

Gene therapy: therapeutic gene causing lymphoma

scientific article (publication date: 27 April 2006)

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

scientific article published on 22 July 2015

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model

scientific article

Genome editing technologies: defining a path to clinic

scientific article published on May 2015

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

scientific article published on 12 February 2017

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing ⬇️

scientific article published on July 8, 2010

Genome-wide mapping of foamy virus vector integrations into a human cell line

scientific article published on May 2006

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

scientific article

Granulocyte-macrophage colony-stimulating factor-armed oncolytic measles virus is an effective therapeutic cancer vaccine

scientific article published on July 2013

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation

scientific article published on 9 April 2010

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

scientific article

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

scientific article (publication date: June 2006)

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

scientific article

High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion

scientific article

High-resolution analysis of the human T-cell receptor repertoire

scientific article published in September 2015

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

scientific article published in December 2007

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

scientific article published on April 2015

Hot spots of retroviral integration in human CD34+ hematopoietic cells

scientific article

Identification of NY-BR-1-specific CD4(+) T cell epitopes using HLA-transgenic mice

scientific article

Identity, Potency,In VivoViability, and Scaling Up Production of Lentiviral Vector-Induced Dendritic Cells for Melanoma Immunotherapy ⬇️

scientific article published on February 1, 2012

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

scientific article published on 11 May 2015

Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials

scientific article published on 13 February 2007

In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector

scientific article

Insertion Site Pattern: Global Approach by Linear Amplification-Mediated PCR and Mass Sequencing ⬇️

scientific article published on January 1, 2012

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

scientific article published on 23 August 2011

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

scientific article published on September 2008

Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver

scientific article

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

scientific article

Integration of retroviral vectors ⬇️

scientific article published on September 14, 2012

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

scientific article

Integration-deficient Lentiviral Vectors Expressing Codon-optimized R338L Human FIX Restore Normal Hemostasis in Hemophilia B Mice ⬇️

scientific article published on August 14, 2013

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

scientific article

International network of cancer genome projects

scientific article

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases

scientific article published on 25 May 2016

Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)

scientific article published in Nature

Lenti in red: progress in gene therapy for human hemoglobinopathies

scientific article published on October 2004

Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation

scientific article published on 21 August 2017

Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy

scientific article published in January 2012

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

scientific article

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

scientific article

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

scientific article published on 14 March 2011

Lentiviral vector integration profiles differ in rodent postmitotic tissues

scientific article

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

scientific article published on 17 October 2002

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

scientific article published on 13 January 2013

Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research

scientific article published in May 2006

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors

scientific article

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis

scientific article

Linear amplification mediated PCR--localization of genetic elements and characterization of unknown flanking DNA.

scientific article

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

scientific article published in March 2004

Long-term regulation of genetically modified primary hematopoietic cells in dogs

scientific article

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

article

Mapping the precision of genome editing

scientific article published in February 2015

Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

scientific article published on November 2003

MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism

scientific article

Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells

scientific article published on November 2002

Molekulargenetische Diagnostik - Was wissen die Maschinen? Was wollen wir wissen?

scientific article published on 31 August 2016

Mutations in ROGDI Cause Kohlschütter-Tönz Syndrome

scientific article

Next-generation sequencing of cancer consensus genes in lymphoma

scientific article published on 14 June 2013

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

scientific article

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

scientific article published on 31 January 2017

Outperforming Dermatologist-Level Skin Cancer Classification via Enhanced Training of Deep Neural Networks (Preprint)

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient

scientific article published in September 2013

Patient-Centered Mobile Health Data Management Solution for the German Health Care System (The DataBox Project) (Preprint)

article

Patient-Centered Mobile Health Data Management Solution for the German Health Care System (The DataBox Project).

scientific article published on 11 May 2018

Patient-Centered Mobile Health Data Management Solution for the German Healthcare System: The DataBox Project

article

Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

scientific article

Pharmacologically regulated in vivo selection in a large animal

scientific article published in September 2002

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

scientific article published on 15 February 2009

Polyclonal long-term repopulating stem cell clones in a primate model

scientific article published in October 2002

Precision oncology based on omics data: The NCT Heidelberg experience

scientific article

Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease

scientific article

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome

scientific article

Process Evaluation of a Medical Student-Delivered Smoking Prevention Program for Secondary Schools: Protocol for the Education Against Tobacco Cluster Randomized Trial

scientific article published on 11 April 2019

Real-time definition of non-randomness in the distribution of genomic events

scientific article

Recent Developments and Future Perspectives of Personalized Oncology ⬇️

scientific article published on January 20, 2012

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

scientific article

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells ⬇️

scientific article published on 2 June 2005

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors

scientific article published in June 2014

Retroviral Gene Therapy for X-linked Chronic Granulomatous Disease: Results From Phase I/II Trial ⬇️

scientific article published on August 30, 2011

Retroviral Vectors for Gene Therapy ⬇️

scientific article published on October 1, 2010

Retroviral Vectors: Post Entry Events and Genomic Alterations ⬇️

scientific article published on April 29, 2011

Retrovirally transduced muscle-derived cells contribute to hematopoiesis at very low levels in the nonhuman primate model

scientific article published in December 2003

Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria

scientific article published on December 2013

Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells

scientific article

Shifting cancer care towards Multidisciplinarity: the cancer center certification program of the German cancer society

scientific article published on 14 December 2017

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype

scientific article published on 30 May 2006

Side effects of retroviral gene transfer into hematopoietic stem cells

scientific article

Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review

scholarly article by Titus Josef Brinker et al published 17 October 2018 in Journal of Medical Internet Research

Skin Cancer Classification using Convolutional Neural Networks: Systematic Review (Preprint)

scholarly article published 14 August 2018

So rare we need to hunt for them: reframing the ethical debate on incidental findings

scientific article published on 30 July 2015

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

scientific article

Stable human FIX expression after 0.9G intrauterine gene transfer of self-complementary adeno-associated viral vector 5 and 8 in macaques

scientific article published on 31 May 2011

Stable long-term blood formation by stem cells in murine steady-state hematopoiesis

scientific article published in September 2012

Stem cell collection and gene transfer in Fanconi anemia

scientific article published on January 2007

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

scientific article

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

scientific article

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

scientific article

Systematic comparative study of computational methods for T-cell receptor sequencing data analysis

scientific article

TALEN-based gene correction for epidermolysis bullosa.

scientific article published on 2 April 2013

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

scientific article

Targeted BiTE expression by an oncolytic vector augments therapeutic efficacy against solid tumors

scientific article published on 6 February 2018

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia

scientific article

Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma

scientific article

Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing

article by Titus Josef Brinker et al published 24 October 2018 in Journal of Medical Internet Research

Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing (Preprint)

article

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

scientific article published on 20 July 2015

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

scientific article published on 13 November 2012

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

scientific article published on 23 March 2009

The impact of low-dose busulfan on clonal dynamics in nonhuman primates

scientific article

The influence of low molecular weight heparin medication on plasma DNA in pregnant women

scientific article published on 6 August 2015

The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny

scientific article published in May 2010

Thymus-autonomous T cell development in the absence of progenitor import

scientific article

Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease

scientific article

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

scientific article (publication date: 2016)

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

scientific article

Vector integration and tumorigenesis

scientific article

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

scientific article published in August 2007

Paulina is supported by:

About Paulina

Help