List of works by Yvonne P Dragan

5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets

scientific article published on July 1990

Acute effects of some volatile nitrites on motor performance and lethality in mice

scientific article published in March 1986

Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats

journal article published in 2004

An Integrated Multi-Omics Analysis Defines Key Pathway Alterations in a Diet-Induced Obesity Mouse Model

scientific article published on 25 February 2020

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay

scientific article published on April 1991

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms.

scientific article published in January 2006

Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion

scientific article

Biochemical events during initiation of rat hepatocarcinogenesis

scientific article published on 01 July 1994

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat ⬇️

scientific article published on June 1, 1991

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

scientific article

Biomarkers of carcinogenicity and their roles in drug discovery and development.

scientific article published in November 2008

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity

scientific article published on 28 July 2013

Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months

scientific article published on 01 April 2000

Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat

scientific article published on August 1, 1992

Chemicals, cell proliferation, risk estimation, and multistage carcinogenesis

scientific article published on January 1991

Comparison of Basal gene expression in cultured primary rat hepatocytes and freshly isolated rat hepatocytes

scientific article published on 01 January 2004

Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis

scientific article published on September 1995

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion

scientific article

Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat.

scientific article published on January 1989

Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression

scientific article published on July 1996

Developing microphysiological systems for use as regulatory tools--challenges and opportunities

scientific article published on January 2014

Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models.

scientific article published in March 2017

Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation

scientific article published on 01 January 1999

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

scientific article

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

scientific article

Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology

scientific article published on 6 October 2015

Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers

scientific article published on 4 November 2013

Effect of adenine nucleotides on cyclooxygenase and lipoxygenase enzyme products of arachidonic acid in human platelets

scientific article published on January 1990

Effect of chronic administration of mestranol, tamoxifen, and toremifene on hepatic ploidy in rats

scientific article published on June 1998

Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.

scientific article

Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus.

scientific article published in April 1997

Effects of phenobarbital on I-compounds in liver DNA as a function of age in male rats fed two different diets ⬇️

scientific article published on January 1, 1992

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver

scientific article published on 01 April 1995

Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth

scientific article published on 01 October 1998

Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications

scientific article published on 10 May 2012

Evaluation of temporal changes in urine-based metabolomic and kidney injury markers to detect compound induced acute kidney tubular toxicity in beagle dogs

scientific article published on 13 July 2017

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

scientific article published on 6 December 2008

Facts and theories concerning the mechanisms of carcinogenesis ⬇️

scientific article published on June 1, 1991

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

scientific article published on 20 January 2017

Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats

scientific article

Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.

scientific article

Hazard assessment of chemical carcinogens: the impact of hormesis.

scientific article

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

scientific article published on 05 March 2013

Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen

scientific article

Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example

scientific article

Implications of hormesis on the bioassay and hazard assessment of chemical carcinogens

scientific article

Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra

scientific article

Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis

scientific article published on September 1994

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.

scientific article

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

scientific article

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

scientific article

Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat

scientific article published on 01 July 1996

LETTERS TO THE EDITOR

article

Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds

scientific article published on 01 February 2000

Mechanisms of susceptibility to mouse liver carcinogenesis

scientific article published on January 1998

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.

scientific article published on 12 April 2008

Microarray Analysis Using Amplified mRNA from Laser Capture Microdissection of Microscopic Hepatocellular Precancerous Lesions and Frozen Hepatocellular Carcinomas Reveals Unique and Consistent Gene Expression Profiles ⬇️

scientific article published on May 1, 2003

Minisymposium on emerging methods in cancer hazard identification

scientific article published on 01 March 1997

Mode of action in relevance of rodent liver tumors to human cancer risk.

scientific article published on 12 October 2005

Multiple polypeptide hormone expression in pancreatic islet cell carcinomas derived from phosphoenolpyruvatecarboxykinase-SV40 T antigen transgenic rats

scientific article

Multistage hepatocarcinogenesis in the rat: insights into risk estimation

scientific article published on January 1, 1992

Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis.

scientific article published on July 1999

Nakahara Memorial Lecture. Pathways of carcinogenesis--genetic and epigenetic

scientific article published on 01 January 1991

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

scientific article published in January 2017

New Phenotypic Cytotoxicity Assay for ROS-inducing Compounds using Rat Renal Epithelial Cells

scientific article published on 06 June 2020

Optimization of an assay for studying the effects of agents on cyclooxygenase and lipoxygenase metabolism of arachidonic acid in washed human platelets

scientific article

P53-M Real-Time PCR Array for Multi-Gene Expression Profiling and Microarray Data Validation: RT2 Profiler PCR Array.

scientific article published in February 2007

Polygenic architecture informs potential vulnerability to drug-induced liver injury

scientific article published on 07 September 2020

Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS).

scientific article

Quantitation of multistage carcinogenesis in rat liver

scientific article published on January 1996

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury

scholarly article by Diane M Longo et al published 5 October 2018 in Toxicological Sciences

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.

scientific article published in October 1999

Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.

scientific article published in February 1993

Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats

scientific article published in January 1997

Rat toxicogenomic study reveals analytical consistency across microarray platforms

scientific article

Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease

scientific article

Role of altered hepatic foci in the stages of carcinogenesis

scientific article published on January 1990

STEREO: a program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents

scientific article published in April 1998

Selective loss of nucleoside carrier expression in rat hepatocarcinomas.

scientific article published on August 2000

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

scientific article published on 01 January 2007

Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms ⬇️

scientific article published on August 15, 1997

Stage of tumor progression, progressor agents, and human risk

scientific article published on January 1993

Structure-activity relationships for triphenylethylene antiestrogens on hepatic phase-I and phase-II enzyme expression

scientific article published on August 1998

Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats

scientific article published on January 1994

Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo.

scientific article published in May 1991

Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats.

scientific article published in July 1994

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

scientific article

The accurate prediction of protein family from amino acid sequence by measuring features of sequence fragments.

scientific article published in December 2009

The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage.

scientific article published in August 1998

The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

scientific article published on March 1996

The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.

scientific article published in March 1993

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.

scientific article published in June 1991

The initiation-promotion-progression model of rat hepatocarcinogenesis

scientific article published on January 1993

The instability of tumor promotion in relation to human cancer risk

scientific article published on January 1995

The multistage nature of chemically induced hepatocarcinogenesis in the rat.

scientific article published on January 1994

The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: Transforming growth factor α expression as a marker for the stage of progression ⬇️

scientific article published on June 29, 1995

The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat.

scientific article

Transgene expression and repression in transgenic rats bearing the phosphoenolpyruvate carboxykinase-simian virus 40 T antigen or the phosphoenolpyruvate carboxykinase-transforming growth factor-alpha constructs

scientific article published on July 1999

Transgenic hepatocarcinogenesis in the rat

scientific article published in August 1994

Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis ⬇️

scientific article published on January 1, 1991

Understanding drug-cytokine synergistic toxicity

scientific article published on 19 November 2015

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

scientific article published on 29 April 2010

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