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List of works by Albert K Groen

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

scientific article

A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice ⬇️

scientific article published on June 30, 2011

A computational model for the analysis of lipoprotein distributions in the mouse: translating FPLC profiles to lipoprotein metabolism

scientific article (publication date: May 2014)

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

scientific article

A role of the bile salt receptor FXR in atherosclerosis

scientific article published on August 2010

A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation

scientific article published on 4 December 2014

AAV8-mediated gene transfer of microRNA-132 improves beta-cell function in mice fed a high fat diet

article

ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

scientific article published on 18 July 2017

Accelerated lipid absorption in mice overexpressing intestinal SR-BI.

scientific article published on 18 January 2006

Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol

scientific article published on 05 May 2009

Acute intake of plant stanol esters induces changes in lipid and lipoprotein metabolism-related gene expression in the liver and intestines of mice

scientific article published on May 2015

Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice

scientific article (publication date: 2 August 2002)

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.

scientific article published on May 2003

An evaluation of the therapeutic potential of fecal microbiota transplantation to treat infectious and metabolic diseases.

scientific article

An unexpected role for bile acid synthesis in adaptation to low temperature

scientific article published on 01 July 2017

Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion

scientific article

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

scientific article

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency

scientific article published on 10 February 2008

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

scientific article published on 12 June 2006

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

scientific article published in January 2002

Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation

scientific article published on 12 March 2020

Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis

scientific article published on 26 October 2017

Beyond intestinal soap--bile acids in metabolic control.

scientific article published on 13 May 2014

Bile Acid Look-Alike Controls Life Span in C. elegans ⬇️

scientific article published on August 6, 2013

Bile Acids and Cholestasis ⬇️

scientific article published on December 21, 2012

Bile acid sequestrants: more than simple resins

scientific article published on February 2012

Bile acid sequestration normalizes plasma cholesterol and reduces atherosclerosis in hypercholesterolemic mice. No additional effect of physical activity

scientific article published on 26 February 2013

Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

scientific article (publication date: 2011)

Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice

scientific article published in June 2005

Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor- and liver X receptor alpha-controlled metabolic pathways in mice.

scientific article published in March 2010

Bile salts in control of lipid metabolism

scientific article published on 30 March 2016

Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients.

scientific article published on 23 July 2016

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

scientific article published on 26 September 2015

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

scientific article published on 3 November 2017

Butyrate via the gut-brain neuronal circuit reduces appetite and activates brown adipose tissue

scientific article

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

scientific journal article

Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1 ⬇️

scientific article published on December 1, 2010

Chipping away at gallstones

scientific article published in July 2008

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet

scientific article

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha

scientific article published on 04 November 2006

Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice.

scientific article published on 12 December 2017

Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance

scientific article published on 31 May 2012

Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice

scientific article published on 25 February 2010

Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development

scientific article published on 07 October 2019

Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats

scientific article published on 13 October 2017

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

scientific article

Correlation of plasma metabolites with glucose and lipid fluxes in human insulin resistance

scientific article published on 07 February 2020

Cross-talk between liver and intestine in control of cholesterol and energy homeostasis

scientific article published on 18 February 2014

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.

scientific article published on 28 April 2016

Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes

scientific article published on 30 June 2016

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

article

Developments in intestinal cholesterol transport and triglyceride absorption

scientific article published on 23 March 2017

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

scientific article published on 20 March 2019

Dietary plant sterols accumulate in the brain

scientific article published on 19 April 2006

Differential DNA methylation in familial hypercholesterolemia

scientific article published on 20 October 2020

Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.

scientific article published in January 2005

Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice

scientific article published on 20 June 2007

Domain intelligible models

scientific article published on 05 July 2018

Donor Fecal Microbiota Transplantation Alters Gut Microbiota and Metabolites in Obese Individuals With Steatohepatitis

scientific article published on 07 October 2020

Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

scientific article published on 30 May 2019

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

scientific article published on January 2010

Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

scientific article published on 18 April 2018

Effect of Oral Insulin on the Severity and Recovery of Methotrexate-Induced Gastrointestinal Mucositis in the Rat

scientific article published on 01 February 2017

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

scientific article

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

scientific article published on 01 August 2016

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial.

scientific article published in July 2016

Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice

scientific article published on 19 July 2019

Emerging roles of the intestine in control of cholesterol metabolism.

scientific article published on October 2006

Evaluating computational models of cholesterol metabolism

scientific article published on 02 July 2015

Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia

scientific article published on 21 July 2006

Exercise enhances whole-body cholesterol turnover in mice

scientific article published in August 2010

Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice

scientific article published on 24 July 2010

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements

scientific article published on 28 June 2019

FXR: the key to benefits in bariatric surgery?

scientific article

Farnesoid X receptor and bile acids regulate vitamin A storage

scientific article published on 20 December 2019

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies ⬇️

scientific article published on May 22, 2013

Fecal Bile Salts and the Development of Necrotizing Enterocolitis in Preterm Infants

scientific article

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice

scientific article

Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol

scientific article published in January 2008

GUT MICROBIOTA AND THE GUT-BRAIN AXIS: NEW INSIGHTS IN THE PATHOPHYSIOLOGY OF METABOLIC SYNDROME.

scientific article published on 27 May 2017

Genetic background of cholesterol gallstone disease

scientific article

Glucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoids

scientific article

Glycosphingolipids and insulin resistance

scientific article published on January 2011

Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives.

scientific article published on 20 April 2018

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids.

scientific article

Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT

article

Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice

scientific article

Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases

scientific article

Hepatocytes contribute to residual glucose production in a mouse model for glycogen storage disease type Ia.

scientific article published on 20 July 2017

High fat feeding induces hepatic fatty acid elongation in mice

scientific article

Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity

scientific article

Human microbiome as therapeutic intervention target to reduce cardiovascular disease risk

scientific article published on 26 September 2016

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.

scientific article

Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition

scientific article

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

scientific article published on 9 August 2013

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

scientific article published on 18 August 2020

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

scientific article published in October 2017

In vivo and in silico dynamics of the development of Metabolic Syndrome.

scientific article

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1 ⬇️

scientific article published on May 6, 2013

Increased expression of key SARS-CoV-2 entry points in multiple tissues in individuals with NAFLD

scientific article published on 15 December 2020

Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice.

scientific article published in January 2005

Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

scientific article published on 8 July 2002

Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome

scientific article published on 08 September 2020

Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice

scientific article published on 18 February 2010

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells

scientific article

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance

scientific article published on 21 June 2016

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

scientific article published on 16 March 2006

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

scientific article published on 5 January 2017

Intestinal Ralstonia pickettii augments glucose intolerance in obesity

scientific article

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

scientific article

Lactate increases hepatic secretion of VLDL-triglycerides in humans

scientific article published on 14 March 2013

Laxative Treatment With Polyethylene Glycol Does Not Affect Lipid Absorption in Rats ⬇️

scientific article published on October 1, 2012

Laxative treatment with polyethylene glycol decreases microbial primary bile salt dehydroxylation and lipid metabolism in the intestine of rats

scientific article published on 18 July 2013

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.

scientific article published on 10 March 2018

Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.

scientific article published on 18 November 2015

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

article

Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.

scientific article

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1.

scientific article published on 22 October 2014

Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation

scientific article

Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men.

scientific article published on 16 October 2017

Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction.

scientific article published on 13 June 2016

Maternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring

scientific article

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

scientific article published on 17 February 2014

Micellar lipid composition profoundly affects LXR-dependent cholesterol transport across CaCo2 cells.

scientific article published on 20 March 2009

Microbiome and Cardiovascular Disease

scientific article published on 18 March 2020

Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

scientific article published on 01 March 2020

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

scientific article

Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy.

scientific article published on 28 September 2017

Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity

scientific article

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice.

scientific article

Oral vancomycin treatment does not alter markers of postprandial inflammation in lean and obese subjects

scientific article published on 01 August 2019

Parameter trajectory analysis to identify treatment effects of pharmacological interventions

scientific article (publication date: 2013)

Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

scientific article published on 14 July 2020

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

scientific article published on 13 May 2009

Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol ⬇️

scientific article published on 03 March 2012

Plasma plant sterols serve as poor markers of cholesterol absorption in man

scientific article published on 25 November 2012

Predictive value of targeted proteomics for coronary plaque morphology in patients with suspected coronary artery disease

scholarly article by Michiel J Bom et al published January 2019 in EBioMedicine

Prednisolone increases enterohepatic cycling of bile acids by induction of Asbt and promotes reverse cholesterol transport

article by Carolien Out et al published August 2014 in Journal of Hepatology

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

scientific article published on 30 September 2016

Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1

scientific article

Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

scientific article

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia.

scientific article published on 18 June 2009

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

scientific article

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

scientific article

Regulation of direct transintestinal cholesterol excretion in mice

scientific article published on 29 May 2008

Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

scientific article published in June 2003

Reply to Letter to the Editor HEP-20-0593

scientific article published on 25 April 2020

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia

scientific article published on 28 October 2016

Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion

scientific article published on 12 May 2011

Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction

scientific article published on 9 February 2017

Role the TICE?: advancing the concept of transintestinal cholesterol excretion

scientific article published in July 2013

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet

scientific article published on 01 March 2019

Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism.

scientific article published on 9 November 2017

Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice ⬇️

scientific article published on May 14, 2013

Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

scientific article

Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

scientific article

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype

scientific article published on 25 August 2014

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

scientific article

Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes

scientific article published in January 2007

Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes

scientific article published on June 2007

The TICE Pathway: Mechanisms and Lipid-Lowering Therapies

The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

scientific article

The ins and outs of reverse cholesterol transport

scientific article published on January 2004

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design

scientific article published on 02 April 2010

The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.

scientific article published on June 2006

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

scientific article

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

scientific article published on 16 April 2003

The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome.

scientific article

The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux

scientific article published on 31 August 2007

Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice

scientific article

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.

scientific article published on 16 July 2012

Transhepatic bile acid kinetics in pigs and humans

scientific article

Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion

scientific article

Transintestinal and Biliary Cholesterol Secretion Both Contribute to Macrophage Reverse Cholesterol Transport in Rats-Brief Report

scientific article published on 23 February 2017

Transintestinal cholesterol excretion in humans.

scientific article published on 16 November 2017

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

scientific article published on 3 August 2011

Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose-response effects on glucose metabolism in human subjects with metabolic syndrome

scientific article published on 27 March 2020

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

scientific article published in November 2002

Tumor Necrosis Factor-Alpha Inhibitor Etanercept Does Not Alter Methotrexate-Induced Gastrointestinal Mucositis in Rats

scientific article published on 01 August 2017

Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling

scientific article published on 4 March 2010

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

scientific article

Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice

scientific article published on 12 July 2011

Weight Gain after Fecal Microbiota Transplantation in a Patient with Recurrent Underweight following Clinical Recovery from Anorexia Nervosa

scientific article published on 09 January 2019

Whole-Body Vibration Partially Reverses Aging-Induced Increases in Visceral Adiposity and Hepatic Lipid Storage in Mice

scientific article published on 17 February 2016

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences ⬇️

scientific article published on June 20, 2013

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