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List of works by Alexandra Hockla

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

scientific article published in Journal of Biological Chemistry

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis

scientific article

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

scientific article

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

scientific article published on 30 January 2019

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

scientific article published in Nature Communications

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates

scientific article

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

scientific article

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) ⬇️

scientific article published on November 20, 2012

PRSS3/Mesotrypsin Is a Therapeutic Target for Metastatic Prostate Cancer ⬇️

scientific article published on December 1, 2012

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

scientific article published in Scientific Reports

Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

scientific article published on 13 March 2018

Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

scientific article

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

scientific article published on 30 September 2015

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

scientific article

Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

scientific article published on 14 September 2020

The P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity

scientific article

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

scientific article

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