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List of works by D. Gray Heppner

A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.

scientific article

A field trial to assess a blood-stage malaria vaccine

scientific article published on September 2011

A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults

scientific article published on 30 May 2007

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

scientific article published in January 1997

Activation of gammadelta T cells in malaria: interaction of cytokines and a schizont-associated Plasmodium falciparum antigen

scientific article

Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques

scientific article

Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice

scientific article published on 16 April 2008

Antimalarial properties of orally active iron chelators.

scientific article published in July 1988

Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial

scientific article

Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum

scientific article published on June 1994

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya

scientific article

Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial

scientific article published on 31 January 2009

Characterization of a human reference standard for antibody to Plasmodium falciparum merozoite surface protein 1(42).

scientific article published on June 2005

Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic

scientific article

Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.

scientific article

Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria ⬇️

scientific article published on January 1, 1998

Comparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand

scientific article published in October 1999

CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1(19)) formulated in oil-ba

scientific article

Culture of malaria parasites in two different red blood cell populations using biotin and flow cytometry

scientific article published in November 1996

Current strategic thinking for the development of a trivalent alphavirus vaccine for human use

scientific article

Cutaneous delayed-type hypersensitivity (DTH) in a multi-formulation comparator trial of the anti-falciparum malaria vaccine candidate RTS,S in rhesus macaques

scientific article published on 5 July 2006

Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine

scientific article published in May 2003

Development of RTS,S/AS02: a purified subunit-based malaria vaccine candidate formulated with a novel adjuvant

scientific article

Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen

scientific article

Effects of hydroxypyridinone iron chelators in combination with antimalarial drugs on the in vitro growth of Plasmodium falciparum

scientific article published on March 2001

Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

scientific article published on 24 January 2001

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

scientific article published on 25 May 2003

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

scientific article

Evaluation of recurrent parasitemia after artemether-lumefantrine treatment for uncomplicated malaria in children in western Kenya

scientific article

Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys.

scientific article published on 24 October 2009

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

scientific article published in February 2010

Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial

scientific article

Field trials of an asexual blood stage malaria vaccine: studies of the synthetic peptide polymer SPf66 in Thailand and the analytic plan for a phase IIb efficacy study.

scientific article published in January 1995

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

scientific article published on 8 September 2013

Hb G-Philadelphia or Stanleyville II? When the phenotype and genotype do not agree

scientific article published on 02 July 2007

Hb Kenya among Luo adults and young children in malaria holoendemic Western Kenya: screened by high performance liquid chromatography and confirmed by polymerase chain reaction

scientific article

Heterologous prime-boost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02A.

scientific article published on 6 March 2006

High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model

scientific article (publication date: 3 December 2009)

Human ehrlichiosis in Thailand ⬇️

scientific article published on September 13, 1997

Immunization with the RTS,S/AS malaria vaccine induces IFN-γ+CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge ⬇️

scientific article published on October 5, 2011

Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial

scientific article

Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

scientific article

In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand

scientific article published on January 1999

In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials

scientific article published on February 1997

Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein

scientific article published in May 2004

Isolation and characterization of rhesus blood dendritic cells using flow cytometry

scientific article published in June 2001

Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway

scientific article published in April 2004

Malaria in 1998: advances in diagnosis, drugs and vaccine development

scientific article published in October 1998

Malaria rapid diagnostic devices: performance characteristics of the ParaSight F device determined in a multisite field study.

scientific article

Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria

scientific article published on 11 February 2008

Malaria vaccines: triumphs or tribulations?

scientific article

Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications

scientific article published on 29 November 2012

Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A

scientific article published on 13 November 2006

New World monkey efficacy trials for malaria vaccine development: critical path or detour?

scientific article published in September 2001

Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine

scientific article published in January 2003

Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.

scientific article

Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya

scientific article published on 7 December 2005

Phase 1 safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya

scientific article published in July 2006

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

scientific article

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

scientific article published on 13 March 2008

Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.

scientific article published on 26 March 2007

Phase I safety and immunogenicity testing of clinical lots of the synthetic Plasmodium falciparum vaccine SPf66 produced under good manufacturing procedure conditions in the United States.

scientific article published in July 1996

Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine

scientific article published on 28 November 2005

Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia

scientific article published in May 1997

Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine

scientific article

Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.

scientific article published on 3 July 2006

Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alum

scientific article published in September 2004

Pre-erythrocytic malaria vaccines to prevent Plasmodium falciparum malaria.

scientific article

Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates

scientific article published on 22 October 2007

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

scientific article (publication date: 4 August 2009)

Primaquine prophylaxis against malaria

scholarly article by D. Gray Heppner et al published 16 March 1999 in Annals of Internal Medicine

Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone

scientific article published on 16 February 2007

Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum

scientific article

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

scientific article (publication date: 15 April 2002)

Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma

scientific article published in December 2003

Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells

scientific article (publication date: 2011)

Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli

scientific article

Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand. Shoklo SPf66 Malaria Vaccine Trial Group

scientific article

Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse

scientific article published on 24 September 2004

Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand.

scientific article

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

scientific article

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

scientific article published on 6 September 2009

Regulation of Leukocyte Adhesion Molecules CD11b/CD18 and Leukocyte Adhesion Molecule-1 on Phagocytic Cells Activated by Malaria Pigment ⬇️

scientific article published on October 1, 1997

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01.

scientific article published on 23 January 2013

SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand.

scientific article published in September 1997

Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial

scientific article

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge

scientific article

Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial

scientific article

Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial

scientific article

Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys.

scientific article

Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children

scientific article published on September 19, 1992

Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1-4 in Mozambique.

scientific article published on January 2007

Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study

scientific article published on 9 June 2017

Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children

scientific article published on 15 April 2005

Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children

scientific article

Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes

scientific article published on August 1996

Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine

scientific article published in June 1995

Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.

scientific article published in April 2004

Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans.

scientific article published in April 1994

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults

scientific article published on 18 June 2014

Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine

scientific article

Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate

scientific article published on 14 April 2016

The dog that did not bark: malaria vaccines without antibodies

scientific article published on 18 May 2007

The malaria vaccine – Status quo 2013 ⬇️

scientific article published on January 1, 2013

Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

scientific article

Update on the clinical development of candidate malaria vaccines.

scientific article published in August 2004

Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides

scientific article published on 01 January 2001

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment

scientific article published on 29 January 2019

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