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List of works by Anton Middelberg

A Designed Biosurfactant Protein for Switchable Foam Control ⬇️

scientific article published on 01 March 2011

A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines.

scientific article published on 7 June 2011

A new kinetic scheme for lysozyme refolding and aggregation

scientific article published on 01 September 2003

A partially purified outer membrane protein VirB9-1 for low-cost nanovaccines against Anaplasma marginale

scientific article published on 24 November 2016

A simple and low-cost platform technology for producing pexiganan antimicrobial peptide in E. coli.

scientific article

A simplified bioprocess for human alpha-fetoprotein production from inclusion bodies

scientific article published in May 2007

Affinity purification of viral protein having heterogeneous quaternary structure: modeling the impact of soluble aggregates on chromatographic performance.

scientific article

Analysis of monoPEGylated human galectin-2 by small-angle X-ray and neutron scattering: concentration dependence of PEG conformation in the conjugate.

scientific article published on 4 November 2010

Assembly of human papillomavirus type-16 virus-like particles: multifactorial study of assembly and competing aggregation

scientific article published in March 2006

Beyond disease, how biomedical engineering can improve global health

scientific article

Bioengineering virus-like particles as vaccines

scientific article published on 17 December 2013

Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery

scientific article published on 19 August 2019

Biomimetic Silica Nanocapsules for Tunable Sustained Release and Cargo Protection.

scientific article published on 16 May 2017

Biomolecular engineering for recombinant sustainable surfactants

Biomolecular engineering of virus-like particles aided by computational chemistry methods.

scientific article published on 18 September 2015

Bioprocess-centered molecular design (BMD) for the efficient production of an interfacially active peptide

scientific article published in September 2004

Characterization of low-frequency modes in aqueous peptides using far-infrared spectroscopy and molecular dynamics simulation

scientific article published on 4 October 2011

Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses

scientific article published on 19 June 2019

Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation.

scientific article published on 29 April 2014

Co-delivery of antigen and a lipophilic anti-inflammatory drug to cells via a tailorable nanocarrier emulsion.

scientific article published on 22 November 2011

Combined in-fermenter extraction and cross-flow microfiltration for improved inclusion body processing

scientific article published in January 2004

Comparison of histidine-tag capture chemistries for purification following chemical extraction

scientific article

Comparison of positional surfactant isomers for displacement of rubisco protein from the air-water interface.

scientific article published on 27 April 2011

Computational study of elements of stability of a four-helix bundle protein biosurfactant.

scientific article

Continuous chromatographic protein refolding

scientific article published in January 2004

Continuous processing of fusion protein expressed as an Escherichia coli inclusion body.

scientific article published in March 2003

Controlled Generation of Ultrathin-Shell Double Emulsions and Studies on Their Stability

scientific article published on 23 January 2017

Controlled oxidative protein refolding using an ion-exchange column

scientific article published in April 2005

Cooperative tuneable interactions between a designed peptide biosurfactant and positional isomers of SDOBS at the air-water interface.

scientific article published in April 2009

Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity

scientific article published on 24 January 2018

Coupling of chemical extraction and expanded-bed adsorption for simplified inclusion-body processing: optimization using surface plasmon resonance

scientific article

Critical analysis of lysozyme refolding kinetics

scientific article published in May 2002

Design of Modular Peptide Surfactants and Their Surface Activity

scientific article

Design strategies to address the effect of hydrophobic epitope on stability and in vitro assembly of modular virus-like particle

scientific article

Determining the Structure of Interfacial Peptide Films: Comparing Neutron Reflectometry and Molecular Dynamics Simulations

article

Direct Selective Functionalization of Nanometer-Separated Gold Electrodes with DNA Oligonucleotides

Directed disassembly of an interfacial rubisco protein network.

scientific article published on 21 April 2007

Dispersive mixing and intraparticle partitioning of protein in size-exclusion chromatographic refolding

scientific article published on 5 October 2011

Effect of operating variables on the yield of recombinant trypsinogen for a pulse-fed dilution-refolding reactor

scientific article published in February 2002

Effects of fluid-fluid interfacial elasticity on droplet formation in microfluidic devices

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

scientific article published on 22 April 2013

Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing.

scientific article

Electron transfer of plurimodified DNA SAMs

scientific article

Emulsion-templated silica nanocapsules formed using bio-inspired silicification.

scientific article published in October 2014

Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations

scientific article

Estimating the potential refolding yield of recombinant proteins expressed as inclusion bodies

scientific article published in September 2004

Evaluation of baiting fipronil-loaded silica nanocapsules against termite colonies in fields

scientific article published on 10 August 2019

Far-infrared spectroscopy of protein higher-order structures

scientific article published on 01 November 2010

Foaming properties of a peptide designed to form stimuli-responsive interfacial films

scientific article published on 01 November 2006

From Folding to Function: Design of a New Switchable Biosurfactant Protein.

scientific article

Generic technique to generate large branched DNA complexes

scientific article published in March 2006

High-level expression of soluble viral structural protein in Escherichia coli.

scientific article published on 4 February 2008

High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli.

scientific article published on 17 December 2015

Hybrid organic-inorganic nanoparticles: controlled incorporation of gold nanoparticles into virus-like particles and application in surface-enhanced Raman spectroscopy

Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor–Couette shear cell

Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale

scientific article

Impact of Site-Specific Bioconjugation on the Interfacial Activity of a Protein Biosurfactant

scientific article published on 08 October 2019

Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions.

scientific article

Insights into the role of protein molecule size and structure on interfacial properties using designed sequences.

scientific article published on 9 January 2013

Integrated molecular and bioprocess engineering for bacterially produced immunogenic modular virus-like particle vaccine displaying 18 kDa rotavirus antigen

scientific article published on 6 August 2016

Interfacial biomimetic synthesis of silica nanocapsules using a recombinant catalytic modular protein

scientific article published on 2 February 2015

Interfacial engineering for silica nanocapsules.

scientific article published on 7 August 2016

Intrinsic fluorescence as an analytical probe of virus-like particle assembly and maturation

scientific article published on 13 August 2008

Large branched self-assembled DNA complexes

Low-frequency spectroscopic analysis of monomeric and fibrillar lysozyme

scientific article published on 01 March 2011

Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release

scientific article published on 07 August 2013

Magnetic silica spheres with large nanopores for nucleic acid adsorption and cellular uptake

scientific article

Mechanical properties of interfacial films formed by lysozyme self-assembly at the air-water interface

scientific article published in October 2006

Microbial production of virus-like particle vaccine protein at gram-per-litre levels.

scientific article published on 24 August 2010

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants.

scientific article published on 28 December 2013

Microfluidic Elucidation of the Effects of Interfacial Rheology on Droplet Deformation

Microfluidic mass-transfer control for the simple formation of complex multiple emulsions

scientific article published on 01 January 2009

Microfluidic synthesis of multifunctional liposomes for tumour targeting.

scientific article published on 12 September 2016

Mixed system of Eudragit s-100 with a designed amphipathic peptide: control of interfacial elasticity by solution composition

scientific article published on 15 February 2008

Modeling the competition between aggregation and self-assembly during virus-like particle processing.

scientific article

Modular virus-like particles for sublingual vaccination against group A streptococcus.

scientific article

Molecular energetics in the capsomere of virus-like particle revealed by molecular dynamics simulations

scientific article published on 26 April 2013

Molecular insight into conformational transition of amyloid β-peptide 42 inhibited by (-)-epigallocatechin-3-gallate probed by molecular simulations

scientific article published on 23 September 2011

Nanoparticle elasticity regulates phagocytosis and cancer cell uptake

scientific article published on 17 April 2020

Nanoparticle vaccines

scientific article published on 02 December 2013

Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner.

scientific article

Non-chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules.

scientific article published on 20 August 2016

Non-chromatographic preparation of a bacterially produced single-shot modular virus-like particle capsomere vaccine for avian influenza.

scientific article

Operational regimes for a simplified one-step artificial chaperone refolding method

scientific article published in November 2004

Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy.

scientific article

Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery

scientific article

Preparative protein refolding

scientific article

Production of enzymatically active ketosteroid isomerase following insoluble expression in Escherichia coli

scientific article published in November 2006

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: extending the potential of broadly cross-protecting epitopes.

scientific article

Quantitative analysis of virus-like particle size and distribution by field-flow fractionation.

scientific article published in April 2008

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

scientific article published in February 2009

Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering.

scientific article published on 16 March 2008

Rapid response bioprocessing of influenza vaccines

Rapid screening of surfactant and biosurfactant surface cleaning performance.

scientific article published in April 2009

Relation between cell disruption conditions, cell debris particle size, and inclusion body release

scientific article published in October 2004

Reversible active switching of the mechanical properties of a peptide film at a fluid-fluid interface

scientific article published on 21 May 2006

Screening protein refolding using surface plasmon resonance

scientific article published in April 2004

Selective dielectrophoretic manipulation of surface-immobilized DNA molecules

article by W Andr Germishuizen et al published 18 June 2003 in Nanotechnology

Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS).

scientific article published on 17 February 2013

Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle.

scientific article published on 8 July 2013

Single-site Cys-substituting mutation of human lectin galectin-2: modulating solubility in recombinant production, reducing long-term aggregation, and enabling site-specific monoPEGylation.

scientific article

Size analysis of poly(3-hydroxybutyric acid) granules produced in recombinant Escherichia coli

Stabilizing and destabilizing protein surfactant-based foams in the presence of a chemical surfactant: Effect of adsorption kinetics.

scientific article published on 21 September 2015

Stable Ultrathin-Shell Double Emulsions for Controlled Release.

scientific article published on 2 March 2016

Stimuli-responsive peptide nanostructures at the fluid-fluid interface

scientific article published on 01 January 2013

Structural-based designed modular capsomere comprising HA1 for low-cost poultry influenza vaccination

scientific article

Subcellular compartment targeting of layered double hydroxide nanoparticles

scientific article

Sustained release of fipronil insecticide in vitro and in vivo from biocompatible silica nanocapsules.

scientific article published on 16 December 2014

Synergetic Combinations of Dual-Targeting Ligands for Enhanced In Vitro and In Vivo Tumor Targeting

scientific article published on 23 May 2018

Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle.

scientific article published on 17 September 2015

Synthetic biology for bioengineering virus-like particle vaccines

scientific article published on 31 December 2018

Terahertz and conventional analysis of virus-like particle vaccines

article published in 2009

Terahertz and far infrared spectroscopy of alanine-rich peptides having variable ellipticity

scientific article published on December 2010

Terahertz spectroscopic differentiation of microstructures in protein gels

scientific article published in July 2009

The Impact of Bioconjugation on the Interfacial Activity of a Protein Biosurfactant

article published in 2019

The construction, fouling and enzymatic cleaning of a textile dye surface

scientific article published on 17 July 2010

The influence of molecular variation on protein interactions ⬇️

scientific article published on December 5, 2003

The likelihood of aggregation during protein renaturation can be assessed using the second virial coefficient

scientific article published in April 2003

The refolding of different alpha-fetoprotein variants

scientific article published in August 2006

To our readers: Important notice

scientific article published on 09 July 2020

Towards the preparative and large-scale precision manufacture of virus-like particles

scientific article

Tuneable control of interfacial rheology and emulsion coalescence

scientific article published on 01 March 2009

Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting

scientific article published on 28 February 2018

Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres.

scientific article published on 22 July 2009

Virus-Like Particle Bioprocessing

Virus-like particle formulation optimization by miniaturized high-throughput screening.

scientific article published on 30 April 2013

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