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List of works by Harald von Melchner

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

scientific article published on 6 August 2003

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

scientific article published in February 1994

A public gene trap resource for mouse functional genomics

scientific article published on June 2004

Adriamycin cardiotoxicity: a survey of 1273 patients

scientific article published on May 1, 1979

Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury ⬇️

scientific article published on April 19, 2013

CRISPR/Cas9 genome engineering in hematopoietic cells

scientific article published on 25 August 2018

CRISPR/Cas9-mediated generic protein tagging in mammalian cells

scientific article published on 22 February 2019

Commitment to differentiation of human promyelocytic leukemia cells (HL60): an all-or-none event preceded by reversible losses of self-renewal potential

scientific article

Differential seeding of injected hemopoietic precursor cells in the bone marrow and spleen of irradiated mice ⬇️

scientific article published on 01 January 1980

Disconnection of genes coding for self-renewal and differentiation: a possible mechanism of diversity in acute myeloid leukemias.

scientific article published in May 1985

Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung

scientific article

Disruption of genes regulated during hematopoietic differentiation of mouse embryonic stem cells ⬇️

scientific article published on June 1, 1998

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

scientific article

Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity

scientific article published on April 2009

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps

scientific article

Engineering embryonic stem cells with recombinase systems

scientific article

Enhanced gene trapping in mouse embryonic stem cells

scientific article

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells

scientific article

Fluorescence-activated sorting of totipotent embryonic stem cells expressing developmentally regulated lacZ fusion genes ⬇️

scientific article published on August 1, 1992

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

scientific article published on December 2011

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.

scientific article

Gene targeting and site-specific recombination in mouse ES cells

scientific article published in January 2013

Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration

scientific article published on 22 September 2008

Gene trapping identifies inhibitors of oncogenic transformation. The tissue inhibitor of metalloproteinases-3 (TIMP3) and collagen type I alpha2 (COL1A2) are epidermal growth factor-regulated growth repressors

scientific article published on May 1998

Gene trapping identifies transiently induced survival genes during programmed cell death

scientific article

Gene-trap vectors and mutagenesis

scientific article

Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

scientific article published on 19 April 2017

Genomewide Trapping of Genes that Encode Secreted and Transmembrane Proteins Repressed by Oncogenic Signaling ⬇️

scientific article published on November 1, 2001

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

scientific article published on 3 May 2005

Hemopoietic precursor cell regeneration following irradiation and syngeneic marrow transplantation ⬇️

scientific article published on January 1, 1983

High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing.

scientific article published on 10 November 2017

High throughput gene trapping and postinsertional modifications of gene trap alleles

scientific article published on 19 February 2011

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.

scientific article

Human placental conditioned medium reverses apparent commitment to differentiation of human promyelocytic leukemia cells (HL60).

scientific article

Identification of cellular promoters by using a retrovirus promoter trap

scientific article published on August 1989

Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific recombination

scientific article published on December 1996

In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: implications for autologous BMT

scientific article published on 01 February 1994

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

scientific article published on 27 January 2010

Isolation of cellular promoters by using a retrovirus promoter trap

scientific article

Isolation of murine fetal hemopoietic progenitor cells and selective fractionation of various erythroid precursors

scientific article published on 01 August 1981

Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development

scientific article

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5 ⬇️

scientific article published on February 4, 2013

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

scientific article

Mechanisms of Early Allogeneic Marrow Graft Rejection* ⬇️

scientific article published on January 1, 1983

Methods for extracting function from mammalian genomes

scientific article published on 01 April 2011

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms

scientific article

Modulation by serum from irradiated and marrow transplanted mice of hemopoietic regeneration in mouse spleen organ cultures

scientific article published on 01 July 1981

New methods for extracting function from the mammalian genome

scientific article published on 29 June 2019

New vectors for gene therapy

scientific article published in January 1998

Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death

scientific article

Regeneration of hemopoietic precursor cells in spleen organ cultures from irradiated mice: influence of genotype of cells injected and of the spleen microenvironment

scientific article published on 01 May 1981

Regeneration of transplanted allogeneic hemopoietic progenitor cells in mouse spleen organ cultures

scientific article published on November 1, 1981

Resources for proteomics in mouse embryonic stem cells.

scientific article published in February 2011

Retrovirus mediated gene transfer into hemopoietic cells

scientific article published on July 1988

Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells

scientific article published on March 1991

Retroviruses as genetic tools to isolate transcriptionally active chromosomal regions

scientific article

Reversible tumorigenesis in mice by conditional expression of the HER2/c-erbB2 receptor tyrosine kinase.

scientific article published on September 1996

Selective Disruption of Genes Transiently Induced in Differentiating Mouse Embryonic Stem Cells by Using Gene Trap Mutagenesis and Site-Specific Recombination ⬇️

scientific article published on May 1, 1998

Selective Disruption of Genes Transiently Induced in Differentiating Mouse Embryonic Stem Cells by Using Gene Trap Mutagenesis and Site-Specific Recombination.

scientific article published in October 1998

Selective disruption of genes expressed in totipotent embryonal stem cells

scientific article published on June 1, 1992

Self-deleting retrovirus vectors for gene therapy.

scientific article published on August 1996

Self-deleting suicide vectors (SDSV): selective killing of p53-deficient cancer cells.

scientific article

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions

scientific article

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

scientific article published on 29 August 2013

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal

scientific journal article

Splinkerette PCR for more efficient characterization of gene trap events

scientific article published on 01 August 2007

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by Alpha-Ketoglutarate and TET-TDG Functional Reactivation.

scientific article published on 20 November 2017

Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.

scientific article published on 18 April 2013

T lymphocyte-mediated graft--antigraft reactivity during graft-versus-host reaction in vitro

scientific article published on 01 April 1984

TGF-beta activation by traction?

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

scientific article

The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier

scientific article

The expression of neomycin phosphotransferase in human promyelocytic leukemia cells (HL60) delays their differentiation.

scientific article

The influence of T lymphocytes and their products on hemopoietic precursor cell regeneration in spleen organ cultures

scientific article published on 01 January 1983

The knockout mouse project

scientific article

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

scientific article

Unsung Hero Robert C. Gallo

scientific article

Use of spleen organ cultures in the analysis of hemopoietic alterations induced by irradiation and allogeneic marrow transplantation

scientific article published on January 1, 1983

Use of spleen organ cultures to monitor hemopoietic progenitor cell regeneration following irradiation and marrow transplantation

scientific article published on 01 November 1980

Wnt/beta-catenin signaling controls development of the blood-brain barrier

scientific article published on 27 October 2008

Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells.

scientific article published on 29 March 2018

[Etiology and pathogenesis of leukemia]

scientific article published on 01 November 1983

[Molecular mechanisms of hematopoietic stem cell differentiation]

scientific article published on 01 April 1995

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