List of works - Christian Klein

Antiviral strategies. Dengue and West Nile Virus

scientific article published on January 2010

Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

article

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

scientific article published on 25 October 2011

Backbone modifications in peptidic inhibitors of flaviviral proteases

scientific article published on 28 May 2019

Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases

scientific article

Biochemistry and medicinal chemistry of the dengue virus protease

scientific article published on 30 September 2014

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

scientific article (publication date: 5 May 2017)

C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease

scientific article

Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity

scientific article published on 24 November 2012

Computational Methods Facilitate the Assignment of Protein Functions

scientific article published on 01 November 2001

Correction to Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes

scientific article published on 01 September 2020

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

scientific article

Development and evaluation of a FACS-based medium-throughput assay for HCV entry inhibitors

scientific article

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

scientific article published on 12 November 2015

Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease

scientific article published on 14 February 2019

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality

scientific article

Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids

scientific article published on 15 July 2015

Fluorimetric and HPLC-based dengue virus protease assays using a FRET substrate

scientific article published on January 2013

Frontiers in Medicinal Chemistry 2009--a summary of the meeting at Heidelberg University

scientific article published in August 2009

Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors

scientific article published on 21 September 2016

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimization

scientific article

Lipophilicity and membrane interactions of cationic-amphiphilic compounds: syntheses and structure-property relationships

scientific article

Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening

scientific article published on 01 April 2020

Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assays

scientific article published in June 2005

Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1.

scientific article

Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions

scientific article published in January 2006

Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective

N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b

scientific article published in 2016

Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands

Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage

scientific article published on 30 March 2020

On chance discovery in rational drug design. Aspergillus fumigatus and angiogenesis

scientific article published in January 2007

Optimization of assay conditions for dengue virus protease: effect of various polyols and nonionic detergents.

scientific article published on 2 September 2009

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

scientific article published on 14 December 2016

Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes

scientific article published on 24 December 2019

Pharmacological activity and membrane interactions of antiarrhythmics: 4D-QSAR/QSPR analysis

scientific article published in February 1998

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors

scientific article published on 14 September 2015

Phenylglycine racemization in Fmoc-based solid-phase peptide synthesis: Stereochemical stability is achieved by choice of reaction conditions

Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methods.

scientific article

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments

scientific article

Protein-dynamics of the putative HCV receptor CD81 large extracellular loop

scientific article published on April 2004

Protonation states of methionine aminopeptidase and their relevance for inhibitor binding and catalytic activity

scientific article published on 26 September 2003

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

scientific article published on 26 February 2012

S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors

scientific article

Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets

scientific article

Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

scientific article

Solid Phase Synthesis of C-Terminal Boronic Acid Peptides

scientific article published on 22 April 2016

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

scientific article (publication date: June 2017)

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity

scientific article

Structural modifications of salicylates: inhibitors of human CD81-receptor HCV-E2 interaction

scientific article

Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA.

scientific article published on 5 August 2010

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

scientific article published on 27 May 2010

Surprisingly stable helical conformations in alpha/beta-peptides by incorporation of cis-beta-aminocyclopropane carboxylic acids

scientific article

Syntheses and Biological Properties of Brefeldin Analogues

article published in 2010

Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

scientific article published on 18 May 2011

Synthesis and biological properties of novel brefeldin A analogues

scientific article published on 8 July 2013

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

scientific article published on March 2005

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

scientific article

Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase).

scientific article

Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors

scientific article published on 08 May 2019

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents

scientific article published on 21 February 2006

Synthesis, pharmacological and biophysical characterization, and membrane-interaction QSAR analysis of cationic amphiphilic model compounds

scientific article published in September 1999

The Medicinal Chemistry of Dengue Virus

scientific article

The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography

scientific article published in August 2008

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture

scientific article published on 22 October 2013

Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids

scientific article published on 23 April 2019

List of works by Christian Klein

Antiviral strategies. Dengue and West Nile Virus

Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

Backbone modifications in peptidic inhibitors of flaviviral proteases

Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases

Biochemistry and medicinal chemistry of the dengue virus protease

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease

Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity

Computational Methods Facilitate the Assignment of Protein Functions

Correction to Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

Development and evaluation of a FACS-based medium-throughput assay for HCV entry inhibitors

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality

Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids

Fluorimetric and HPLC-based dengue virus protease assays using a FRET substrate

Frontiers in Medicinal Chemistry 2009--a summary of the meeting at Heidelberg University

Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimization

Lipophilicity and membrane interactions of cationic-amphiphilic compounds: syntheses and structure-property relationships

Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening

Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assays

Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1.

Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions

Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective

N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b

Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands

Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage

On chance discovery in rational drug design. Aspergillus fumigatus and angiogenesis

Optimization of assay conditions for dengue virus protease: effect of various polyols and nonionic detergents.

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes

Pharmacological activity and membrane interactions of antiarrhythmics: 4D-QSAR/QSPR analysis

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors

Phenylglycine racemization in Fmoc-based solid-phase peptide synthesis: Stereochemical stability is achieved by choice of reaction conditions

Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methods.

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments

Protein-dynamics of the putative HCV receptor CD81 large extracellular loop

Protonation states of methionine aminopeptidase and their relevance for inhibitor binding and catalytic activity

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors

Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets

Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

Solid Phase Synthesis of C-Terminal Boronic Acid Peptides

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity

Structural modifications of salicylates: inhibitors of human CD81-receptor HCV-E2 interaction

Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA.

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

Surprisingly stable helical conformations in alpha/beta-peptides by incorporation of cis-beta-aminocyclopropane carboxylic acids

Syntheses and Biological Properties of Brefeldin Analogues

Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

Synthesis and biological properties of novel brefeldin A analogues

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase).

Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents

Synthesis, pharmacological and biophysical characterization, and membrane-interaction QSAR analysis of cationic amphiphilic model compounds

The Medicinal Chemistry of Dengue Virus

The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture

Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids