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List of works by Vernon E Walker

1,3-Butadiene metabolite 1,2,3,4 diepoxybutane induces DNA adducts and micronuclei but not t(9;22) translocations in human cells

scientific article published on 15 August 2019

1,3-Butadiene, CML and the t(9:22) translocation: A reality check

scientific article published on 19 May 2015

1,3-Butadiene: Biomarkers and application to risk assessment

scientific article

1,3-butadiene: cancer, mutations, and adducts. Part III: In vivo mutation of the endogenous hprt genes of mice and rats by 1,3-butadiene and its metabolites

scientific article published on 01 March 2000

A model for the formation and removal of hemoglobin adducts ⬇️

scientific article published on March 1, 1992

A mouse model for the study of in vivo mutational spectra: Sequence specificity of ethylene oxide at the hprt locus ⬇️

scientific article published on July 1, 1993

Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene

scientific article published on 26 July 2006

Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile

scientific article published on 12 June 2020

Analysis of DNA Adducts and Mutagenic Potency and Specificity in Rats Exposed to Acrylonitrile

scientific article published on 12 June 2020

Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene

scientific article published in December 2004

Antiretroviral activity of aminothiols, WR2721 and WR1065.

scientific article

Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

scientific article

Biomarkers in toxicology and risk assessment: informing critical dose-response relationships

scientific article published on 28 December 2007

Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide.

scientific article

Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species

scientific article

Characterization of Hprt mutations in cDNA and genomic DNA of T-cell mutants from control and 1,3-butadiene-exposed male B6C3F1 mice and F344 rats

scientific article published on January 2004

Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene

scientific article published in April 2010

Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats ⬇️

scientific article published on 01 June 1998

Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane

scientific article published on 01 January 2000

Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen

scientific article published on 01 January 1998

Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice

scientific article published in January 1999

Determination of 7-(2-oxoethyl)guanine and N2,3-ethenoguanine in DNA hydrolysates by HPLC

scientific article published on 01 January 1989

Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene

scientific article published on 6 March 2007

Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene

scientific article (publication date: June 2010)

Frequencies of micronucleated reticulocytes, a dosimeter of DNA double-strand breaks, in infants receiving computed tomography or cardiac catheterization

scientific article

Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice.

scientific article published in October 1996

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

scientific article published on April 2007

Genotoxicity of 1,3-butadiene and its epoxy intermediates.

scientific article published on August 2009

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

scientific article

HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene

scientific article published on 25 April 2007

Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions ⬇️

scientific article published on January 15, 1998

Hprt mutant frequencies in splenic T-cells of male F344 rats exposed by inhalation to propylene

scientific article

Hprt mutant frequency and p53 gene status in mice chronically exposed by inhalation to benzene

scientific article published on 24 December 2009

Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation

scientific article published on 22 June 2020

In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue

scientific article

In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue

scientific article

In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure ⬇️

scientific article published on August 14, 1997

Intraperitoneal Administration of Coumarin Causes Tissue-Selective Depletion of Cytochromes P450 and Cytotoxicity in the Olfactory Mucosa ⬇️

scientific article published on September 1, 1997

Isotope Dilution nanoLC/ESI+-HRMS3 Quantitation of Urinary N7-(1-Hydroxy-3-buten-2-yl) Guanine Adducts in Humans and Their Use as Biomarkers of Exposure to 1,3-Butadiene

scientific article published on 20 December 2016

Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers

scientific article published on 01 June 2003

Low-dose radiation and genotoxic chemicals can protect against stochastic biological effects

scientific article published on July 2004

Macromolecular adducts of ethylene oxide: a literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation

scientific article

Measurement of plasma or urinary metabolites and Hprt mutant frequencies following inhalation exposure of mice and rats to 3-butene-1,2-diol

scientific article published on 12 February 2007

Mechanistic basis for nonlinear dose-response relationships for low-dose radiation-induced stochastic effects

scientific article published on January 2003

Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir

scientific article published in April 2004

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

scientific article published in April 2007

Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger

scientific article published on January 2002

Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation

scientific article

Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia

scientific article

Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide

scientific article

Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene

scientific article published on 01 July 1999

Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents

scientific article published in September 1999

Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice ⬇️

scientific article published on August 15, 1992

Molecular dosimetry of ethylene oxide: formation and persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice

scientific article published on 01 August 1992

Monitoring exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin.

scientific article published in December 1994

Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

scientific article

Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene

scientific article published in June 2001

Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats.

scientific article published in August 1999

Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells

scientific article published on 10 June 2006

Mutagenicity of stereochemical configurations of 1,3-butadiene epoxy metabolites in human cells.

scientific article published on June 2010

Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats

scientific article published on 01 August 1999

Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations

scientific article published on April 2007

Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.

scientific article

Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea ⬇️

scientific article published on September 1, 1992

N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides.

scientific article published on 7 November 2006

NanoHPLC-nanoESI(+)-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to subppm levels of 1,3-butadiene

scientific article published on 26 January 2012

Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs

scientific article published in September 2004

Persistence and Repair of Bifunctional DNA Adducts in Tissues of Laboratory Animals Exposed to 1,3-Butadiene by Inhalation ⬇️

scientific article published on April 13, 2011

Persistence of N7-(2,3,4-trihydroxybutyl)guanine adducts in the livers of mice and rats exposed to 1,3-butadiene.

scientific article published in March 1999

Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidine

scientific article published in January 2004

Plasma and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs

scientific article published on 01 April 2007

Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol

scientific article published on 11 May 2005

Quantitative analysis of 1,3-butadiene-induced DNA adductsin vivo andin vitro using liquid chromatography electrospray ionization tandem mass spectrometry ⬇️

scientific article published on 01 April 1998

Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice

scientific article

Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

scientific article

Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea

scientific article published on 01 December 1999

Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells

scientific article published on April 2007

Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitors

scientific article published on 01 April 2007

The Viracept-EMS case: impact and outlook

scientific article published in November 2009

The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity

scientific article published on 9 February 2007

The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium

scientific article published on 29 March 2013

The stress response resolution assay. II. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium

scientific article published on 29 March 2013

Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacI transgenic mice

scientific article published on 01 January 1999

Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats

scientific article

Transplacental mutagenicity of N-ethyl-N-nitrosourea at the hprt locus in T-lymphocytes of exposed B6C3F1 mice

scientific article published in January 2001

Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity

scientific article published in April 2007

Using DNA and hemoglobin adducts to improve the risk assessment of butadiene

scientific article

V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development

scientific article published in October 2006

VDJ recombinase-mediated TCR β locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development

scientific article published on August 2012

Vinyl chloride-induced DNA adducts. II: Formation and persistence of 7-(2'-oxoethyl)guanine and N2,3-ethenoguanine in rat tissue DNA.

scientific article published in August 1990

WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication

scientific article

Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

scientific article published in November 2000

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