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List of works by Christian Haass

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

scientific article published on 15 June 2006

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

scientific article

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

scientific article

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

scientific article

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

scientific article

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

scientific article published on October 1999

A non-amyloidogenic function of BACE-2 in the secretory pathway

scientific article

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

scientific article

A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.

scientific article

A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques

scientific article

A protein quality control pathway regulated by linear ubiquitination

scientific article published on 18 March 2019

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

scientific article

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

scientific article

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

scientific article

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

scientific article published on November 1993

Active gamma-secretase complexes contain only one of each component

scientific article

Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

scientific article published on 20 December 2019

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice

scientific article published on 26 July 2006

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study

scientific article published on 17 March 2004

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

scientific article

Alzheimer's Disease Associated Presenilin-1 Holoprotein and Its 18−20 kDa C-Terminal Fragment Are Death Substrates for Proteases of the Caspase Family ⬇️

scientific article published on February 24, 1998

Alzheimer's disease. A technical KO of amyloid-beta peptide

scientific article published in January 1998

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

scientific article published on May 2004

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

scientific article

Amyloid beta-peptide is produced by cultured cells during normal metabolism

scientific article published on September 1992

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

scientific article published on April 2006

Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content

scientific article published in August 2007

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

scientific article published on 12 December 2005

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease

scientific article published on 6 January 2011

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

scientific article

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

scientific article

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

scientific article published on 30 August 2017

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

scientific article

Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins

scientific article published on 28 March 2017

Apical Sorting of β-Secretase Limits Amyloid β-Peptide Production ⬇️

scientific article published on December 6, 2001

Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner

scientific article published on 30 September 2005

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

scientific article

Assembly, trafficking and function of gamma-secretase

scientific article

Asymmetry of fibrillar plaque burden in amyloid mouse models

scientific article published on 15 May 2020

Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds ⬇️

scientific article published on February 25, 2011

Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

scientific article published on 7 June 2024

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice

scientific article published on 29 February 2016

BACE1 Dependent Neuregulin Processing: Review ⬇️

scientific article published on February 1, 2012

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

scientific article published on 21 June 2013

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

scientific article published on 2 November 2011

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

scientific article

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

scientific article published on 17 October 2013

Boxing-acute complications and late sequelae: from concussion to dementia

scientific article

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

scientific article

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

scholarly article by Marc Suárez-Calvet et al published December 2018 in EMBO Molecular Medicine

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling ⬇️

scientific article published on May 11, 1998

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

scientific article published on 25 June 2012

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

scientific article

Cellular functions of gamma-secretase-related proteins

scientific article

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

scientific article

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

scientific article published on 18 September 2008

Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

scientific article published on 24 September 2013

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease

scientific article published on 18 June 2013

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

scientific article published in September 2008

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

scientific article published on 21 June 2004

Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology.

scientific article

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

scientific article (publication date: 7 January 2000)

Control of peripheral nerve myelination by the beta-secretase BACE1

scientific article

Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models

scientific article

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex

scientific article published in April 1996

Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor

scientific article

Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes

scientific article

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

scientific article published on 20 February 2021

Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease.

scientific article published on 24 May 2019

Differential Effects of Parkinson's Disease-associated Mutations on Stability and Folding of DJ-1 ⬇️

scientific article published on November 7, 2003

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

scientific article

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

scientific article

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

scientific article published on 6 October 2013

Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?

scientific article

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

scientific article published in January 1988

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

scientific article published on 27 September 2018

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

scientific article published on December 2016

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

scientific article published on 10 January 2019

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

scholarly article by Julia K Götzl published in September 2018

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

scientific article published on January 1997

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

scientific article published on 09 September 2018

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

scientific article published on 20 November 2013

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

scientific article published in April 2001

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

scientific article published on 6 July 2007

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

scientific article published on 01 March 1997

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

scientific article published on 10 March 2020

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

scientific article published on November 1998

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

scientific article

Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region

scientific article published on 26 March 2010

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy

scientific article

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

scientific article

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

scientific article

Frontotemporal dementia: from molecular mechanisms to therapy

scientific article published in August 2016

Function, regulation and therapeutic properties of beta-secretase (BACE1).

scientific article published on 20 January 2009

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

scientific article

Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity

scientific article

Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration ⬇️

scientific article published on 02 April 2013

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

scientific article

Games played by rogue proteins in prion disorders and Alzheimer's disease

scientific article published on October 2003

Gamma-secretase activity is associated with a conformational change of nicastrin

scientific article published on 18 March 2003

Gamma-secretase complex assembly within the early secretory pathway

scientific article

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

scientific article published in August 2009

Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons

scientific article published on 19 April 2022

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

scientific article published on 17 March 2016

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

scientific article published on 24 October 2007

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease

scientific article

Genomic editing opens new avenues for zebrafish as a model for neurodegeneration

scientific article published on 21 October 2013

Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

scientific article

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

scientific article

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

scientific article

Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology

scientific article

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

scientific article

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

scientific article published on 10 August 2020

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

scientific article published on 08 October 2020

Highly efficient targeted mutagenesis in mice using TALENs

scientific article published on 26 August 2013

How does parkin ligate ubiquitin to Parkinson's disease?

scientific article

Human BACE forms dimers and colocalizes with APP.

scientific article published on 9 July 2004

Human presenilin‐1, but not familial Alzheimer’s disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing ⬇️

scientific article published on April 1, 1997

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

scientific article published on 24 May 2002

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

scientific article published on 5 December 2002

Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects

scientific article published on 20 September 2019

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model

scientific article

Identification of distinct gamma-secretase complexes with different APH-1 variants

scientific article

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

scientific article

Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity

scientific article published on 13 June 2016

Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET.

scientific article published on 20 September 2013

Impaired protein degradation in FTLD and related disorders

scientific article

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

scientific article published on 15 January 2013

Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

scientific article

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage ⬇️

scientific article published on October 15, 1992

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

scientific article published on 01 August 2019

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

scientific article

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

scientific article published on July 1996

Inhibition of amyloid-β plaque formation by α-synuclein

scientific article

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

scientific article published on 14 September 2010

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

scientific journal article

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

scientific article published on June 1997

Intramembrane proteolysis by gamma-secretase

scientific article published on 23 July 2008

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases

scientific article published on 03 February 2009

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation

scientific article published on 3 September 2008

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

scientific article published on 10 November 2015

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

scientific article

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

scientific article published on 15 February 2018

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

scientific article published on July 2005

Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques

scientific article published in November 2000

Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET.

scientific article published on 31 May 2013

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

scientific article

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes ⬇️

scientific article published on March 11, 2013

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

scientific article published on 14 September 2020

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

scientific article published on 07 January 2019

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

scientific article published on 19 June 2012

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

scientific article

Masking of transmembrane-based retention signals controls ER export of gamma-secretase

scientific article

Massachusetts Alzheimer's Disease Research Center: progress and challenges

scientific article

Maturation and pro-peptide cleavage of beta-secretase

scientific article

Mechanisms of granulin deficiency: lessons from cellular and animal models

scientific article

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

scientific article

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

scientific article published on 01 December 1994

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

scientific article published on 8 April 2010

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

scientific article

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

scientific article

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion

scientific article published on 5 November 2007

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

scientific article published on 26 June 2012

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

scientific article published on 28 February 2012

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

scientific article published on 19 February 2016

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis

scientific article

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

scientific article published in July 1998

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

scientific article published in July 1994

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase

scientific article

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

scientific article published on May 2003

New hope for Alzheimer disease vaccine

scientific article published in November 2002

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

scientific article

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

scientific article published on 5 November 2003

Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules

scientific article published on September 1993

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein ⬇️

scientific article published on September 6, 2011

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila

scientific article published on 8 November 2014

O2-03-08 Glycosphingolipids regulate subcellular transport of the β-amyloid procursor protein and the generation of amyloid β-peptide

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

scientific article

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

scientific article

Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy

scientific article published on March 2005

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

scientific article published on 26 August 2002

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

scientific article published on 16 November 2012

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

scientific article

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

scientific article

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

scientific article

Parkinson's pathology in a fly.

scientific article published in March 2000

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

scientific article

Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

scientific article published on 26 February 2004

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

scientific article published on 22 October 2003

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

scientific article

Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2

scientific article

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

scientific article

Phosphorylation regulates intracellular trafficking of beta-secretase

scientific article published on 29 January 2001

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

scientific article

Pore-forming scissors? A first structural glimpse of gamma-secretase

scientific article published on 4 August 2006

Posttranslational Modifications of Amyloid Precursor Protein: Ectodomain Phosphorylation and Sulfation

scientific article published on January 1, 2000

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein ⬇️

scientific article published on April 21, 2003

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

article by Marcia B. Podlisny et al published January 1997 in Neurobiology of Disease

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

scientific article

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

scientific article published on 29 July 2002

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

scientific article

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

scientific article

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct

scientific article

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

scientific article (publication date: 22 November 2002)

Presenilins Are Processed by Caspase-type Proteases ⬇️

scientific article published on August 15, 1997

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

scientific article published on October 2002

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion ⬇️

scientific article published on 01 December 1991

Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596

scientific article published on 01 November 1993

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression

scientific article

Proteolytic Fragments of the Alzheimer's Disease Associated Presenilins-1 and -2 Are Phosphorylated in Vivo by Distinct Cellular Mechanisms ⬇️

scientific article published on April 28, 1998

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

scientific article

Proteolytic processing and degradation of Alzheimer's disease relevant proteins

scientific article

Proteolytic processing of Alzheimer’s disease associated proteins ⬇️

scientific article published on January 1, 1998

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

scientific article

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

scientific article published on May 1997

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase

scientific article

Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease

scientific article

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

scientific article published in April 2013

Reconstitution of gamma-secretase activity

scientific article published in May 2003

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition

scientific article

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin

scientific article published on 29 December 2015

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

scientific article

Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage

scientific article published in December 2004

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

scientific article

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

scientific article published on 14 April 2011

Regulatory RNA goes awry in Alzheimer's disease

scientific article published in July 2008

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage

scientific article

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

scientific article

Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43) ⬇️

scientific article published on May 4, 2012

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators

scientific article published in December 2006

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

scientific article published on 23 January 2006

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

scientific article

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

scientific article

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model ⬇️

scientific article published on December 1, 2001

Semagacestat's fall: where next for AD therapies?

scientific article

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

scientific article published in May 2001

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

scientific article published on May 2000

Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

scientific article

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

scientific article

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

scientific article published on January 2007

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

scientific article

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

scientific article (publication date: February 2007)

SorLA signaling by regulated intramembrane proteolysis

scientific article published on 10 March 2006

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

scientific article

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

scientific article published on July 1997

Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment

scientific article published on 12 November 2005

Stress granules in neurodegeneration – lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma ⬇️

scientific article published on 09 May 2013

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

scientific article

Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation

article

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

scientific article

TRAP1 rescues PINK1 loss-of-function phenotypes

scientific article published on 21 March 2013

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

scientific article published on 8 May 2017

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

scientific article

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

scientific article

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

scientific article

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

scientific article published in June 1992

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system

scientific article

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.

scientific article

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

scientific article

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

scientific article published on 21 March 2019

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

scientific article

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

scientific article published on 30 May 2017

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

scientific article

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

scientific article published on 01 August 2019

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding ⬇️

scientific article published on October 6, 2010

The Nicastrin ectodomain adopts a highly thermostable structure ⬇️

scientific article published on November 1, 2011

The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex

scientific article

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex ⬇️

scientific article published on February 6, 1998

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

scientific article

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

scientific article

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

scholarly article by Xianyuan Xiang published in September 2018

The biochemical and genetic odyssey to the function of a nicastrin-like protein

scientific article published on January 2004

The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research

scientific article

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

scientific article published on March 1999

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

scientific article published on 24 September 2003

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

scientific article

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

scientific article

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

scientific article published on 18 November 2004

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

scientific article published on January 1996

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

scientific article published on January 2008

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

scientific article published on March 1995

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects

scientific article

The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b) ⬇️

scientific article published on December 22, 2011

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

scientific article published on June 2010

Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study

scientific article

Trafficking and proteolytic processing of APP

scientific article

Translational Repression of the Disintegrin and Metalloprotease ADAM10 by a Stable G-quadruplex Secondary Structure in Its 5′-Untranslated Region ⬇️

scientific article published on November 7, 2011

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

scientific article

Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40

scientific article published on 01 October 1998

What do we learn from a few familial Alzheimer's disease cases?

scientific article published in January 1998

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

article by Miguel Ángel Araque Caballero et al published 1 October 2018 in Brain

Young microglia restore amyloid plaque clearance of aged microglia.

scientific article

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

scientific article published on October 1999

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

scientific article published on February 1993

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

scientific article

hFE65L influences amyloid precursor protein maturation and secretion

scientific article published on September 1999

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

scientific article published on 5 February 2013

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

scientific article

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics

scientific article published on 24 August 2020

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