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List of works by Dolores D. Mruk

A local autocrine axis in the testes that regulates spermatogenesis

scientific article

A male contraceptive targeting germ cell adhesion

scientific article

A peptide derived from laminin-γ3 reversibly impairs spermatogenesis in rats

scientific article published on January 2012

A study to assess the assembly of a functional blood-testis barrier in developing rat testes ⬇️

scientific article published on July 1, 2011

AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data

scientific article

AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function

scientific article published on 10 December 2015

Actin binding proteins and spermiogenesis: Some unexpected findings

scientific article published on April 2011

Actin binding proteins in blood-testis barrier function

scientific article

Actin binding proteins, spermatid transport and spermiation

scientific article

Actin cross-linking protein palladin and spermatogenesis

scientific article published on January 2013

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis ⬇️

scientific article published on April 1, 2011

Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis

scientific article

Adherens junction dynamics in the testis and spermatogenesis

scientific article

Adhering Junction Dynamics in the Testis Are Regulated by an Interplay of β1-Integrin and Focal Adhesion Complex-Associated Proteins ⬇️

scientific article published on May 1, 2003

Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation

scientific article

Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP)

scientific article published on April 2013

Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3

scientific journal article

Adjudin targeting rabbit germ cell adhesion as a male contraceptive: a pharmacokinetics study

scientific article

Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes

scientific article

Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo

scientific article published on 14 August 2010

Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions

scientific article

Alpha2-macroglobulin expression in the liver in response to inflammation is mediated by the testis.

scientific article published in June 2005

An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis

scientific journal article

An in vitro system to study Sertoli cell blood-testis barrier dynamics

scientific article published on January 2011

An in vivo study on adjudin and blood-testis barrier dynamics

scientific article published on 02 July 2009

An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective

scientific article published on September 2009

An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model

scientific article published on 12 February 2009

Anchoring junctions as drug targets: role in contraceptive development

scientific article

Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis

scientific article published on 11 December 2016

Antioxidant superoxide dismutase - a review: its function, regulation in the testis, and role in male fertility

scientific article

Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis

scientific article

Biology of the Sertoli Cell in the Fetal, Pubertal, and Adult Mammalian Testis

scientific article published on January 2016

Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells

scientific article

Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway

scientific article published on 23 December 2004

Breast cancer resistance protein (Bcrp) and the testis--an unexpected turn of events

scientific article published on 13 May 2013

Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis

scientific journal article

C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics

scientific article

C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes

scholarly article

Cadmium-induced testicular injury

scientific article

Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development

scientific article

Cell polarity and cytoskeletons-Lesson from the testis.

scientific article

Cell polarity and planar cell polarity (PCP) in spermatogenesis.

scientific article

Cell polarity proteins and spermatogenesis.

scientific article

Cell-cell interactions at the ectoplasmic specialization in the testis

scientific article

Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes

scientific journal article

Cell–Cell Interactions, Cell Polarity, and the Blood–Testis Barrier

Claudin and occludin expression and function in the seminiferous epithelium

scientific article

Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics

scientific journal article

Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly

scientific article

Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption

scientific article published on 17 December 2015

Coordinating cellular events during spermatogenesis: a biochemical model

scientific article

Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface

scientific article

Cross-talk between tight and anchoring junctions-lesson from the testis

scientific article

Crosstalk between Rab GTPases and cell junctions

scientific article

Crosstalk between desmoglein-2/desmocollin-2/Src kinase and coxsackie and adenovirus receptor/ZO-1 protein complexes, regulates blood-testis barrier dynamics

scientific article

Cytokines and junction restructuring during spermatogenesis--a lesson to learn from the testis

scientific article

Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation

scientific article published on 03 August 2009

Cytokines, polarity proteins, and endosomal protein trafficking and signaling-the sertoli cell blood-testis barrier system in vitro as a study model

scientific article

Cytoskeletal dynamics and spermatogenesis

scientific article

Delivering non-hormonal contraceptives to men: advances and obstacles

scientific article

Desmosomes in the testis: Moving into an unchartered territory ⬇️

scientific article published on January 1, 2011

Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study

scientific article

Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier

scientific article published on August 2010

Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion

scientific journal article

Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis

scientific article

Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics?

scientific article

Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier

scientific article published on 29 August 2009

Drug transporters and blood--testis barrier function

scientific article

Drug transporters in spermatogenesis: A re-evaluation of recent data on P-glycoprotein

scientific article

Drug transporters, the blood-testis barrier, and spermatogenesis

scientific article

Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes

scientific article

Ectoplasmic specialization: a friend or a foe of spermatogenesis?

scientific article

Effective Delivery of Male Contraceptives Behind the Blood-Testis Barrier (BTB) - Lesson from Adjudin

scientific article published on 12 January 2016

Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal

scientific article published on 30 September 2015

Emerging role for drug transporters at the blood-testis barrier

scientific article

Enhanced chemiluminescence (ECL) for routine immunoblotting: An inexpensive alternative to commercially available kits

scientific article

Environmental contaminants: Is male reproductive health at risk?

scientific article published on October 2011

Environmental toxicants and male reproductive function ⬇️

scientific article published on January 1, 2011

Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins

scientific article

Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium

scientific article published on 17 March 2009

Erratum: Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2.

scientific article published on 26 July 2017

F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin

scientific article published on 11 February 2019

F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis.

scientific article published on 07 September 2016

Fer Kinase/FerT and Adherens Junction Dynamics in the Testis: An In Vitro and In Vivo Study1 ⬇️

scientific article published on April 16, 2003

Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis

scientific journal article

Filamin A: A regulator of blood-testis barrier assembly during post-natal development

scientific article

Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis

scientific article published on April 2013

Focal adhesion kinase is a blood-testis barrier regulator

scholarly article

Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis

scientific article published on 21 June 2013

Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat

scientific journal article

Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity

scientific article published on 22 April 2015

Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis

scientific article published on 04 May 2016

Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis

scientific article

Gap Junctions and Blood-Tissue Barriers

Gap junctions and blood-tissue barriers

scientific article

Germ cell transport across the seminiferous epithelium during spermatogenesis

scientific article

Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells

scientific journal article

Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells.

scientific article published on 2 October 2015

In Vitro Techniques

In search of suitable in vitro models to study germ cell movement across the blood-testis barrier

scientific article published on January 2012

Indazole carboxylic acids in male contraception

scientific article

Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis

scientific article

Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood-testis-barrier-hemidesmosome functional axis in the testis

scientific article published on July 2011

Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis

scientific article published on 11 August 2013

Intercellular adhesion molecule-1 is a regulator of blood-testis barrier function

scientific journal article

Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat

scientific article published on 2 January 2013

Intercellular adhesion molecules (ICAMs) and spermatogenesis

scientific article

Interleukin 1 alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat

scientific journal article

Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication

scientific article published on 12 February 2016

Interleukin‐lo is a regulator of the blood‐testis barrier ⬇️

scientific article published on December 29, 2010

Interviews with andrologists (part 1). Interview by Katja Wolski

scientific article published on 04 October 2006

Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?

scientific journal article

Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?

scientific article

Junction restructuring and spermatogenesis: the biology, regulation, and implication in male contraceptive development

scientific article published on January 2008

Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with α-catenin at the blood-testis barrier

scientific article published on April 2017

MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis

scientific article published on 15 April 2013

Male contraception: Where do we go from here?

scientific article

Male contraceptive Adjudin is a potential anti-cancer drug

scientific article

Mechanistic Insights into PFOS-Mediated Sertoli Cell Injury

scholarly article by Baiping Mao et al published September 2018 in Trends in Molecular Medicine

Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis

scientific journal article

Mitogen-activated protein kinases in male reproductive function

scientific article

Modulating the Blood-Testis Barrier Towards Increasing Drug Delivery

scientific article published on 10 August 2020

Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay.

scientific article published in January 2018

Myotubularin phosphoinositide phosphatases, protein phosphatases, and kinases: their roles in junction dynamics and spermatogenesis

scientific article

N-wasp is required for structural integrity of the blood-testis barrier

scientific article

New frontiers in nonhormonal male contraception

scientific article

New perspectives in non-hormonal male contraception

scientific article

Nonreceptor Protein Kinases c-Src, c-Yes, and FAK Are Biomarkers for Male Contraceptive Research

P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).

scientific article published on 21 November 2011

Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes

scientific journal article

Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis

scientific journal article

Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study

scientific article published on 04 December 2013

Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2

scientific article

Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats

scientific article published on 18 March 2016

Polarity Protein Complex Scribble/Lgl/Dlg And Epithelial Cell Barriers

article

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers

scientific article

RAB13 participates in ectoplasmic specialization dynamics in the rat testis

scientific article published on 10 December 2008

RAI14 (retinoic acid induced protein 14) is an F-actin regulator: Lesson from the testis

scientific article published on April 2013

Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis

scientific article published on 09 May 2007

Rab8B GTPase and junction dynamics in the testis

scientific article (publication date: April 2003)

Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*.

scientific article

Rat and mouse testicular testin is different from the human tumor suppressor gene TESTIN (Tes): Authors' response to the letter of Dr. S. Kapoor

scientific article published on October 2012

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons

scientific article published in January 2018

Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study

scientific journal article

Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: an in vivo study using an

scientific article published on 09 December 2004

Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process

scientific article published on 23 January 2013

Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.

scientific article

Regulation of blood-testis barrier dynamics by TGF-beta3 is a Cdc42-dependent protein trafficking event

scientific article

Regulation of blood-testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events.

scientific article published on April 2011

Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): an unexpected turn of events

scientific article

Regulation of blood-testis barrier dynamics: an in vivo study

scientific article

Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines

scientific article

Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes

scientific journal article

Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis

scientific article

Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide

scientific article

Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: new insights and advances

scientific article

Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3.

scientific article

Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.

scientific article

Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor ⬇️

scientific article published on August 8, 2012

Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant

scientific article published on 17 November 2017

Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43.

scientific article published on 20 July 2016

Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis

scientific journal article

Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network

scientific article published on 3 January 2013

Role of P-Glycoprotein at the Blood-Testis Barrier on Adjudin Distribution in the Testis

Role of P-glycoprotein at the blood-testis barrier on adjudin distribution in the testis: a revisit of recent data

scientific article

Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis

scientific article

Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis.

scientific article

Sertoli cell tight junction dynamics: their regulation during spermatogenesis

scientific article

Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight

scientific article

Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis

scientific article

Sertoli-germ cell junctions in the testis: a review of recent data

scientific article

Sertolin mediates blood-testis barrier restructuring

scientific article published on 27 January 2014

Signalling pathways regulating the blood-testis barrier

scientific article published on 20 December 2012

Sphingomyelin synthases and testicular function

scientific article published on 01 September 2008

TGF-beta3 and TNFalpha perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: a new concept of BTB regulation during spermatogenesis

scientific article published on 07 December 2008

TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study

scientific article published in April 2003

Targeted and reversible disruption of the blood-testis barrier by an FSH mutant-occludin peptide conjugate

scientific article

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

scientific article

Testicular cell junction: a novel target for male contraception

scientific article

Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis ⬇️

scientific article published on April 1, 2011

Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization

scientific article published on 24 January 2020

The Mammalian Blood-Testis Barrier: Its Biology and Regulation

scientific article

The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis

scientific article

The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin

scientific article published on 28 June 2006

The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology

scientific article published on 18 August 2015

The apical ES-BTB-BM functional axis is an emerging target for toxicant-induced infertility

scientific article published on 02 May 2013

The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception

scientific article

The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics ⬇️

scientific article published on 09 July 2011

The biology of spermatogenesis: the past, present and future

scientific article

The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium

scientific article

The blood-testis barrier and its implications for male contraception

scientific article

The myotubularin family of lipid phosphatases in disease and in spermatogenesis

scientific article

The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes ⬇️

scientific article published on January 1, 2011

Tight junctions in the testis: new perspectives.

scientific article published on May 2010

Transport of germ cells across the seminiferous epithelium during spermatogenesis-the involvement of both actin- and microtubule-based cytoskeletons

scientific article published on 28 November 2016

Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes.

scientific article

Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton

scientific article

Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model

scientific article

Why do we need male contraceptives?

scientific article published on 25 July 2013

Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis

scientific article published on March 2004

c-Src and c-Yes are Two Unlikely Partners of Spermatogenesis and their Roles in Blood-Testis Barrier Dynamics

article

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution

scientific article published on 20 November 2012

c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes

scientific article

mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model

scientific article published on 21 May 2019

p-FAK-Tyr(397) regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization

scientific article

rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment

scientific article

rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9

scientific journal article

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