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List of works by Barbara A Weir

"Lineage addiction" in human cancer: lessons from integrated genomics

scientific article published on January 2005

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

scientific article published on 3 October 2017

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

scientific article

Absolute quantification of somatic DNA alterations in human cancer

scientific article

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

scientific article published on 31 October 2005

Allele-specific amplification in cancer revealed by SNP array analysis

scientific article

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

scientific article

Amplification of chromosomal segment 4q12 in non-small cell lung cancer

scientific article

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

scientific article

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

scientific article published on 31 May 2017

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

Cancer vulnerabilities unveiled by genomic loss

scientific article

Characterizing genomic alterations in cancer by complementary functional associations

scientific article published on 18 April 2016

Characterizing the cancer genome in lung adenocarcinoma

scientific article

Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

scientific article

Clinical, epidemiologic and bacteriologic observations of an outbreak of methicillin-resistant Staphylococcus aureus at a large community hospital

scientific article published on 01 September 1976

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

scientific article

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

scientific article

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Defining a Cancer Dependency Map.

scientific article

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

scientific article

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

scientific article

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

Genomic approaches to lung cancer

scientific article published on July 2006

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

scientific article

Highly parallel identification of essential genes in cancer cells

scholarly article

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

scientific article published on July 2005

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

scientific article published on 18 November 2015

In Situ Evidence of KRAS Amplification and Association With Increased p21 Levels in Non–Small Cell Lung Carcinoma

article

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

scientific article published on 02 January 2014

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

scientific article

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

scientific article published on 31 January 2014

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

scientific article

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

scientific article published on 11 February 2016

Major copy proportion analysis of tumor samples using SNP arrays

scientific article

Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe

scientific article

Next-generation characterization of the Cancer Cell Line Encyclopedia

scientific article published on 08 May 2019

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

scientific article

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

scientific article published on 10 April 2017

PLASQ: a generalized linear model-based procedure to determine allelic dosage in cancer cells from SNP array data

scientific article

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

scientific article

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

scientific article (publication date: 15 April 2009)

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

scientific article published on 18 May 2009

Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer

scientific article

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

scientific article published on 4 September 2013

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

scientific article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Somatic alterations in the human cancer genome

scientific article

Somatic mutations affect key pathways in lung adenocarcinoma

scientific article

Standard Specimens for Stain Calibration: Application to Romanowsky-Giemsa Staining ⬇️

scientific article published on January 1, 1990

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

scientific article

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

scientific article

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

scientific article published on 13 June 2013

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

scientific article

TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival

scientific article published in January 2009

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

scientific article published on August 2012

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

scientific article published on 18 October 2016

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer

scientific article

The landscape of somatic copy-number alteration across human cancers

scientific article

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.

scientific article published on 19 February 2007

Towards patient-based cancer therapeutics

scientific article

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

scientific article

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