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List of works by Linda M. Sargent

A life cycle approach to engineered nanomaterial toxicity to provide context to potential health effects ⬇️

abstract published in 2017

Accumulation of ubiquitin and sequestosome-1 implicate protein damage in diacetyl-induced cytotoxicity

journal article published in 2016

Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats

journal article published in 2004

Altered ubiquitin expression in the airways of diacetyl-exposed mice ⬇️

abstract published in 2014

Amplification and deletion of mouse chromosome 4 in lung cancer ⬇️

conference abstract published in 2007

Amplification of mouse chromosome 1 in lung adenocarcinoma cell strains ⬇️

conference abstract published in 2005

Amplification of mouse chromosome 4 in chemically induced and invasive mouse lung adenocarcinoma ⬇️

abstract published in 2012

An evaluation of genotoxicity from as-produced and post-production modification of multi-walled carbon nanotubes ⬇️

abstract published in 2016

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat ⬇️

scientific article published on June 1, 1991

Capillary electrophoresis analysis of affinity to assess carboxylation of multi-walled carbon nanotubes

journal article published in 2018

Carbon nanotube uptake changes the biomechanical properties of human lung epithelial cells in a time-dependent manner

journal article published in 2015

Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains

journal article published in 2008

Comparative cytogenetics of mouse and human lung adenocarcinoma

abstract published in 2002

Comparative genotoxicity of fibrous particles: carbon nanofibers, single-walled carbon nanotubes, and asbestos ⬇️

abstract published in 2011

Comparison of cancer cell lines by karyotype and comparative genomic hybridization ⬇️

abstract published in 2002

Comparison of established cell lines at different passages by karyotype and comparative genomic hybridization

journal article published in 2004

Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat.

scientific article published on January 1989

Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression

scientific article published on July 1996

Detection of three novel translocation and specific common chromosomal break sites in malignant melanoma by spectral karyotyping

journal article published in 2001

Diacetyl-induced respiratory and olfactory toxicity in mice: influence of ubiquitination, gender, and dicarbonyl/L-xylulose reductase gene knockout ⬇️

abstract published in 2013

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

journal article published in 2012

Dose response of multi-walled carbon nanotube-induced lung tumors ⬇️

abstract published in 2017

Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans

journal article published in 2017

Exposure to carbon nanotubes leads to changes in the cellular biomechanics

journal article published in 2013

Genetic alterations in mouse lung adenocarcinoma: comparable changes in human lung adenocarcinoma ⬇️

conference abstract published in 2008

Genetic changes as biomarkers of mouse lung adenocarcinoma: comparison to human

conference abstract published in 2007

Genetic engineering and molecular technology

book or book chapter published in 2000

Genotoxicity and carcinogenic potential of carbon nanomaterials

chapter published in 2016

Genotoxicity from as-produced and post-production modified multi-walled carbon nanotubes ⬇️

abstract published in 2017

Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos?

journal article published in 2011

Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses

journal article published in 2014

Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses ⬇️

abstract published in 2012

Genotoxicity of multiwalled carbon nanotubes ⬇️

abstract published in 2013

Genotoxicity of pristine, heat-treated, and nitrogen-doped multi-walled carbon nanotubes at occupationally relevant doses ⬇️

abstract published in 2016

In vitro chromosome damage due to PCB interactions

scientific article published on 01 September 1989

In vivo toxicity assessment of occupational components of the carbon nanotube life cycle to provide context to potential health effects

journal article published in 2017

Increased gene Ccpy number may alter E2F1 activity in melanoma growth ⬇️

conference abstract published in 2003

Increased gene copy number may alter E2F1 activity in melanoma growth

abstract published in 2003

Increased gene copy number of the transcription factor E2F1 in malignant melanoma

journal article published in 2006

Induction of aneuploidy by single walled carbon nanotubes ⬇️

abstract published in 2009

Induction of aneuploidy by single-walled carbon nanotubes

journal article published in 2009

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.

scientific article

Induction of mitotic spindle aberrations by occupationally relevant doses of single-walled carbon nanotubes ⬇️

abstract published in 2010

Interactive cytogenetic effects on rat bone-marrow due to chronic ingestion of 2,5,2',5' and 3,4,3',4' PCBs

scientific article

Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat

scientific article published on 01 July 1996

Lessening genotoxicity using nitrogen-doping of multiwalled carbon nanotubes ⬇️

abstract published in 2015

Mechanisms in cyclophosphamide induction of cytogenetic damage in human lymphocyte cultures

scientific article published on 01 December 1987

Microscale exoglycosidase processing and lectin capture of glycans with phospholipid assisted capillary electrophoresis separations

journal article published in 2011

Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

journal article published in 2019

Modeling the influence of carbon nanotube and nanofiber physicochemical properties on key molecular initiating events and functional endpoints using epithelial, macrophage, and fibroblast cell models ⬇️

abstract published in 2020

Mosaic ring 12p and total anomalous pulmonary venous return

journal article published in 2004

Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor ⬇️

scientific article published on 01 January 1991

Multiwalled carbon nanotube-induced lung tumors ⬇️

abstract published in 2013

Nanoparticulate pathology ⬇️

conference proceedings item published in 2011

Nanoparticulates

chapter published in 2013

Nanotechnology: toxicologic pathology

journal article published in 2013

Nanotoxicology—A Pathologist’s Perspective ⬇️

scientific article published on December 14, 2010

Non-random chromosomal changes in high and low invasive tumor cells derived from early passage mouse lung adenocarcinoma cell cultures ⬇️

conference abstract published in 2002

Non-random chromosomal changes in high- and low-invasive tumor cells derived from early passage mouse lung adenocarcinoma cell strains ⬇️

conference abstract published in 2006

Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities

journal article published in 2020

Ploidy and karyotype of hepatocytes isolated from enzyme-altered foci in two different protocols of multistage hepatocarcinogenesis in the rat.

scientific article published in February 1989

Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver

scientific article published on February 1992

Positional approaches to cancer genetics

book or book chapter published in 2003

Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects

journal article published in 2010

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

journal article published in 2014

Relationship between in vivo carcinogenicity and human risk to carbon nanotubes ⬇️

abstract published in 2014

Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease

scientific article

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

journal article published in 2018

Role of polychlorinated biphenyl exposure in the progression of neoplasia ⬇️

book or book chapter published in 2001

Silica carcinogenicity analysis in a susceptible mouse model ⬇️

conference abstract published in 2006

Silica carcinogenicity in a susceptible mouse model ⬇️

abstract published in 2007

Single-walled carbon nanotube-induced mitotic disruption ⬇️

scientific article published on December 8, 2011

Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma ⬇️

journal article published in 2002

Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms ⬇️

scientific article published on August 15, 1997

Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo.

scientific article published in May 1991

Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats

scientific article published in July 1994

The initiation-promotion-progression model of rat hepatocarcinogenesis

scientific article published on January 1993

The occupational life cycle of MWCNT: toxicity evaluation from as-produced to post-production modifications and composites ⬇️

abstract published in 2016

The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis

journal article published in 2009

Thinking small: new approaches for evaluating the toxicologic pathology of nanotechnology products ⬇️

conference proceedings item published in 2013

Towards elucidating the effects of purified MWCNTs on human lung epithelial cells

journal article published in 2014

Toxicities associated with the occupational life cycle of MWCNT ⬇️

abstract published in 2016

Toxicological evaluation of carbon nanotubes from a lifecycle perspective ⬇️

abstract published in 2016

Understanding carbon nanotube genotoxicity ⬇️

abstract published in 2011

Understanding nanotechnology: an emerging challenge for the toxicologic pathologist ⬇️

abstract published in 2014

Understanding the variable drivers of toxicity for the broad class of carbon nanotubes and nanofibers from US facilities ⬇️

abstract published in 2020

mRNAs and miRNAs in whole blood associated with MWCNT-induced lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma following inhalation exposure in mice ⬇️

abstract published in 2015

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice

journal article published in 2016

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