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List of works by Henry C Pitot

3′,5′-cyclic AMP and the release of polysone-bound proteins in vitro ⬇️

scientific article published on 01 November 1967

A Mouse Model for Human Anal Cancer ⬇️

scientific article published on October 6, 2010

A North Central Cancer Treatment Group Phase II trial of 9-aminocamptothecin in previously untreated patients with measurable metastatic colorectal carcinoma

scientific article

A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.

scientific article published in March 2002

A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer

scientific article

A Phase II study of high-dose paclitaxel in patients with advanced neuroendocrine tumors

scientific article published on 01 April 2001

A Prospective Genome-Wide Study of Prostate Cancer Metastases Reveals Association of Wnt Pathway Activation and Increased Cell Cycle Proliferation with Primary Resistance to Abiraterone Acetate-Prednisone.

scientific article published on 23 October 2017

A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.

scientific article

A comparison of polysomal messenger ribonucleoprotein particles from normal and neoplastic rat liver ⬇️

scientific article published on July 1, 1978

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

scientific article (publication date: 19 January 1990)

A method for the comparative study of replicative DNA synthesis in GGT-positive and GGT-negative hepatocytes in primary culture isolated from carcinogen-treated rats

scientific article published on 01 October 1988

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

scientific article

A new thiol proteinase from rat liver

scientific article

A partial characterization of human fibroblast plasma membranes isolated by the fluorescein mercuric acetate method of Barland and Schroeder

scientific article published on May 1, 1977

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

scientific article

A phase I and pharmacokinetic study of a powder-filled capsule formulation of oral irinotecan (CPT-11) given daily for 5 days every 3 weeks in patients with advanced solid tumors

scientific article published on 19 November 2005

A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer

scientific article published in August 2002

A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, Velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies

scientific article

A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer

scientific article

A phase I study of radiation therapy and twice-weekly gemcitabine and cisplatin in patients with locally advanced pancreatic cancer

scientific article

A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin

scientific article published in October 2002

A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer.

scientific article

A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662, in combination with paclitaxel and carboplatin in patients with advanced cancer.

scientific article

A phase IB study of the pharmacokinetics of gemcitabine and pemetrexed, when administered in rapid sequence to patients with advanced solid tumors

scientific article

A phase II safety and efficacy study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor pazopanib in patients with metastatic urothelial cancer

scientific article

A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma

scientific article

A phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma

scientific article published on 01 June 1992

A phase II trial of 17-allylamino-17- demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

scientific article

A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

scientific article

A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.

scientific article

A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.

scientific article

A role for HPV16 E5 in cervical carcinogenesis

scientific article

A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat

scientific article published on 01 January 1989

A software package to improve image quality and isolation of objects of interest for quantitative stereology studies of rat hepatocarcinogenesis

scientific article

ADP-ribosyltransferase activity in cultured hepatocytes. Interactions with DNA repair ⬇️

scientific article published on May 25, 1982

ALTERED TEMPLATE STABILITY: THE MOLECULAR MASK OF MALIGNANCY?

scientific article published on 01 January 1964

Abnormal cholesterol uptake, storage, and synthesis in the livers of 2-acetylaminofluorene-fed rats

scientific article published on 01 June 1973

Abnormal proteins in Drosophila melanogaster subsequent to 5-bromodeoxyuridine administration

scientific article published in January 1974

Accumulation of actin microfilaments in adult rat hepatocytes cultured on collagen gel/nylon mesh

scientific article published in December 1980

Acetylated polyamines as substrates for human pregnancy serum diamine oxidase

scientific article published on 01 November 1981

Acetylation of nascent polypeptide chains on rat liver polyribosomes in vivo and in vitro ⬇️

scientific article published on April 8, 1975

Acetylation of ribosome-associated proteins in vitro by an acetyltransferase bound to rat liver ribosomes ⬇️

scientific article published on April 8, 1975

Action of actinomycin D on tryptophan uptake in the adrenalectomized rat and its effect on induction of tryptophan pyrrolase and tyrosine transaminase in liver

scientific article published on 01 September 1970

Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver

scientific article published on 01 December 1985

Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma

scientific article published in January 2002

Adventures in hepatocarcinogenesis

scientific article published on January 2007

Aging and cancer: some general thoughts

scientific article published on November 1989

Aging lowers steady-state antioxidant enzyme and stress protein expression in primary hepatocytes

scientific article

Alteration of ribosomal precursor RNA in Novikoff hepatoma cells by 5-azacytidine. Studies on methylation of 45S and 32S RNA.

scientific article published in December 1974

Alterations in enzymes of amino acid catabolism in livers of rats bearing the Morris 7800 hepatoma ⬇️

scientific article published on April 1, 1978

Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats

journal article published in 2004

Alterations in the maturation and structure of ribosomal precursor RNA in Novikoff hepatoma cells induced by 5-fluorocytidine

scientific article published on 01 June 1984

Altered hepatic foci: their role in murine hepatocarcinogenesis

scientific article published on January 1990

Amino acid-rich medium (Leibovitz L-15) enhances and prolongs proliferation of primary cultured rat hepatocytes in the absence of serum.

scientific article

An approach to the determination of the relative potencies of chemical agents during the stages of initiation and promotion in multistage hepatocarcinogenesis in the rat.

scientific article

An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver

scientific article

An energy-dependent activation of trypttophan pyrrolase

scientific article published on 01 June 1961

An enzymic study on the cellular origin of the DUNNING and the NOVIKOFF hepatomas in the rat ⬇️

scientific article

An examination of rat liver smooth endoplasmic reticulum membranes for the presence of associated messenger RNA

scientific article published on 01 December 1978

An improved stereologic method for three-dimensional estimation of particle size distribution from observations in two dimensions and its application

scientific article published in September 2003

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay

scientific article published on April 1991

An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma.

scientific article

Analbuminemic rats

scientific article published on July 1, 1992

Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.

scientific article published on 4 May 2017

Animal models of neoplastic development

scientific article published on 01 January 2001

Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver.

scientific article published in February 1982

Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver

scientific article published on April 1986

BIOCHEMICAL LESIONS IN MINIMAL DEVIATION HEPATOMAS

scientific article published on 01 January 1964

Biallelic expression of the H19 gene during spontaneous hepatocarcinogenesis in the albumin SV40 T antigen transgenic rat

scientific article published on 01 September 2003

Biochemical and immunologic studies on the native and deglycosylated forms of gamma-glutamyltranspeptidase of rat kidney

scientific article published in February 1986

Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine ⬇️

scientific article published on February 2, 1978

Biochemical events during initiation of rat hepatocarcinogenesis

scientific article published on 01 July 1994

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat ⬇️

scientific article published on June 1, 1991

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

scientific article published on 15 July 2005

Biological and Enzymatic Events in Chemical Carcinogenesis ⬇️

scientific article published on January 1, 1979

Biological markers characterizing the development of preneoplastic and neoplastic lesions in rodent liver

scientific article published on January 1987

Breast cancer

scientific article published on 01 January 1992

Building quantitative stereology data files with scion image, a public domain image processing and analysis software

scientific article

Cancer advisory board

scientific article published on 01 August 1982

Cancer and the environment: overview.

scientific article published in March 1980

Capecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant Breast and Bowel Project trial R-04

scientific article

Carbohydrate repression of enzyme induction in rat liver

scientific article published on 01 May 1963

Carcinogenesis and aging--two related phenomena? A review ⬇️

scientific article published on May 1, 1977

Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients ⬇️

scientific article published on April 1, 1993

Cathepsin T

scientific article

Cathepsin T (convertase) generates the multiple forms of tyrosine aminotransferase by limited proteolysis

scientific article published on 01 January 1982

Cell lines with heterogeneous phenotypes result from a single isolation of albumin-sv40 T-antigen transgenic rat hepatocytes

scientific article published on May 1997

Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein ⬇️

scientific article published on June 13, 2012

Changes in the DNA methylation profile of the rat H19 gene upstream region during development and transgenic hepatocarcinogenesis and its role in the imprinted transcriptional regulation of the H19 gene

scientific article

Characteristics of microsomal enzyme controls in primary cultures of rat hepatocytes ⬇️

scientific article published on January 1, 1979

Characteristics of small cell colonies developing in primary cultures of adult rat hepatocytes

scientific article published on 01 January 1992

Characteristics of the Carbohydrate Moiety and the Intermolecular Associations of the High-Molecular-Weight Forms of α2u-Globulin ⬇️

scientific article published on June 1, 1980

Characterization and sequence of a cDNA clone of gamma-glutamyltranspeptidase

scientific article

Characterization of a cytoplasmic histone-coenzyme A acetyltransferase

scientific article published on 01 November 1971

Characterization of a proteolipid complex of aminoacyl-tRNA synthetases and transfer RNA from rat liver ⬇️

scientific article published on May 24, 1979

Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine

scientific article published on 01 November 1974

Characterization of protein kinase activity associated with rat liver polysomal messenger ribonucleoprotein particles ⬇️

scientific article published on 01 July 1980

Characterization of radioactive immunochemically precipitated protein antigens using SDS-polyacrylamide gels ⬇️

scientific article published on 01 December 1971

Characterization of rarep53 mutants from carcinogen-treated albumin–simian virus 40 T-antigen transgenic rats ⬇️

scientific article published on February 1, 1998

Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rat ⬇️

scientific article published on January 1, 1991

Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months

scientific article published on 01 April 2000

Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat

scientific article published on August 1, 1992

Characterization of the rat Class 3 aldehyde dehydrogenase gene promoter

scientific article published on November 1996

Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens

scientific article published in August 1982

Chemicals and cancer: initiation and promotion

scientific article published on 01 July 1983

Chemicals, cell proliferation, risk estimation, and multistage carcinogenesis

scientific article published on January 1991

Cholangiocellular carcinomas induced in Syrian golden hamsters administered aflatoxin B1 in large doses

scientific article published on February 1, 1982

Chromatin structure of the c-myc gene in HL-60 cells during alterations of transcriptional activity

scientific article published on 01 October 1985

Class 3 aldehyde dehydrogenase. A northern perspective in the land down under.

scientific article published on January 1995

Cloning of DNA complementary to ornithine aminotransferase mRNA ⬇️

scientific article published on May 10, 1982

Co-induction of the hepatic amino acid transport system and tyrosine aminotransferase by theophylline, glucagon and dibutyryl-cyclic AMP in vivo

scientific article published on 01 October 1970

Colocalized alterations in connexin32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters

scientific article published on June 1994

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study

scientific article

Combination of paclitaxel and carboplatin as second-line therapy for patients with metastatic melanoma

scientific article

Comparative effects of actinomycin and ionizing radiation on enzyme synthesis in mammalian cells in vivo

scientific article

Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors

scientific article published in March 2002

Comparison of continuous versus categorical tumor measurement-based metrics to predict overall survival in cancer treatment trials

scientific article

Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis

scientific article published on September 1995

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion

scientific article

Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats ⬇️

scientific article published on November 1, 1995

Competitive DNA-RNA hybridization of microsomal and nuclear RNA in normal tissues of the rat

scientific article published on October 1, 1973

Competitive DNA-RNA hybridization of nuclear and microsomal RNA in normal, neoplastic, and neonatal liver tissue

scientific article published on 01 October 1973

Competitive RNA-DNA hybridization of nuclear and microsomal RNA during diethylnitrosamine hepatocarcinogenesis.

scientific article published in July 1973

Consequences of altered poly(ADP-ribose) metabolism on hepatocyte functions in vitro

scientific article published on 01 January 1983

Contribution of the Morris Hepatomas to the Biochemistry of Cancer — Establishment of the Phenotypic Heterogeneity of Neoplasms In Vivo ⬇️

scientific article published on May 22, 1977

Control Mechanisms in the Normal and Neoplastic Cell* ⬇️

scientific article published on January 1965

Control of biochemical expression in morphologically related cells in vivo and in vitro

scientific article

Correlation of rat liver membrane binding of polysomes in vitro with function of the complexes formed

scientific article published on 01 January 1973

CpG PatternFinder: a Windows-based utility program for easy and rapid identification of the CpG methylation status of DNA.

scientific article published in September 2007

CpG analyzer, a Windows-based utility program for investigation of DNA methylation

scientific article published on 01 November 2005

Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat.

scientific article published on January 1989

Crystal Structure of Serine Dehydratase from Rat Liver, ⬇️

scientific article published on November 11, 2003

Cyclic adenosine 3',5'-monophosphate during glucose repression in the rat liver

scientific article published on 01 October 1971

Cyclic nucleotide binding sites of the smooth endoplasmic reticulum from normal and neoplastic liver in the rat ⬇️

scientific article published on November 1, 1975

Cystic fibrosis. A dilemma in the metabolic pathogenesis of genetic disease

scientific article published on January 1, 1976

Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes

scientific article published on 01 September 1976

Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression

scientific article published on July 1996

DNA Damage and Repair in - Glutamyltranspeptidase-Positive and Negative Hepatocytes in Primary Culture from Carcinogen-Treated Rats

scientific article published on January 1, 1991

DNA damage induced by the antihistaminic drug methapyrilene hydrochloride

scientific article published on 01 March 1982

Decay of cytoplasmic polyadenylated RNA's labeled with [3H]orotate in rat liver and the effect of the re-utilization of labeled precursor on such decay

scientific article published on June 28, 1977

Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer

scientific article

Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment

scientific article published on 01 September 1978

Dependence of the induction of cytochrome P-450 by phenobarbital in primary cultures of adult rat hepatocytes on the composition of the culture medium

scientific article published on 01 July 1989

Determining the affinity in vitro of hepatic ribosomal subunits for derivatives of the rough endoplasmic reticulum

scientific article published on 01 September 1973

Diamine oxidase activity in fibroblasts from normal and cystic fibrosis patients

scientific article published on 01 February 1980

Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.

scientific article published on January 1988

Dietary induction of some enzymes of amino acid metaboli during azo dye feeding

scientific article published on 01 February 1969

Dietary induction of some enzymes of amino acid metabolism during 2-acetylaminofluorene feeding

scientific article published on 01 February 1969

Dietary induction of some enzymes of amino acid metabolism following the acute administration of aminoazo dyes

scientific article published on 01 July 1970

Dietary induction of some enzymes of carbohydrate metabolism during 2-acetylaminofluorene feeding

scientific article published on 01 February 1969

Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation

scientific article published on 01 January 1999

Differences in the expression of connexin genes in rat hepatomas in vivo and in vitro

scientific article published on 01 November 1994

Differential gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Noncoordinate regulation of a TCDD-induced aldehyde dehydrogenase and cytochrome P-450c in the rat

scientific article published on 01 August 1988

Direct association of messenger RNA labeled in the presence of fluoroorotate with membranes of the endoplasmic reticulum in rat liver ⬇️

scientific article published on July 1, 1976

Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice

scientific article published on 11 June 2009

Diurnal variation of the serine dehydratase mRNA level in rat liver

scientific article published on 01 January 1994

Dominant role of HPV16 E7 in anal carcinogenesis ⬇️

scientific article published on October 13, 2011

Dr. Elizabeth C. Miller (1920-1987).

scientific article published on February 1988

Drug metabolism and effects of carcinogens in cultured hepatic cells ⬇️

scientific article published on September 1, 1979

E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice

scientific article

ENDOPLASMIC RETICULUM AND HEPATIC CARCINOGENESIS

scientific article

Effect of 5-fluoroorotic acid administration of the 32 P base composition, DNA-RNA hybridization properties, and labeling of polyadenylate-rich RNA in the cytoplasm of rat liver cells

scientific article published on 01 April 1973

Effect of Chronic Administration of Mestranol, Tamoxifen, and Toremifene on Hepatic Ploidy in Rats ⬇️

scientific article published on June 1, 1998

Effect of Gamma Radiation on Dietary and Hormonal Induction of Enzymes in Rat Liver ⬇️

scientific article published on 01 November 1965

Effect of age on the formation of small-cell colonies in cultures of primary rat hepatocytes

scientific article published on 01 July 1993

Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats ⬇️

scientific article published on June 1, 1991

Effect of hypolipidemic peroxisome proliferators on unscheduled DNA synthesis in cultured hepatocytes and on mutagenesis in Salmonella

scientific article published in September 1984

Effect of ribosome removal of rough microsomal composition and polysome attachment in vitro. Comparison of liver and kidney.

scientific article

Effect of the Inhibition of RNA Synthesis on in vitro Ovulation by Frog Ovaries ⬇️

scientific article published on 01 July 1969

Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats

scientific article published on 01 August 1989

Effect of the peroxisome proliferator perfluorodecanoic acid on the promotion of two-stage hepatocarcinogenesis in rats

scientific article published on 01 August 1993

Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.

scientific article

Effects of 5-azacytidine on dietary and hormone induction of serine dehydratase and tyrosine aminotransferase in rat liver

scientific article published on 01 October 1972

Effects of 5-azacytidine on hepatic polyribosomes and maturation of ribosomal RNA.

scientific article published on January 1974

Effects of 5-azacytidine on nucleolar RNA and the preribosomal particles in Novikoff hepatoma cells

scientific article

Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes

scientific article published on 01 November 1982

Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus

scientific article published in April 1997

Effects of extracellular matrix components on the growth and differentiation of cultured rat hepatocytes

scientific article published on 01 April 1987

Effects of glucose, insulin, and cAMP on transcription of the serine dehydratase gene in rat liver

scientific article

Effects of phenobarbital on I-compounds in liver DNA as a function of age in male rats fed two different diets ⬇️

scientific article published on January 1, 1992

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver

scientific article published on 01 April 1995

Effects of the Antiestrogens Tamoxifen, Toremifene, and ICI 182,780 on Endometrial Cancer Growth ⬇️

scientific article published on October 21, 1998

Effects of tumor-promoting agents 12-O-tetradecanoylphorbol-13-acetate and phenobarbital on DNA synthesis of rat hepatocytes in primary culture

scientific article published in November 1987

Efficacy of CPT-11 (irinotecan) as a single agent in metastatic colorectal cancer

scientific article

Electron microscopic and time lapse studies of mitosis in cultured rat hepatocytes

scientific article published on 01 November 1988

Endogenous carcinogenesis: the role of tumor promotion

scientific article

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia

scientific article

Endoplasmic reticulum and phenotypic variability in normal and neoplastic liver.

scientific article

Enhanced efficacy of anti-VEGFR2/taxane therapy after progression on immune checkpoint inhibition (ICI) in patients (pts) with metastatic gastroesophageal adenocarcinoma (mGEA).

scientific article published on 04 February 2020

Enhanced efficacy of anti-VEGFR2/taxane therapy after progression on immune checkpoint inhibition (ICI) in patients (pts) with metastatic gastroesophageal adenocarcinoma (mGEA).

scientific article published on 25 May 2020

Environmental effects on glutathione-insulin transhydrogenase in rat liver ⬇️

scientific article published on 01 September 1976

Environmental modifiers in carcinogenesis

scientific article published in January 1982

Enzymatic and biochemical properties of a novel human serine dehydratase isoform

scientific article published on 20 March 2006

Enzyme levels in rats adapted to 36-hour fasting

scientific article

Enzymes of carbohydrate and amino acid metabolism in liver, brain and kidney of Macaca mulatta

scientific article published in September 1971

Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis

scientific article published on January 1987

Enzymology of Highly Differentiated Hepatocellular Carcinomas1 ⬇️

scientific article published on January 1, 1976

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice

scientific article

Evidence for bile acid synthesis by transplantable hepatomas.

scientific article published in July 1974

Examination of glycosylated alpha 2u-globulin-containing medium for steroid-binding activity

scientific article published on 01 July 1980

Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine

scientific article published on 01 May 1986

Expression of albumin messenger RNA detected by in situ hybridization in preneoplastic and neoplastic lesions in rat liver

scientific article

Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital

scientific article published on November 1995

Expression of the c-raf protooncogene, gamma-glutamyltranspeptidase, and gap junction protein in rat liver neoplasms

scientific article published on 01 March 1988

Extra-hepatic hepatocellular carcinoma presenting as obstructive jaundice

scientific article published on 19 October 2005

Extracellular matrix components influence DNA synthesis of rat hepatocytes in primary culture

scientific article published on 01 December 1986

Factors predisposing to cancer

scientific article published on 01 July 1981

Facts and theories concerning the mechanisms of carcinogenesis ⬇️

scientific article published on June 1, 1991

Falls: descriptive rates and circumstances in age-unspecified patients with locally advanced esophageal cancer

scientific article published on 24 May 2020

Fatal cicatricial mucous membrane pemphigoid of the trachea

scientific article published on 01 July 1962

Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of trytophan pyrrolase activity.

scientific article

Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes ⬇️

scientific article published on January 1, 1979

Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741

scientific article

Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats

scientific article

Functional studies of polysome-membrane interactions in vitro

scientific article

Future directions in adjuvant therapy for stage III colon carcinoma.

scientific article

Gamma-glutamyl transpeptidase--its role in hepatocarcinogenesis

scientific article published on February 1985

Gemcitabine and oxaliplatin for metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II study.

scientific article

Gemcitabine and oxaliplatin for patients with advanced or metastatic pancreatic cancer: a North Central Cancer Treatment Group (NCCTG) phase I study

scientific article

Gene expression during multistage hepatocarcinogenesis

scientific article published on 01 January 1988

Genes, chromosome loci and disease

scientific article published on 01 December 1975

Genetics and epigenetics of neoplasia: facts and theories

scientific article

Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.

scientific article

Glucocorticoids stimulate CREB binding to a cyclic-AMP response element in the rat serine dehydratase gene

scientific article

Glucose repression and induction of enzyme synthesis in rat liver

scientific article published on 01 January 1964

Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital

scientific article published on 01 December 1985

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO

scientific article published in April 1964

Hazard assessment of chemical carcinogens: the impact of hormesis.

scientific article

Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene ⬇️

scientific article published on January 1, 1982

Hepatocarcinogenesis as a Problem in Developmental Biology ⬇️

scientific article published on January 1, 1980

Hepatocarcinogenicity of Estragole (1-Allyl-4-methoxybenzene) and 1′-Hydroxyestragole in the Mouse and Mutagenicity of 1′-Acetoxyestragole in Bacteria 2 ⬇️

scientific article (publication date: December 1976)

Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of lgf2 and deregulation of H19.

scientific article published in September 2007

Hepatocyte death in hepatocarcinogenesis ⬇️

scientific article published on 01 July 1998

High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins

scientific article

Hormonal Regulation of Phosphoenolpyruvate Carboxykinase in Primary Cultures of Adult-Rat Liver Parenchymal Cells ⬇️

scientific article published on June 15, 1978

Hormonal and developmental regulation of glycosylated α2u-globulin synthesis ⬇️

scientific article published on May 1, 1980

Hormonal and nutritional effects on the binding of 125I-labeled anti-serine dehydratase Fab' to rat tissue polysomes

scientific article published on August 10, 1976

Hormonal effects on enzyme activities in tissue culture and in whole animals

scientific article published in January 1967

Hormonal regulation and the effects of glucose on tyrosine aminotransferase activity in adult rat hepatocytes cultured on floating collagen membranes ⬇️

scientific article published on June 1, 1978

Hormonal regulation of glucokinase in primary cultures of adult rat hepatocytes ⬇️

scientific article published on December 25, 1979

Hormonal regulation of ornithine aminotransferase biosynthesis in rat liver and kidney ⬇️

scientific article published on April 30, 1977

Hormonal regulation of serine dehydratase gene expression in liver and kidney of the adrenalectomized rat

scientific article published on 01 November 1991

Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat.

scientific article

Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources

scientific article

Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis

scientific article

Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice

scientific article published on 24 August 2010

Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP-positive liver neoplasms ⬇️

scientific article published on 01 August 1998

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model

scholarly article

Identification of regions in the rat serine dehydratase gene responsible for regulation by cyclic AMP alone and in the presence of glucocorticoids

scientific article published on December 1992

Immunohistochemical demonstration of serine dehydratase in rat liver ⬇️

scientific article published on February 1, 1975

Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen

scientific article

Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741.

scientific article

Implications of hormesis on the bioassay and hazard assessment of chemical carcinogens ⬇️

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Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase ⬇️

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In vitro synthesis and processing of a precursor to ornithine aminotransferase ⬇️

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Inability of red beet betalain pigments to initiate or promote hepatocarcinogenesis

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Incidental findings in imaging research: evaluating incidence, benefit, and burden

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Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis

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Incorporation of label from 5-fluoroorotate into non-ribosomal cytoplasmic RNA in rat liver

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Increase of l-serine dehydratase activity under gluconeogenic conditions in adult-rat hepatocytes cultured on collagen gel/nylon mesh ⬇️

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Increased activities of liver cathepsins T and D in carbon tetrachloride-treated rats

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Induction of a previously non-inducible enzyme in Morris hepatoma 9618A

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Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine

scientific article published in September 1986

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats

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Induction of lipogenic enzymes in primary cultures of rat hepatocytes. Relationship between lipogenesis and carbohydrate metabolism

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Influence of background genome on enzymatic characteristics of yellow (A v -, A vy -) mice

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Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats

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Inhibition of Ribosomal Ribonucleic Acid Maturation in Rat Liver by 5-Fluoroorotic Acid Resulting in the Selective Labeling of Cytoplasmic Messenger Ribonucleic Acid ⬇️

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Inhibition of cyclic AMP-dependent induction of ornithine aminotransferase by simple carbohydrates in cultured hepatocytes

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Inhibition of ribosomal RNA maturation in Novikoff hepatoma cells by toyocamycin, tubercidin, and 6-thioguanosine

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Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells

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Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine

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Interaction of chemical carcinogens and drug-metabolizing enzymes in primary cultures of hepatic cells from the rat ⬇️

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Interaction of glucagon and catecholamines in the regulation of serine dehydratase

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Interactions in the natural history of aging and carcinogenesis

scientific article published on 01 December 1978

Interactive cytogenetic effects on rat bone-marrow due to chronic ingestion of 2,5,2',5' and 3,4,3',4' PCBs

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Interrelationships of mammalian hormones and enzyme levels in vivo ⬇️

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Intratumoral administration of a 1,2-dimyristyloxypropyl-3- dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine formulation of the human interleukin-2 gene in the treatment of metastatic renal cell carcinoma

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Isolation and characterization of rat liver free and membrane-bound polysomal messenger ribonucleoprotein particles

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Isolation and characterization of the rat gene encoding ornithine aminotransferase

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Isolation and fractionation of ribonucleic acid from the smooth endoplasmic reticulum of rat liver

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Isolation and nucleotide sequence of the cDNA for rat liver serine dehydratase mRNA and structures of the 5' and 3' flanking regions of the serine dehydratase gene

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Isolation of γ-glutamyl transpeptidase positive hepatocytes during the early stages of hepatocarcinogenesis in the rat ⬇️

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Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat

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L-tryptophan inhibition of tyrosine aminotransferase degradation in rat liver in vivo

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Labeling of cytoplasmic liver RNA by (6- 14 C)orotic and 5-fluoro(2- 14 C)orotic acids. Effect of several inhibitors.

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Lack of acetylaminofluorene--DNA adduct formation in enzyme-altered foci of rat liver

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Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators

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Levels of ornithine aminotransferase messenger RNA under conditions of cyclic AMP induction in cultured hepatocytes

scientific article published on September 1985

Limited sampling models for CPT-11, SN-38, and SN-38 glucuronide

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Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors

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Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney

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Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway

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Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice

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METABOLIC ADAPTATIONS IN RAT HEPATOMAS. VI. SUBSTRATE-HORMONE RELATIONSHIPS IN TRYPTOPHAN PYRROLASE INDUCTION

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METABOLIC REGULATORY CIRCUITS AND CARCINOGENESIS

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Maintenance of glucokinase activity in primary hepatocyte cultures

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Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes

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Mammary tumor induction in transgenic mice expressing an RNA-binding protein

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Mechanisms in cellular metabolic regulation

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Medium term effects of a new 5HT3 antagonist, alosetron, in patients with carcinoid diarrhoea ⬇️

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Metabolic adaptations and the neoplastic cell

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Metabolic adaptations during hepatocarcinogenesis: dietary induction of some enzymes of carbohydrate metabolism during 3'-methyl- and 2-methyl-N,N-dimethyl-4-aminoazobenzene feeding

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Metabolic adaptations in rat hepatomas. I. The effect of dietary protein on some inducible enzymes in liver and hepatoma 5123

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Metabolic adaptations in rat hepatomas. II. Tryptophan pyrrolase and tyrosine alpha-ketoglutarate transaminase

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Metabolic adaptations in rat hepatomas. III. Glucose-phosphate dehydrogenase and pyrimidine reductases

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Metabolic adaptations in rat hepatomas. IV. Regulation of threonine and serine dehydrase

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Metabolic adaptations in rat hepatomas. V. Reciprocal relationship between threonine dehydrase and glucose-6-phosphate dehydrogenase

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Metabolic adaptations in rat hepatomas: altered regulation of serine dehydratase synthesis by glucose and amino acids in hepatocellular carcinomas.

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Metabolic adaptations in rat hepatomas: some properties of apo-tryptophan pyrrolase of rat liver and two hepatocellular carcinomas

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Methodology and utility of primary cultures of hepatocytes from experimental animals

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Microfilament accumulation and the transport of amino acids and glucose in adult rat hepatocytes cultured on collagen gel/nylon mesh

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Models of hepatocarcinogenesis in the rat--contrasts and comparisons

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Modulation of c-myc expression in the HL-60 cell line

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Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver

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Molecular pathogenesis of experimental liver cancer

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Mucinous appendiceal adenocarcinoma presenting 5 years after appendectomy

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Multidisciplinary graduate training for biomedical science

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Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor ⬇️

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Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.

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Multiple polypeptide hormone expression in pancreatic islet cell carcinomas derived from phosphoenolpyruvatecarboxykinase-SV40 T antigen transgenic rats

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Multistage carcinogenesis--genetic and epigenetic mechanisms in relation to cancer prevention

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Multistage carcinogenesis: the Twenty-Second International Symposium of the Princess Takamatsu Cancer Research Fund ⬇️

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Multistage hepatocarcinogenesis in the rat: insights into risk estimation

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Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis.

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N-hydroxy metabolites of 2-acetylaminophenanthrene and 7-fluoro-2-acetylaminofluorene as proximate carcinogens in the rat

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N-terminal acetylation of histone-like nascent peptides on rat liver polyribosomes in vitro

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Nakahara Memorial Lecture. Pathways of carcinogenesis--genetic and epigenetic

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Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial

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Neoplasia: a somatic mutation or a heritable change in cytoplasmic membranes?

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New discoveries in oncology: potential applications to clinical practice

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Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver

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Nuclear-labeling index analysis (NLIA), a software package used to perform accurate automation of cell nuclear-labeling index analysis on immunohistochemically stained rat liver samples

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Number of ouabain-binding sites in fibroblasts from normal subjects and patients with cystic fibrosis

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Nutritional regulation and tissue-specific expression of the serine dehydratase gene in rat.

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O-phosphorylethanolamine ammonia lyase, a new pyridoxal phosphate-dependent enzyme ⬇️

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Octreotide inhibition of flushing and colonic motor dysfunction in carcinoid syndrome

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On the passing of Gerald C. Mueller, MD, PhD (1920–2010).

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Oncogenes and human neoplasia

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Optimum doses of irinotecan

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Osteoporotic bone disease in the pyridoxine-deficient rat

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Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats

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Oxaloacetate induces DNA synthesis and mitosis in primary cultured rat hepatocytes in the absence of EGF

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Pathology of mouse models of intestinal cancer: consensus report and recommendations

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Pathways of progression in hepatocarcinogenesis

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Peptide vaccination of patients with metastatic melanoma: improved clinical outcome in patients demonstrating effective immunization

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Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

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Phase 1b/II study of cancer stemness inhibitor napabucasin in combination with FOLFIRI +/- bevacizumab (bev) in metastatic colorectal cancer (mCRC) patients (pts)

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Phase 2 study of bevacizumab plus erlotinib in patients with advanced hepatocellular cancer ⬇️

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Phase I and pharmacokinetic study of irinotecan and docetaxel in patients with advanced solid tumors: preliminary evidence of clinical activity

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Phase I and pharmacokinetic study of two different schedules of oxaliplatin, irinotecan, Fluorouracil, and leucovorin in patients with solid tumors

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Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors

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Phase I dose-finding and pharmacokinetic trial of irinotecan hydrochloride (CPT-11) using a once-every-three-week dosing schedule for patients with advanced solid tumor malignancy.

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Phase I evaluation of preirradiation chemotherapy with carmustine and cisplatin and accelerated radiation therapy in patients with high-grade gliomas.

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Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7 ⬇️

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Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566.

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Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors

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Phase I trial of gemcitabine and CPT-11 given weekly for four weeks every six weeks

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Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).

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Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer

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Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen

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Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer

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Phase II study of erlotinib in patients with advanced biliary cancer

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Phase II trial of irinotecan in patients with metastatic colorectal carcinoma ⬇️

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Phase III clinical trial of the combination of cisplatin, dacarbazine, and carmustine with or without tamoxifen in patients with advanced malignant melanoma

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Phase III noninferiority trial comparing irinotecan with oxaliplatin, fluorouracil, and leucovorin in patients with advanced colorectal carcinoma previously treated with fluorouracil: N9841.

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Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats

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Pilot study of continuous-infusion 5-fluorouracil, oral leucovorin, and upper-abdominal radiation therapy in patients with locally advanced residual or recurrent upper gastrointestinal or extrapelvic colon cancer

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Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741.

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Ploidy and karyotype of hepatocytes isolated from enzyme-altered foci in two different protocols of multistage hepatocarcinogenesis in the rat.

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Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver

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Pocket Proteins Suppress Head and Neck Cancer ⬇️

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Polyadenylate-containing RNA of polyribosomes isolated from rat liver and Morris hepatoma 7800

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Polyamine degradation in foetal and adult bovine serum

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Polyribosomal attachment to rat liver and hepatoma endoplasmic reticulum in vitro. A method for its study

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Polysome interaction in vitro with smooth microsomal membranes from rat liver ⬇️

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Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide

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Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17.

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Preliminary characterization of the rat class 3 aldehyde dehydrogenase gene.

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Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma

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Preparation of ribonuclease-free DNase I and -amylase

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Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations

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Priming tissue-specific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancer.

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Progression: the terminal stage in carcinogenesis

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Prolien synthesis and degradation in a minimal deviation hepatoma ⬇️

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Proliferation-associated differences in the spatial and temporal expression of gap junction genes in rat liver ⬇️

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Promotion by dietary phenobarbital of hepatocarcinogenesis by 2-methyl-N,N-dimethyl-4-aminoazobenzene in the rat ⬇️

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Properties of incomplete carcinogens and promoters in hepatocarcinogenesis

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Protein Degradation in Normal and Beige (Chediak-Higashi) Mice ⬇️

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Protein Phosphorylation of the Smooth and Rough Endoplasmic Reticulum in Normal and Neoplastic Liver of the Rat ⬇️

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Protein acetylation

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Protein synthesis on rat liver polysome-membrane complexes formed in vitro and disposition of the discharges chains

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Protein turnover in microsomal subfractions of liver and Morris hepatomas 7800 and 9618A

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Proto-oncogene activation during chemically induced hepatocarcinogenesis in rodents

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Proto-oncogene activation in multistage murine hepatocarcinogenesis

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Purification and characterization of a factor catalyzing the conversion of the multiple forms of tyrosine aminotransferase from rat liver ⬇️

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Purification and characterization of a new thiol proteinase from rat kidney

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Putrescine-oxidase activity in adult bovine serum and fetal bovine serum ⬇️

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Quantitation of multistage carcinogenesis in rat liver

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Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats

scientific article published in October 1999

Quantitative analysis of the time-dependent development of glucose-6-phosphatase-deficient foci in the livers of mice treated neonatally with diethylnitrosamine

scientific article published on 01 May 1981

Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.

scientific article published in February 1993

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine

scientific article published on 01 October 1980

Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis

scientific article published in February 1990

Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers

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Quantitative stereological evaluation of four histochemical markers of altered foci in multistage hepatocarcinogenesis in the rat.

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Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats

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Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Tri

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Rapamycin inhibits anal carcinogenesis in two preclinical animal models

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Rapid uptake of dietary cholesterol by hyperplastic liver nodules and primary hepatomas

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Rat liver and hepatoma polysome-membrane interaction in vitro

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Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis

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Rat serine dehydratase gene codes for two species of mRNA of which only one is translated into serine dehydratase

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Recent advances in the mechanism of hepatic carcinogenesis

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Reestablishment of cell polarity of rat hepatocytes in primary culture

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Regression of metastatic carcinoid tumor after valvular surgery for carcinoid heart disease

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Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase in hepatoma cells

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Regulation of ATP-citrate lyase in primary cultures of adult rat hepatocytes ⬇️

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Regulation of gene expression in primary cultures of adult rat hepatocytes on collagen gels ⬇️

scientific article published on January 1, 1980

Regulation of ornithine aminotransferase by cyclic AMP and glucose in primary cultures of adult rat hepatocytes

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Regulation of ornithine aminotransferase mRNA levels in rat kidney by estrogen and thyroid hormone ⬇️

scientific article published on February 10, 1983

Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.

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Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat

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Regulation of the synthesis of serine dehydratase isozymes

scientific article published on 01 January 1970

Regulatory effects of nicotinamide on tryptophan pyrrolase synthesis in rat liver in vivo

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Regulatory elements for the tissue-specific expression of the rat serine dehydratase-encoding gene

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Relation between fat malabsorption and transit abnormalities in human carcinoid diarrhea

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Relationships of bioassay data on chemicals to their toxic and carcinogenic risk for humans

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Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study

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Response of hepatic enzyme activities to castration and sarcoma 37 growth in different mouse genotypes

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Response of several hepatic adaptive enzymes to a shift from low to high protein diet in intact and adrenalectomized rats.

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Reversal by aminoguanidine of the inhibition of proliferation of human fibroblasts by spermidine and spermine ⬇️

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Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation

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Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease

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Ribonuclease activity of pancreatic extracts

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Role of Ultraviolet Radiation in Papillomavirus-Induced Disease

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Role of altered hepatic foci in the stages of carcinogenesis

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Role of insulin, glucose, and cyclic GMP in the regulation of glucokinase in cultured hepatocytes

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SOME BIOCHEMICAL ESSENTIALS OF MALIGNANCY.

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STEREO: A program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents ⬇️

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STUDIES ON THE INDUCTION AND REPRESSION OF ENZYMES IN RAT LIVER. 3. INDUCTION OF ORNITHINE DELTA-TRANSAMINASE AND THREONINE DEHYDRASE BY ORAL INTUBATION OF FREE AMINO ACIDS

scientific article published in July 1965

STUDIES ON THE INDUCTION AND REPRESSION OF ENZYMES IN RAT LIVER. I. INDUCTION OF THREONINE DEHYDRASE AND ORNITHINE-DELTA-TRANSAMINASE BY ORAL INTUBATION OF CASEIN HYDROLYSATE

scientific article published on 01 June 1964

STUDIES ON THE INDUCTION AND REPRESSION OF ENZYMES IN RAT LIVER. II. CARBOHYDRATE REPRESSION OF DIETARY AND HORMONAL INDUCTION OF THREONINE DEHYDRASE AND ORNITHINE DELTA-TRANSAMINASE

scientific article published on 01 December 1964

SUBSTRATE AND HORMONAL INTERACTIONS IN THE REGULATION OF ENZYME LEVELS IN RAT HEPATOMAS

scientific article published on 01 January 1963

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

scientific article (publication date: 28 June 2012)

Safety and activity of temsirolimus and bevacizumab in patients with advanced renal cell carcinoma previously treated with tyrosine kinase inhibitors: a phase 2 consortium study

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Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study.

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Selective loss of nucleoside carrier expression in rat hepatocarcinomas.

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Separation of putrescine oxidase and spermidine oxidase in foetal bovine serum with the aid of a specific radioactive assay of spermidine oxidase

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Sequence of the precursor to rat ornithine aminotransferase deduced from a cDNA clone

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Sequence of the rat serine dehydratase gene

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Serum ribonuclease levels in patients with cystic fibrosis

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Short-term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: role of cell replication, apoptosis, and gene expression

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Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor

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Sodium butyrate preserves aspects of the differentiated phenotype of normal adult rat hepatocytes in culture

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Some aspects of the developmental biology of neoplasia

scientific article published in September 1968

Some biochemical and histochemical properties of human liver serine dehydratase

scientific article published in March 2005

Some enzyme patterns of Morris hepatoma 9618A under controlled feeding schedules

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Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms ⬇️

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Specific gene expression during compensatory renal hypertrophy in the rat

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Spermidine oxidase in human pregnancy serum. Probable identity with diamine oxidase

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Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.

scientific article published in March 1996

Stage of tumor progression, progressor agents, and human risk

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Stage-specific gene expression during hepatocarcinogenesis in the rat.

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Static and dynamic aspects of amino acid pools in rat liver and Morris hepatomas 9618A and 7800

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Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by sodium butyrate

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Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase

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Structure and function of rat liver polysome populations. I. Complexity, frequency distribution, and degree of uniqueness of free and membrane-bound polysomal polyadenylate-containing RNA populations

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Structure and function of rat liver polysome populations. II. Characterization of polyadenylate-containing mRNA associated with subpopulations of membrane-bound particles

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Structure of the 5' flanking region of class 3 aldehyde dehydrogenase in the rat.

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Structure–Activity Relationships for Triphenylethylene Antiestrogens on Hepatic Phase-I and Phase-II Enzyme Expression ⬇️

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Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats

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Studies on a 32S component of nuclear RNA.

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Studies on basic charged molecules and cell membranes in cystic fibrosis

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Studies on the Mechanism of Enzyme Induction in Rat Liver ⬇️

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Studies on the conversion of multiple forms of tyrosine aminotransferase in rat liver ⬇️

scientific article published on November 1, 1976

Studies on the induction and repression of enzymes in rat liver. Characteristics of the L-tryptophan and cortisone-mediated induction of serine dehydratase in the livers of intact and adrenalectomized rats

scientific article published on 01 January 1975

Studies on the induction and repression of enzymes in rat liver. Characterization and metabolic regulation of multiple forms of tyrosine aminotransferase

scientific article published on 01 April 1973

Studies on the induction and repression of enzymes in rat liver. IV. Effects of cortisone and phenobarbital

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Studies on the induction and repression of enzymes in rat liver. V. Regulation of the rate of synthesis and degradation of serine dehydratase by dietary amino acids and glucose

scientific article published in June 1968

Studies on the induction and repression of enzymes in rat liver. VI. Some properties and the metabolic regulation of two isozymic forms of serine dehydratase

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Studies on the mechanism of 5-fluoroorotic acid inhibition of serine dehydratase induction

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Studies on the mechanism of carbohydrate repression in rat liver

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Studies on the mechanism of template stability. I. The effect of actinomycin on the base composition and sedimentation of 32P-labeled RNA in rat liver

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Studies on the mechanism of template stability: cytoplasmic DNA-like RNA in hepatocellular carcinomas

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Studies on the mechanism of the stimulation of tyrosine aminotransferase activity in vivo by pyrimidine analogs: the role of enzyme synthesis and degradation

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Studies on the role of adenosine 3',5'-monophosphate during glucose repression in rat liver

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Studies on the synthesis of plasma membrane proteins of fibroblasts from patients with cystic fibrosis ⬇️

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Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo

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Superinduction of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase by the inhibition of protein synthesis

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Survey of some enzyme patterns in transplantable Reuber mouse hepatomas.

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Symposium: Cell-carcinogen interaction in tissue culture. Introduction ⬇️

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Systematic oscillations in metabolic activity in rat liver and hepatomas. Survey of normal diploid and other hepatoma lines.

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Systematic oscillations in metabolic activity in rat liver and hepatomas: effect of hydrocortisone, glucagon, and adrenalectomy on diploid and other hepatoma lines

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Systematic oscillations in metabolic activity in rat liver and in hepatomas. I. Morris hepatoma No. 7793

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Systematic oscillations in tyrosine transaminase and other metabolic functions in liver of normal and adrenalectomized rats on controlled feeding schedules

scientific article published in June 1968

THE AUTOMATED ASSAY OF COMPLETE ENZYME REACTION RATES. I. METHODS AND RESULTS

scientific article published on 01 December 1964

Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats

scientific article published in July 1994

Template stability of some enzymes in rat liver and hepatoma

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Teratogenic effects of 5-bromodexyuridine on the external morphology of Drosophila melanogaster

scientific article published in April 1973

The McArdle Laboratory for Cancer Research

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The McArdle Laboratory for Cancer Research: the first fifty years

scientific article published on 01 January 1990

The Membron: A Functional Hypothesis for the Translational Regulation of Genetic Expression ⬇️

scientific article published on January 1, 1974

The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse ⬇️

scientific article published on September 1, 1979

The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse.

scientific article published on 8 December 2004

The association in vitro of polyribosomes with ribonuclease-treated derivatives of hepatic rough endoplasmic reticulum. Characteristics of the membrane binding sites and factors influencing association ⬇️

scientific article published on November 1, 1971

The automated assay of complete enzyme reaction rates. II. Digital readout and data processing of linear rates

scientific article published on March 1968

The bicarbonate ion is essential for efficient DNA synthesis by primary cultured rat hepatocytes

scientific article published on 01 July 1991

The binding of cyclic nucleotides to membranes of the endoplasmic reticulum of normal and neoplastic rat liver ⬇️

scientific article published on July 1, 1976

The biochemical morphology and morphogenesis of hepatomas.

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The comparative enzymology and cell origin of rat hepatomas. I. Deoxycytidylate deaminase and thymine degradation

scientific article published on 01 September 1960

The comparative enzymology and cell origin of rat hepatomas. II. Glutamate dehydrogenase, choline oxidase, and glucose-6-phosphatase

scientific article published on 01 September 1960

The comparative enzymology and cell origin of rat hepatomas. III. Some enzymes of amino acid metabolism

scientific article published on 01 January 1963

The control of DNA synthesis in primary cultures of hepatocytes from adult and young rats: interactions of extracellular matrix components, epidermal growth factor, and the cell cycle

scientific article published on 01 February 1987

The effect of amino acid composition of serum-free medium on DNA synthesis in primary hepatocyte cultures in the presence of epidermal growth factor

scientific article published on 01 December 1995

The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver

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The effect of gamma radiation and actinomycin on cortisone induction of liver enzymes

scientific article published on 01 April 1972

The effect of nicotinamide on unscheduled DNA synthesis in cultured hepatocytes

scientific article published on 01 August 1980

The effect of pyrimidine analogues and tryptophan on enzyme synthesis and degradation in rat liver

scientific article published in January 1970

The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage ⬇️

scientific article published on August 1, 1998

The effect of sodium butyrate on tyrosine aminotransferase induction in primary cultures of normal adult rat hepatocytes

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The effect of spermidine and spermine on proliferation in vitro of fibroblasts from normal and cystic fibrosis patients

scientific article published on 01 May 1976

The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

scientific article published on March 1996

The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats

scientific article published in March 1993

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine

scientific article published in June 1991

The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: the role of apoptosis and cell proliferation

scientific article published in January 1997

The effect of various treatments in vitro and in vivo on the binding of 125I-labeled anti-rat serum albumin Fab' to rat tissue polyribosomes

scientific article published on August 10, 1976

The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.

scientific article

The expression and metabolic activity of cytochrome P-450 isozymes in control and phenobarbital-induced primary cultures of rat hepatocytes

scientific article published on 01 May 1988

The expression of the myc proto-oncogene in a dimethylsulfoxide resistant HL-60 cell line

scientific article published in February 1984

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals

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The in vitro synthesis of protein

scientific article published on 01 August 1955

The initiation-promotion-progression model of rat hepatocarcinogenesis

scientific article published on January 1993

The instability of tumor promotion in relation to human cancer risk

scientific article published on January 1995

The interaction of external and internal controls on enzyme levels and hepatoma.

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The interconversion of multiple forms of tyrosine aminotransferase

scientific article published on July 1975

The interconversion of multiple forms of tyrosine aminotransferase ⬇️

scientific article published on July 22, 1975

The mechanism of thioacetamide-induced apoptosis in the L37 albumin-SV40 T-antigen transgenic rat hepatocyte-derived cell line occurs without DNA fragmentation ⬇️

scientific article published on October 1, 1998

The metabolism of O-phosphorylethanolamine in animal tissues. I. O-phosphorylethanolamine phospho-lyase: partial purification and characterization

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The metabolism of O-phosphorylethanolamine in animal tissues. II. Metabolic regulation of O-phosphorylethanolamine phospho-lyase in vivo.

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The molecular biology of carcinogenesis

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The molecular determinants of carcinogenesis

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The multistage nature of chemically induced hepatocarcinogenesis in the rat.

scientific article published on January 1994

The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration

scientific article published on 01 January 1984

The natural history of carcinogenesis: implications of experimental carcinogenesis in the genesis of human cancer

scientific article published on January 1981

The natural history of neoplasia. Newer insights into an old problem ⬇️

scientific article (publication date: November 1977)

The natural history of neoplastic development:The relation of experimental models to human cancer ⬇️

scientific article published on March 15, 1982

The ornithine aminotransferase gene in gyrate atrophy of the retina: analysis of expression and gross structure of this gene in cultured fibroblasts

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The oxidation of glycolic acid by a liver enzyme

scientific article (publication date: September 1954)

The phenotypic stability of altered hepatic foci: effect of the short-term withdrawal of phenobarbital and of the long-term feeding of purified diets after the withdrawal of phenobarbital

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The phenotypic stability of altered hepatic foci: effects of withdrawal and subsequent readministration of phenobarbital.

scientific article published on December 1986

The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.

scientific article published on 24 August 2008

The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: Transforming growth factor α expression as a marker for the stage of progression ⬇️

scientific article published on June 29, 1995

The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital

scientific article published on September 1985

The regulation of 4 forms of tyrosine aminotransferase in adult and developing rat liver.

scientific article published in September 1971

The regulation of beta-hydroxy-beta-methylglutaryl coenzyme A reductase in Morris hepatomas 5123C, 7800, and 9618A.

scientific article

The regulation of ornithine aminotransferase synthesis by glucagon in the rat ⬇️

scientific article published on May 1, 1976

The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding ⬇️

scientific article published on April 1, 1975

The role of hormones in glucose repression in rat liver

scientific article published on 01 January 1969

The role of receptors in multistage carcinogenesis

scientific article published on December 1995

The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat.

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The selectivity and stoicheiometry of membrane binding sites for polyribosomes, ribosomes and ribosomal subunits in vitro ⬇️

scientific article published on March 1, 1975

The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver

scientific article published on October 1985

The stability of events in the natural history of neoplasia ⬇️

scientific article published on December 1, 1977

The stability of the neoplastic state: introduction ⬇️

scientific article published on December 1, 1977

The stages of initiation and promotion in hepatocarcinogenesis

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The synthesis and degradation of rat liver and kidney fructose bisphosphatase in Vivo ⬇️

scientific article published on May 1, 1979

The tamoxifen controversy--clinical chemopreventive agent and experimental carcinogen

scientific article published on February 1995

The translational inhibitor cycloheximide represses growth factor depletion-induced apoptosis in an alb-SV40T transgenic rat liver cell line

scientific article published on June 1996

Three-dimensional reconstruction from serial sections in PC-Windows platform by using 3D_Viewer.

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Transcriptional control of ornithine aminotransferase synthesis in rat kidney by estrogen and thyroid hormone

scientific article published on 01 February 1984

Transcriptional regulation and localization of the tissue-specific induction of epoxide hydrolase by lead acetate in rat kidney

scientific article published on 01 March 1991

Transcriptional regulation of c-myc during chemically induced differentiation of HL-60 cultures

scientific article published on 01 February 1985

Transgene expression and repression in transgenic rats bearing the phosphoenolpyruvate carboxykinase-simian virus 40 T antigen or the phosphoenolpyruvate carboxykinase-transforming growth factor-alpha constructs

scientific article published on July 1999

Transgenic hepatocarcinogenesis in the rat

scientific article published in August 1994

Translational and pretranslational control of ornithine aminotransferase synthesis in rat liver ⬇️

scientific article published on May 25, 1983

Translational regulatory mechanisms in neoplasia in vivo

scientific article published on January 1, 1976

Transport of labelled compounds in control and cystic-fibrosis cells in vitro.

scientific article

Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase III trials N9741 and N9841.

scientific article published on 12 December 2011

Treatment of neuroendocrine cancer metastatic to the liver: the role of ablative techniques.

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Triggering the cellular change to neoplasia ⬇️

scientific article published on April 1, 1984

Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis ⬇️

scientific article published on January 1, 1991

Tumor-promoting barbiturates act on DNA repair of cultured hepatocytes

scientific article published in February 1986

Turnover of 3'-polyadenylate-containing RNA in livers from aged, partially hepatectomized, neonatal, and Morris 5123C hepatoma-bearing rats

scientific article published on 01 May 1980

U.S.-Japan Cooperative Cancer Research Program Conference. Glutathione S-transferase and carcinogenesis

scientific article published in November 1988

US pivotal studies of irinotecan in colorectal carcinoma

scientific article published on August 1, 1998

Ultrastructural and biochemical characteristics of endoplasmic reticulum fractions of the Morris 7800 and Reuber H-35 hepatomas

scientific article published on 01 July 1970

Ultrastructure of adult rat hepatocytes cultured on floating collagen membranes ⬇️

scientific article published on June 1, 1978

Unscheduled DNA synthesis in cells from N-2-fluorenylacetamide-induced hyperplastic nodules of rat liver maintained in a primary culture system ⬇️

scientific article published on 01 December 1975

Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes ⬇️

scientific article published on 01 July 1978

Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancer

scientific article published on 01 August 2007

Ureteral obstruction in cancer patients: a qualitative study

scientific article published on 22 June 2015

Use of KW-2189, a DNA minor groove-binding agent, in patients with hepatocellular carcinoma: a north central cancer treatment group (NCCTG) phase II clinical trial

scientific article published on 01 January 2007

Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations

scientific article published in April 1986

Use of primary cultures of adult rat hepatocytes on collagen gel-nylon mesh to evaluate carcinogen-induced unscheduled DNA synthesis

scientific article published in September 1980

Use of rat liver altered focus models for testing chemicals that have completed two-year carcinogenicity studies

scientific article

Variability in the oral bioavailability of all-trans-retinoic acid

scientific article published on 01 June 1993

Variation of hepatic malic enzyme capacity with hepatoma susceptibility in mice of different genotypes

scientific article published on 01 September 1972

Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741.

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Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma

scientific article published on 3 November 2017

all-trans retinoic acid: a dose-seeking study in solid tumors

scientific article published on 01 December 1993

alpha 2 micro-Globulin in the rat. The regulation of the appearance of multiple forms in vivo and in primary cultures of adult hepatocytes ⬇️

scientific article published on October 10, 1979

p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers

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γ-Glutamyltranspeptidase-positive (GGT+) hepatocytes from carcinogen-treated rats isolated by magnetic beads ⬇️

scientific article published on July 1, 1991

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