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List of works by Laurence Patterson

A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.

scientific article published in July 2005

AQ4N: a new approach to hypoxia-activated cancer chemotherapy

scientific article

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo

scientific article published on July 1995

An agarose spot chemotaxis assay for chemokine receptor antagonists.

scientific article published on February 2011

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

Antitumour prodrug development using cytochrome P450 (CYP) mediated activation

scientific article

Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N.

scientific article published in January 2003

Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy

scientific article

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

scientific article published on October 2013

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

scientific article published on 15 April 2013

Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling

scientific article published on 11 February 2007

DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells

scientific article

DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

scientific article

Design and synthesis of a DNA-crosslinking azinomycin analogue.

scientific article published on 5 September 2005

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

scientific article published on July 27, 2010

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

scientific article published on October 2005

Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists

scientific article

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

scientific article published on June 2000

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

scientific article published on April 2000

Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation

scientific article published on July 1996

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

scientific article

Improved preparation and detection of cytochrome P450 isoforms using MS methods

scientific article

Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones

scientific article published on 20 September 2016

Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug

scientific article published on 01 November 1998

Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres

scientific article

Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry

scientific article

NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7.

scientific article published on 28 May 2013

Nipple aspirate fluid-A liquid biopsy for diagnosing breast health.

scientific article published on 10 May 2017

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

scientific article (publication date: 2013)

Protein deregulation associated with breast cancer metastasis

scientific article published on 31 May 2015

RGD-Binding Integrins in Head and Neck Cancers

scientific article

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis.

scientific article published on 26 October 2012

Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450

scientific article published on 06 May 2016

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Resistance in cancer: a target for drug discovery.

scientific article published in September 2004

Royal academy of medicine in Ireland section of biomedical sciences

Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells

scientific article

Steve Paschal Kenyon, M.D.

scientific article

Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists.

scientific article published on 07 March 2014

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

scientific article published on November 2006

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression

scientific article published on 3 October 2016

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N

scientific article

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N.

scientific article published on 12 November 2002

The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.

scientific article

The use of thermographic imaging to evaluate therapeutic response in human tumour xenograft models.

scientific article published on 05 August 2016

Truncated azinomycin analogues intercalate into DNA.

scientific article published on February 2005

Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N.

scientific article published on June 2006

Use of the hollow fiber assay for the evaluation of DNA damaging agents.

scientific article published on 30 April 2011

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