List of works by Ulrich Keilholz

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.

scientific article published on 23 April 2009

A clinical development paradigm for cancer vaccines and related biologics

scientific article

A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours

scientific article published in September 2004

A monoclonal melanoma-specific T-cell population phenotypically indistinguishable from CD3+ LGL-leukemia

scientific article published on 01 June 2003

A phase I/IIa clinical trial of CLAOP21 and CLAOP14 in patients with high grade non-Hodgkins lymphoma.

scientific article published in September 2007

A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma

scientific article

A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma

scientific article published in October 2005

Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells

scientific article published on 19 July 2006

Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104).

scientific article published on January 2005

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

scientific article

Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of C

scientific article published on 11 May 2009

Afatinib as second-line treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: Subgroup analyses of treatment adherence, safety and mode of afatinib administration in the LUX-Head and Neck 1 trial

scientific article published on 23 August 2019

An intron 9 containing splice variant of PAX2.

scientific article

Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study).

scientific article published on 27 April 2013

Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment

scientific article published on 22 December 2009

Baseline caspase activity predicts progression free survival of temsirolimus-treated head neck cancer patients

scientific article published on 2 June 2015

CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia

scientific article published in September 2002

Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo

scientific article published on 10 March 2020

Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity

scientific article published on 01 March 2002

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

scientific article published on 28 September 2009

Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.

scientific article published in February 2007

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

article

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

scientific article

Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group

scientific article published in September 2005

Differences in T-cell immunity toward tumor-associated antigens in colorectal cancer and breast cancer patients

scientific article

Dose Seeking Evaluation of a Novel Heterologous Primeboost Immunotherapy in Stage III and IV Metastatic Melanoma Patients

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy

scientific article published on 18 December 2018

EORTC Melanoma Group achievements

scientific article published in March 2012

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

scientific article (publication date: 2016)

Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.

scientific article published in March 2003

Enhanced detection of BRAF-mutants by pre-PCR cleavage of wild-type sequences revealed circulating melanoma cells heterogeneity

scientific article published on 12 May 2011

Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine ⬇️

scientific article published on November 1, 2010

Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma

scientific article published on December 2007

Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma

scientific article published on February 2008

Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting.

scientific article published in April 2008

Expression and activity of EGFR in human cutaneous melanoma cell lines and influence of vemurafenib on the EGFR pathway

scientific article published on 15 May 2014

Expression of Wilms' tumor gene 1 at different stages of acute myeloid leukemia and analysis of its major splice variants.

scientific article published on 31 August 2004

Expression of chemokine receptors on circulating tumor cells in patients with solid tumors

scientific article published on 20 March 2012

Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

scientific article

Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients

scientific article published on 11 January 2016

Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines

scientific article

Functional CCR9 expression is associated with small intestinal metastasis

scientific article published on March 2004

Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1.

scientific article published on December 2006

Identification of an immunogenic HLA-A*0201-binding T-cell epitope of the transcription factor PAX2.

scientific article published on May 2009

Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment.

scientific article published in March 2002

Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study

scientific article published in August 2005

Immune monitoring of T-cell responses in cancer vaccine development

scientific article

Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy.

scientific article

Immunological monitoring of cancer vaccine therapy

scientific article published in October 2004

In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype

scientific article

Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma.

scientific article

Innovations and challenges in melanoma: summary statement from the first Cambridge conference

scientific article published on 01 April 2006

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

scientific article published on 4 May 2009

Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensi

scientific article published on 17 January 2016

Long term presence of a single predominant tyrosinase-specific T-cell clone associated with disease control in a patient with metastatic melanoma

scientific article

Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides

scientific article published in May 2002

Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma

scientific article (publication date: July 2007)

Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma

scientific article published on 24 September 2012

Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2

scientific article published on 22 December 2005

Malignant melanoma--clinical development of peptide-based melanoma vaccines

scientific article

Natural T cell immunity against cancer.

scientific article published on October 2003

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

scientific article published on 19 May 2011

PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients with head and neck squamous cell carcinoma receiving cetuximab-docetaxel.

scientific article

Peptide vaccination after repeated resection of metastases can induce a prolonged relapse-free interval in melanoma patients.

scientific article published in May 2005

Phase II trial of carboplatin, paclitaxel plus vinorelbine in non-small cell lung cancer patients.

scientific article published in March 2005

Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma

scientific article

Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients

scientific article

Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial

scientific article

Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial

scientific article published on 01 April 2007

Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts

scientific article published on 12 June 2020

Quantitative detection of circulating tumor cells in cutaneous and ocular melanoma and quality assessment by real-time reverse transcriptase-polymerase chain reaction

scientific article published in March 2004

Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease

scientific article published on March 2002

Quantitative real-time RT-PCR for detection of disseminated tumor cells in peripheral blood of patients with colorectal cancer using different mRNA markers.

scientific article published in January 2004

Randomized phase II study of paclitaxel and carboplatin or vinorelbine in advanced non-small cell lung cancer.

scientific article published in January 2011

Rational peptide-based tumour vaccine development and T cell monitoring

scientific article published on December 2003

Relative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations

scientific article published on July 2008

Restricted T-cell receptor repertoire in melanoma metastases regressing after cytokine therapy.

scientific article

Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

scientific article

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.

scientific article published on 13 April 2018

Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma

scientific article

Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits

scientific article published on February 2008

Sex is an independent prognostic indicator for survival and relapse/progression-free survival in metastasized stage III to IV melanoma: a pooled analysis of five European organisation for research and treatment of cancer randomized controlled trials

scientific article published on 20 May 2013

Short German guidelines: Merkel cell carcinoma

scientific article published in May 2008

Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib

scientific article published on 24 March 2009

T cell responses against tumor associated antigens and prognosis in colorectal cancer patients

scientific article

The EORTC-DeCOG nomogram adequately predicts outcomes of patients with sentinel node-positive melanoma without the need for completion lymph node dissection

scientific article published on 23 May 2020

The Evolving Role of Taxanes in Combination With Cetuximab for the Treatment of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck: Evidence, Advantages, and Future Directions

scientific article published on 21 August 2019

Transarterial chemoembolization of liver metastases from uveal melanoma after failure of systemic therapy: toxicity and outcome

scientific article

UV-induced N-ras mutations are T-cell targets in human melanoma

article

Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991.

scientific article published on 5 November 2011

Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome

scientific article published on 29 April 2009

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