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List of works by Alex B. Burgin

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1

scientific article

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

scientific article

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

scientific article

A two-drug model for etoposide action against human topoisomerase IIalpha

scientific article

Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues

scientific article

Artificial Neural Networks Trained to Detect Viral and Phage Structural Proteins ⬇️

scientific article published on August 23, 2012

Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases

scientific article

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10

scientific article

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer

scientific article

Corrections to Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography.

scientific article published on 12 February 2010

DNA ligation catalyzed by human topoisomerase II alpha

scientific article

Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.

scientific article

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

scientific article

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography †

scientific article

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

scientific article

Functional analysis of the C-terminal domains of the site-specific recombinases XerC and XerD.

scientific article

Gene Composerin a structural genomics environment ⬇️

scientific article published on August 13, 2011

Gene composer: database software for protein construct design, codon engineering, and gene synthesis

scientific article

Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism

scientific article

Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

scientific article published on 24 July 2008

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

scientific article

Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis ⬇️

scientific article published on February 5, 1992

Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent.

scientific article

Mechanisms of camptothecin resistance by human topoisomerase I mutations

scientific article

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha

scientific article published on September 2009

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

scientific article

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

scientific article

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

scientific article

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

scientific article published on October 2016

Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease

scientific article

Plasmid RK2 ParB protein: purification and nuclease properties.

scientific article published on October 1999

Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage

scientific article

Regulation of site-specific recombination by the C-terminus of lambda integrase

scientific article published on December 2002

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases ⬇️

scientific article published on February 3, 2012

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

scientific article published on 27 June 2012

Selection, design, and characterization of a new potentially therapeutic ribozyme

scientific article

Small Molecule Allosteric Modulators of Phosphodiesterase 4 ⬇️

scientific article published on January 1, 2011

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

scientific article published on 19 December 2019

Some of the most interesting CASP11 targets through the eyes of their authors

scientific article

Structural basis for the design of selective phosphodiesterase 4B inhibitors

scientific article

Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex

scientific article

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

scientific journal article

Structure and function of a cyanophage-encoded peptide deformylase

scientific article

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

scientific article published in April 2005

Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.

scientific article published on 15 October 2004

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

scientific article

Suicide substrates reveal properties of the homology-dependent steps during integrative recombination of bacteriophage lambda

scientific article published in November 1995

Synthesis and use of DNA containing a 5'-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases

scientific article

The excision of intervening sequences from Salmonella 23S ribosomal RNA

scientific article

The scale of demographic heterogeneity in a population of Peromyscus leucopus.

scientific article

Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase)

scientific article published on 01 January 2006

Uncoupling the chemical steps of telomere resolution by ResT.

scientific article published on 23 May 2005

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

scientific article

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV ⬇️

scientific article published on February 7, 2011

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

scientific article published on March 2009

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

scientific article published on 05 March 2008

Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester

scientific article

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