List of works by Elaine Lai-Han Leung

(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.

scientific article

A novel KIF5B-ALK variant in nonsmall cell lung cancer.

scientific article

A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)

scientific article published on 19 May 2020

A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis

scientific article published on 17 July 2019

Accuracy or novelty: what can we gain from target-specific machine-learning-based scoring functions in virtual screening?

scientific article published on 08 January 2021

Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets

scientific article

Artificial Intelligence-Based Collaborative Filtering Method with Ensemble Learning for Personalized Lung Cancer Medicine without Genetic Sequencing

scientific article published on 23 June 2020

Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol

scientific article published on 3 August 2016

Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.

scientific article published on 21 March 2014

Chelidonine Selectively Inhibits the Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells through the EGFR-AMPK Pathway

scientific article published on 25 May 2020

Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains

scientific article published on 01 September 2018

Clinical diagnostic value of long non-coding RNAs in Colorectal Cancer: A systematic review and meta-analysis

scientific article published on 11 July 2020

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population

scientific article

Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations

scientific article published on 26 April 2016

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.

scientific article published on 18 March 2016

Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway

scientific article published on 08 April 2019

Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non-Small Cell Lung Cancer

scientific article published on 01 January 2019

Current strategies against COVID-19

scientific article published on 09 July 2020

Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening

scientific article published on 11 November 2020

Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway

scientific article published on 09 August 2020

Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations

scientific article

Early lung cancer diagnostic biomarker discovery by machine learning methods

scientific article published on 17 November 2020

Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020

scientific article published on 29 April 2020

Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis

scientific article published on 19 November 2020

Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report

scientific article published on 01 October 2020

Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation

scientific article

GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration

scientific article published on 18 February 2020

Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M

scientific article published on 09 July 2018

High-quality assembly of Dermatophagoides pteronyssinus genome and transcriptome reveals a wide range of novel allergens.

scientific article

Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.

scientific article published on 22 December 2017

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

scientific article published on 11 April 2017

Identification of Oxygenated Fatty Acid as a Side Chain of Lipo-Alkaloids in Aconitum carmichaelii by UHPLC-Q-TOF-MS and a Database

scientific article published on 31 March 2016

Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells

scientific article published on 14 November 2017

Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening.

scientific article published in March 2018

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer

scientific article published on 12 March 2019

Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC)

scientific article published on 10 July 2018

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

scientific article

Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing

scientific article published on 22 November 2017

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

scientific article published on 13 February 2018

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway

scholarly article by Huanling Lai et al published 2018 in Frontiers in Pharmacology

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.

scientific article

Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials

scientific article published on 14 September 2020

Long-term efficacy of Chinese medicine Bushen Capsule on cognition and brain activity in patients with amnestic mild cognitive impairment

scientific article published on 17 June 2019

Metabolites software-assisted flavonoid hunting in plants using ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry.

scientific article

Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy

scientific article published on 30 June 2020

Mutation of cysteine 46 in IKK-beta increases inflammatory responses

scientific article published on 10 September 2015

Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders

scientific article published on 21 January 2020

Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis

scientific article published on 13 April 2019

Network-based drug discovery by integrating systems biology and computational technologies

scientific article (publication date: July 2013)

Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.

scientific article published on 9 October 2017

Novel therapeutic strategy for cancer and autoimmune conditions: Modulating cell metabolism and redox capacity

scientific article published on 25 June 2018

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation.

scientific article published on 13 June 2018

Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation

scientific article published on 6 April 2010

Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS.

scientific article published on 19 May 2015

Rapid identification of new minor chemical constituents from Smilacis Glabrae Rhizoma by combined use of UHPLC-Q-TOF-MS, preparative HPLC and UHPLC-SPE-NMR-MS techniques.

scientific article published on 17 July 2015

Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.

scientific article published on 18 January 2016

Roles of Ion fluxes, metabolism and redox balance in cancer therapy

scientific article published on 29 October 2020

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

scientific article published on 19 May 2016

SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy.

scientific article

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations

scientific article published on 18 August 2017

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

scientific article published on 15 November 2016

Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.

scientific article published on 12 July 2017

Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases

scientific article published on 30 June 2017

Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation

scientific article published on 3 November 2015

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms.

scientific article

Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death.

scientific article published on 22 February 2017

The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.

scientific article

miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway

scientific article published on 13 December 2019

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

scientific article published on 19 July 2019

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