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List of works by Christian Gespach

Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy

scientific article published on 01 June 2007

Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion.

scientific article published on December 2007

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts.

scientific article published on 28 September 2016

Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells

scientific article published in February 2004

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

scientific article published in January 2012

Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex

scientific article published on September 2006

Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells

scientific article

Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential

scientific article published on June 2008

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling ⬇️

scientific article published on April 25, 2012

CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells

scientific article published on 10 November 2020

Characterization of major elements of insulin signaling cascade in chicken adipose tissue: Apparent insulin refractoriness ⬇️

scientific article published on January 3, 2012

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

scientific article

Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment

scientific article published in December 2005

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding

scientific article published on 25 August 2004

Crosstalk between the cell cycle regulator Cdk2 and the Cdx2 tumor suppressor at the proliferation-differentiation interface

scientific article published in December 2005

Cyclooxygenase 2 and carcinogenesis

scientific article published in May 2004

Cyclooxygenase 2 and carcinogenesis

scientific article

Differential activation of adenylate cyclase by secretin and VIP receptors in the calf pancreas

scientific article published in August 2005

Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion

scientific article

Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression

scientific article published on 06 January 2013

Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cells

scientific article published on June 2004

Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes

scientific article published in April 2004

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

scientific article

Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells

scientific article published on 20 April 2010

Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression

scientific article published on June 2006

G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells

scientific article

Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors

scientific article published on January 2012

Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition

scientific article published on 30 April 2012

Implication of MYH in colorectal polyposis.

scientific article

Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.

scientific article

Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.

scientific article published on 14 September 2010

Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -inde

scientific article published on August 2005

Increasing Potential of HER3 Signaling in Colon Cancer Progression and Therapy ⬇️

scientific article published on December 28, 2011

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.

scientific article published on 11 November 2010

Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit

scientific article published on 31 July 2009

Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

scientific article published on 01 August 2006

Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle

scientific article published in June 2008

Insulin immuno-neutralization in fed chickens: effects on liver and muscle transcriptome

scientific article published on 3 January 2012

Modeling and quantification of cancer cell invasion through collagen type I matrices

scientific article published on January 2010

Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

scientific article published on 22 July 2008

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

scientific article published on 20 August 2008

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

scientific article

Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor

scientific article published in October 2008

Neurotensin receptor 1 determines the outcome of non-small cell lung cancer

scientific article published on September 2010

Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas

scientific article

Nuclear bodies and compartments: functional roles and cellular signalling in health and disease

scientific article published in October 2004

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

scientific article

Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.

scientific article

Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts

scientific article published on 9 May 2011

Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells

scientific article

Reciprocity in breast cancer progression

scientific article

Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse.

scientific article published on 4 August 2016

RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.

scientific article published on April 2002

Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells

scientific article

Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis.

scientific article published on 10 August 2011

Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells

scientific article published in July 2003

Signaling networks in cancer--an interview with Christian Gespach. Interview by Olivier De Wever

scientific article published in January 2011

Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells

scientific article

Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion.

scientific article published on 18 July 2003

Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.

scientific article published on April 2004

The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy.

scientific article

The cancer chemopreventive agent resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities.

scientific article published on May 2005

The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression

scientific article

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling

scientific article

The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion

scientific article published on September 2008

The tumor ecosystem regulates the roads for invasion and metastasis

scientific article published on 14 June 2011

Trefoil factor family (TFF) peptides and cancer progression

scientific article published on 01 May 2004

Trefoil factor family mRNA and protein expression in pterygium.

scientific article

Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling

scientific article

Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer

scientific article

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