Search filters

List of works by Steven J Shire

2005 AAPS biotechnology conference open forum on aggregation of protein therapeutics - panel discussion June 5-8, 2005 San Francisco, CA

scientific article published on January 2006

A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation

scientific article published on 22 September 2006

A technical feasibility study of dornase alfa delivery with eFlow® vibrating membrane nebulizers: aerosol characteristics and physicochemical stability.

scientific article

A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation

scientific article published on 14 March 2009

Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins

scientific article published on 03 August 2015

Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals.

scientific article published on 14 March 2013

Carboxylate-dependent gelation of a monoclonal antibody

scientific article published in November 2009

Challenges in Determining Intrinsic Viscosity Under Low Ionic Strength Solution Conditions

scientific article

Challenges in the development of high protein concentration formulations

scientific article published on June 2004

Characteristics of rhVEGF release from topical hydrogel formulations

scientific article published on 13 February 2010

Characterization of Particles in Protein Solutions: Reaching the Limits of Current Technologies

scientific article published on October 16, 2010

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

scientific article published on 06 July 2012

Comparative study of analytical techniques for determining protein charge

scientific article published on 24 April 2015

Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A.

scientific article published on 16 September 2014

Concluding summary: proceedings of the AAPS Biotec open forum on "aggregation of protein therapeutics".

scientific article published on January 2006

Dipole-dipole interaction in antibody solutions: correlation with viscosity behavior at high concentration

Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin

scientific article published on 27 July 2017

Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies

scientific article published on 6 April 2011

Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies

scientific article published in December 2010

Formulation and manufacturability of biologics

scientific article published on 31 October 2009

Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties

scientific article

Influence of the cosolute environment on IgG solution structure analyzed by small-angle X-ray scattering.

scientific article published on 03 August 2012

Intermolecular Interactions of IgG1 Monoclonal Antibodies at High Concentrations Characterized by Light Scattering

scientific article published on October 14, 2010

Issues and challenges of subvisible and submicron particulate analysis in protein solutions

scientific article

Leachables from saline-containing IV bags can alter therapeutic protein properties

scientific article published on 30 June 2010

Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations.

scientific article

Monoclonal antibody self-association, cluster formation, and rheology at high concentrations

scientific article published on 17 May 2013

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

scientific article published in September 2005

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity

scientific article

Sexually transmitted infections (STI) and antenatal care (ANC) clinics in Malawi: effective platforms for improving engagement of men at high HIV risk with voluntary medical male circumcision services

scientific article published on 04 January 2021

Small-angle neutron scattering characterization of monoclonal antibody conformations and interactions at high concentrations

scientific article published on August 2013

Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions

scientific article published on 06 October 2015

Specific interactions in high concentration antibody solutions resulting in high viscosity

scientific article published on 01 March 2010

The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies

scientific article published on 24 July 2018

The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

scientific article published on March 19, 2012

The Molecular Interaction Process

scientific article published on 30 October 2019

The effect of cosolutes on the isomerization of aspartic acid residues and conformational stability in a monoclonal antibody

scientific article published on July 2007

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modeling

scientific article published on 25 January 2013

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime

scientific article published on 13 December 2010

Viscosity Analysis of High Concentration Bovine Serum Albumin Aqueous Solutions

scientific article published on April 14, 2011

Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects

scientific article published on November 23, 2011

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

scientific article published on July 3, 2012