List of works - Alvaro José Romanha

A diterpene from Mikania obtusata active on Trypanosoma cruzi

A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation

scientific article published in May 2008

Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection

scientific article published on 10 November 2008

Antibacterial, antifungal and antiprotozoal activities of fungal communities present in different substrates from Antarctica

Arylfurans as potential trypanosoma cruzi trypanothione reductase inhibitors

scientific article published on 01 March 2006

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

scientific article

Autochthonous canine visceral leishmaniasis in a non-endemic area: Bom Sucesso, Minas Gerais State, Brazil

scientific article

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

scientific article

Biogeography of Brazilian populations of Panstrongylus megistus (Hemiptera, Reduviidae, Triatominae) based on molecular marker and paleo-vegetational data

scientific article

Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus

scientific article

CA88, a nuclear repetitive DNA sequence identified in Schistosoma mansoni, aids in the genotyping of nine Schistosoma species of medical and veterinary importance

scientific article published in July 2010

Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi

scientific article published on 5 March 2009

Characterization of trypanosomes from the subgenus Schizotrypanum isolated from bats, Eptesicus sp. (Chiroptera: Vespertilionidae), captured in Florianópolis, Santa Catarina State, Brazil

scientific article published on June 1998

Comparison of polymerase chain reaction with other laboratory methods for the diagnosis of American cutaneous leishmaniasis: diagnosis of cutaneous leishmaniasis by polymerase chain reaction.

scientific article

Cytotoxic, immunosuppressive and trypanocidal activities of agrocybin, a polyacetylene produced by Agrocybe perfecta (Basidiomycota)

Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.

scientific article published on 27 December 2005

Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole

scientific article

Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity

scientific article published on November 2003

Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica

scientific article published on 23 May 2013

Diversity and bioprospection of fungal community present in oligotrophic soil of continental Antarctica

scientific article published on 26 March 2015

Diversity patterns, ecology and biological activities of fungal communities associated with the endemic macroalgae across the Antarctic peninsula

scientific article

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

article

Dynamics between sylvatic, peridomestic and domestic populations of Triatoma brasiliensis (Hemiptera: Reduviidae) in Ceara State, Northeastern Brazil.

scientific article published in January 2005

Evaluation of compliance through specific interviews: a prospective study of 73 children with acute lymphoblastic leukemia

scientific article published in May 2005

Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice

Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure

scientific article published on 16 August 2002

First report on the occurrence of Trypanosoma rangeli Tejera, 1920 in the state of Ceará, Brazil, in naturally infected triatomine Rhodnius nasutus Stål, 1859 (Hemiptera, Reduviidae, Triatominae).

scientific article published in August 2007

Fungi associated with rocks of the Atacama Desert: taxonomy, distribution, diversity, ecology and bioprospection for bioactive compounds

scientific article published on 31 July 2015

Genome and genomics of schistosomes

scientific article published in 2004

Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli

scientific article published in September 2014

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

scientific article published on 29 May 2015

In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease

scientific article

In vitro and in vivo experimental models for drug screening and development for Chagas disease

scientific article published in March 2010

In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)

In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi ⬇️

scientific article published on 01 January 2003

In vitro interaction between paromomycin sulphate and four drugs with leishmanicidal activity against three New World Leishmania species

scientific article

In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

scientific article published on 8 April 2011

Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole

scientific article published on 20 November 2006

Infectivity of seropositive dogs, showing different clinical forms of leishmaniasis, to Lutzomyia longipalpis phlebotomine sand flies.

scientific article published on 20 April 2007

Interpopulation variability among Panstrongylus megistus (Hemiptera: Reduviidae) from Brazil.

scientific article

Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues.

scientific article

Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi

article

Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages.

scientific article published on May 2017

Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl

scientific article

Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil

scientific article published on April 2010

Low-stringency single specific primer PCR for identification of Leptospira

scientific article published on 01 February 2003

Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole

scientific article published on 20 November 2014

Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole

scientific article published on 19 November 2008

Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole

scientific article

Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi

scientific article

Molecular phylogeny, diversity, symbiosis and discover of bioactive compounds of endophytic fungi associated with the medicinal Amazonian plant Carapa guianensis Aublet ( Meliaceae )

article

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

scientific article

New bioactive coumarins from Kielmeyera albopunctata.

scientific article published on May 2003

New evidence of spontaneous cure in human Chagas' disease ⬇️

scientific article published on January 1, 2003

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

scientific article published on 26 July 2018

PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis

scientific article published on 01 March 2004

Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

scientific article

Population dynamics of Triatoma vitticeps (Stål, 1859) in Itanhomi, Minas Gerais, Brazil

scientific article

Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats

scientific article

Sensitivity and reproducibility of a PCR assay for Leishmania detection using skin biopsy imprints on filter paper

scientific article published on 18 October 2008

Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line

scientific article published on 11 February 2003

Susceptibility of Triatoma brasiliensis from state of Ceará, Northeastern Brazil, to the pyrethroid deltamethrin

scientific article published in May 2010

Susceptibility of triatoma infestans to deltamethrin in Rio Grande do Sul, Brazil

scientific article published in July 2009

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

scientific article published on 9 February 2017

Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds

scientific article published on 08 September 2011

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

scientific article

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

scientific article

Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity.

scientific article

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

scientific article

Synthesis of new thiosemicarbazones and semicarbazones containing the 1,2,3-1H-triazole-isatin scaffold: trypanocidal, cytotoxicity, electrochemical assays, and molecular docking

scientific article published on 01 January 2019

Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase

The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole

scientific article published on 12 January 2007

The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi

scientific article published on 01 December 2011

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

scientific article published on November 2010

The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

scientific article published on 25 April 2014

The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil

scientific article

The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.

scientific article published in June 2012

Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data

scientific article

Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli

scientific article published on 24 April 2014

Trypanocidal components ofPluchea quitoc L

scholarly article by Carlos Leomar Zani et al published September 1994 in Phytotherapy Research

Trypanosoma cruzi: characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations

scientific article published on 12 June 2007

Trypanosoma cruzi: multiplex PCR to detect and classify strains according to groups I and II.

scientific article

Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal

scientific article published on 29 June 2016

Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress

scientific article published in June 2015

Use of PCR-RFLP to identify Leishmania species in naturally-infected dogs.

scientific article

List of works by Alvaro José Romanha

A diterpene from Mikania obtusata active on Trypanosoma cruzi

A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation

Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection

Antibacterial, antifungal and antiprotozoal activities of fungal communities present in different substrates from Antarctica

Arylfurans as potential trypanosoma cruzi trypanothione reductase inhibitors

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

Autochthonous canine visceral leishmaniasis in a non-endemic area: Bom Sucesso, Minas Gerais State, Brazil

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Biogeography of Brazilian populations of Panstrongylus megistus (Hemiptera, Reduviidae, Triatominae) based on molecular marker and paleo-vegetational data

Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus

CA88, a nuclear repetitive DNA sequence identified in Schistosoma mansoni, aids in the genotyping of nine Schistosoma species of medical and veterinary importance

Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi

Characterization of trypanosomes from the subgenus Schizotrypanum isolated from bats, Eptesicus sp. (Chiroptera: Vespertilionidae), captured in Florianópolis, Santa Catarina State, Brazil

Comparison of polymerase chain reaction with other laboratory methods for the diagnosis of American cutaneous leishmaniasis: diagnosis of cutaneous leishmaniasis by polymerase chain reaction.

Cytotoxic, immunosuppressive and trypanocidal activities of agrocybin, a polyacetylene produced by Agrocybe perfecta (Basidiomycota)

Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.

Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole

Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity

Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica

Diversity and bioprospection of fungal community present in oligotrophic soil of continental Antarctica

Diversity patterns, ecology and biological activities of fungal communities associated with the endemic macroalgae across the Antarctic peninsula

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

Dynamics between sylvatic, peridomestic and domestic populations of Triatoma brasiliensis (Hemiptera: Reduviidae) in Ceara State, Northeastern Brazil.

Evaluation of compliance through specific interviews: a prospective study of 73 children with acute lymphoblastic leukemia

Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice

Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure

First report on the occurrence of Trypanosoma rangeli Tejera, 1920 in the state of Ceará, Brazil, in naturally infected triatomine Rhodnius nasutus Stål, 1859 (Hemiptera, Reduviidae, Triatominae).

Fungi associated with rocks of the Atacama Desert: taxonomy, distribution, diversity, ecology and bioprospection for bioactive compounds

Genome and genomics of schistosomes

Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease

In vitro and in vivo experimental models for drug screening and development for Chagas disease

In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)

In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi ⬇️

In vitro interaction between paromomycin sulphate and four drugs with leishmanicidal activity against three New World Leishmania species

In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole

Infectivity of seropositive dogs, showing different clinical forms of leishmaniasis, to Lutzomyia longipalpis phlebotomine sand flies.

Interpopulation variability among Panstrongylus megistus (Hemiptera: Reduviidae) from Brazil.

Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues.

Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi

Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages.

Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl

Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil

Low-stringency single specific primer PCR for identification of Leptospira

Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole

Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole

Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole

Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi

Molecular phylogeny, diversity, symbiosis and discover of bioactive compounds of endophytic fungi associated with the medicinal Amazonian plant Carapa guianensis Aublet ( Meliaceae )

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

New bioactive coumarins from Kielmeyera albopunctata.

New evidence of spontaneous cure in human Chagas' disease ⬇️

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis

Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

Population dynamics of Triatoma vitticeps (Stål, 1859) in Itanhomi, Minas Gerais, Brazil

Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats

Sensitivity and reproducibility of a PCR assay for Leishmania detection using skin biopsy imprints on filter paper

Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line

Susceptibility of Triatoma brasiliensis from state of Ceará, Northeastern Brazil, to the pyrethroid deltamethrin

Susceptibility of triatoma infestans to deltamethrin in Rio Grande do Sul, Brazil

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Synthesis of new thiosemicarbazones and semicarbazones containing the 1,2,3-1H-triazole-isatin scaffold: trypanocidal, cytotoxicity, electrochemical assays, and molecular docking

Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase

The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole

The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil

The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.

Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data

Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli