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List of works by Stephan R. Targan

2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).

scientific article published on 15 May 2008

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

scientific article published in April 2002

6-thioguanine can cause serious liver injury in inflammatory bowel disease patients

scientific article (publication date: August 2003)

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

scientific article published on July 2016

A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study

scientific article published on 01 November 2018

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition

scientific article

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn's Disease

scientific article

A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn’s disease ⬇️

scientific article published on May 21, 2011

A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.

scientific article published on 22 July 2004

A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease

scientific article published in August 1990

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

scientific article

A genome-wide search identifies potential new susceptibility loci for Crohn's disease

scientific article published on November 1999

A new syndrome of Crohn's disease and pachydermoperiostosis in a family

scientific article published on 01 January 1997

A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews

scientific article

A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis

scientific article published on 21 August 2007

A pilot study of adalimumab in infliximab-allergic patients

scientific article published on 01 July 2004

A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis

scientific article published on July 2010

A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis

scientific article published in May 2009

A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosis

scientific article published on 4 June 2007

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

scientific article published on 09 August 2016

A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies

scientific article published on 07 January 2019

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease ⬇️

scientific article published on December 15, 1997

A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

scientific article

A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells

scientific article published on 01 October 1999

A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables

scientific article published on 15 November 2015

A147 RESPONSE AND REMISSION AFTER 16 WEEKS OF USTEKINUMAB– AN ALL PATIENTS ANALYSIS FROM THE UNITI CROHN’S STUDIES

A85 EFFICACY AND SAFETY OF DOSE ADJUSTMENT AND DELAYED RESPONSE TO USTEKINUMAB IN MODERATE–SEVERE CROHN’S DISEASE: RESULTS FROM THE IM-UNITI MAINTENANCE STUDY

ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease

scientific article

ANTI-TUMOR NECROSIS FACTOR-α THERAPY IN CROHNʼS DISEASE: A MAGIC BULLET FINALLY HITS ITS MARK

scientific article published on January 1, 1996

Abatacept for Crohn's Disease and Ulcerative Colitis ⬇️

scientific article published on April 12, 2012

Activation of human NKCC by moderate exercise: increased frequency of NK cells with enhanced capability of effector--target lytic interactions ⬇️

scientific article published on 01 August 1981

Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12.

scientific article

Age of diagnosis influences serologic responses in children with Crohn's disease: a possible clue to etiology?

scientific article published on May 2009

Altered intestinal ACE2 levels are associated with inflammation, severe disease and response to anti-cytokine therapy in IBD

scientific article published on 02 November 2020

American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006.

scientific article published on July 2007

An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial

scientific article published on 01 May 2001

An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease

scientific article published in December 1999

An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy

scientific article published in August 2001

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients

scientific article published on 01 April 1997

Analysis of sequential substages of the natural killer cell lethal hit

scientific article published on 01 January 1985

Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis ⬇️

scientific article published on October 9, 2012

Anti-CD2O chimeric monoclonal antibody (rituximab) treatment of immune-mediated thrombocytopenia associated with Crohn's disease

scientific article published on 01 February 2003

Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis

scientific article

Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.

scientific article published in May 2007

Anti-neutrophil cytoplasmic antibodies in ulcerative colitis

scientific article published on 01 June 1991

Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis

scientific article published on 10 May 2006

Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease

scientific article

Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.

scientific article

Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease

scientific article published on 01 December 2006

Antineutrophil Cytoplasmic Antibody Subtypes in Children and Adolescents After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis ⬇️

scientific article published on 01 April 1998

Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis

scientific article published on 01 May 1995

Assessing Health Status in Inflammatory Bowel Disease Using a Novel Single-Item Numeric Rating Scale ⬇️

scientific article published on December 19, 2012

Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts.

scientific article

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease

scientific article published on 8 April 2017

Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease

scientific article published in February 2004

Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: results of a pilot study

scientific article published on 01 May 1996

B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.

scientific article published on 16 November 2012

Bacterial flagellin is a dominant antigen in Crohn disease.

scientific article published on May 2004

Biologic therapy of inflammatory bowel disease.

scientific article

Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma ⬇️

scientific article published on November 24, 2010

Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis

scientific article published on 18 April 2008

CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile

scientific article (publication date: July 2003)

CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.

scientific article published in August 2001

CD161 DEFINES EFFECTOR T CELLS THAT EXPRESS LIGHT AND RESPOND TO TL1A-DR3 SIGNALING.

scientific article published on March 2011

CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells ⬇️

scientific article published on 01 May 2003

CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation

scientific article published on 01 June 1999

CD56 marks an effector T cell subset in the human intestine

scientific article published on 01 May 2007

Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn

scientific article

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice

scientific article published on 14 July 2011

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor

scientific article published on 10 May 2016

Certolizumab pegol

scientific article published on 01 August 2008

Challenges in IBD Research: updating the scientific agendas

scientific article published on 01 May 2003

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans

scientific article

Clinical Factors Associated with the Development of Crohn's Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch-anal Anastomosis

scientific article published on 01 June 2016

Clinical utility of serodiagnostic testing in suspected pediatric inflammatory bowel disease

scientific article published on 01 March 2001

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients

scientific article

Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis

scientific article published on 5 October 2015

Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.

scientific article

Colonoscopy during an attack of severe ulcerative colitis

scholarly article by F Shanahan et al published September 1991 in The American Journal of Gastroenterology

Colorectal cancer screening and surveillance in Crohn's colitis ⬇️

scientific article published on 05 February 2012

Combination of genetic and quantitative serological immune markers are associated with complicated Crohnʼs disease behavior ⬇️

scientific article published on March 9, 2011

Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease

scientific article published on August 2010

Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease

scientific article published on August 2015

Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis ⬇️

scientific article published on January 11, 2011

Constitutive TL1A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis ⬇️

scientific article published on December 2, 2011

Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists

scientific article published on 04 September 2008

Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

correction of a scientific article; published on 30 May 2019

Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch-specific complications

scientific article published on May 1999

Crohn's ileitis after liver transplantation from a living related donor with Crohn's disease

scientific article published in September 2004

Current limitations of IBD treatment: where do we go from here?

scientific article published on August 2006

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD

scientific article

Cytotoxic lymphocytes in human intestinal mucosa

Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial

scientific article published on 7 April 2006

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

scientific article published on 12 January 2017

Defective generation of tetanus-specific antibody-producing B cells after in vivo immunization of Crohn's disease and ulcerative colitis patients

scientific article published on 01 June 1985

Defective memory B cell formation in patients with inflammatory bowel disease following tetanus toxoid booster immunization.

scientific article published in October 1987

Defects in mucosal immunity leading to ulcerative colitis

scientific article

Definition of a secondary target cell trigger during natural killer cell cytotoxicity: possible role of phospholipase A2

scientific article published on 01 December 1987

Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA.

scientific article published on May 1999

Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction

scientific article published on 28 November 2007

Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD

scientific article published on 20 February 2020

Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease ⬇️

scientific article published on 01 October 1998

Differences in the management of Crohn's disease among experts and community providers, based on a national survey of sample case vignettes

scientific article published on October 2007

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis

scientific article published on 27 January 2016

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

scientific article published on 23 October 2020

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

scientific article

Distinct Methylation of IFNG in the Gut

scientific article

Distinct associations of HLA class II genes with inflammatory bowel disease.

scientific article published in March 1993

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen ⬇️

scientific article published on November 1, 1995

Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis?

scientific article

Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease?

scientific article published in May 2012

Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes

scientific article published in April 2005

Double-Balloon Endoscopy in Crohn Disease: A Tertiary Referral Center Experience

scientific article published on 06 November 2020

Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.

scientific article

Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease

scientific article

Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine or azathioprine therapy for Crohn's disease

scientific article published on 01 February 2000

Elevated flagellin-specific immunoglobulins in Crohn's disease

scientific article published on 23 September 2004

Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitis

scientific article published in October 2005

Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study.

scientific article published on 26 October 2013

Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease

scientific article published on December 2008

Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.

scientific article published on 29 December 2017

Enhanced neutrophil chemiluminescence in familial Mediterranean fever

scientific article

Enhanced peripheral blood T-cell cytotoxicity in inflammatory bowel disease.

scientific article published in January 1989

Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression

scientific article published in November 2004

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

scientific article published on 01 March 2019

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

Erratum: Corrigendum: The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose and How to Predict Respo

article

Erratum: Corrigendum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

scholarly article published in Nature Genetics

Erratum: Genome-wide association identifies multiple ulcerative colitis susceptibility loci

scholarly article published in Nature Genetics

Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2)

scientific article published on 5 June 2013

Evaluation of Serologic Disease Markers in a Population-Based Cohort of Patients with Ulcerative Colitis and Crohn's Disease

article

Evidence for involvement of serine proteases in the late stages of the natural killer cell lytic reaction

scientific article published on 01 December 1986

Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development

scientific article published on 9 January 2008

Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease.

scientific article published in August 2008

Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa

scientific article published in November 2004

Expression of a novel autoantibody defined by the VH3-15 gene in inflammatory bowel disease and Campylobacter jejuni enterocolitis

scientific article published on October 1994

Extended Dose Ipilimumab with a Peptide Vaccine: Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma ⬇️

scientific article published on November 24, 2010

Factors predictive of response to cyclosporin treatment for severe, steroid-resistant ulcerative colitis

scientific article

Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews

scientific article

Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease

scientific article

Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease

scientific article

Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis

scientific article published on 18 December 2007

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

scientific article

Functional signaling of membrane-bound TL1A induces IFN-gamma expression

scientific article published on 18 April 2010

Future Therapeutic Approaches for Inflammatory Bowel Diseases ⬇️

scientific article published on May 1, 2011

Future biologic targets for IBD: potentials and pitfalls

scientific article published on February 2010

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

scientific article

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease

scientific article published on June 2009

Genetic markers may predict disease behavior in patients with ulcerative colitis

scientific article

Genetic predictors of medically refractory ulcerative colitis

scientific journal article

Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

scientific article

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease

scientific article

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

scientific article published on 28 September 2016

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

scientific article

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

scientific article

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

scientific article

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

scientific article

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

scientific article published on 5 January 2018

HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations

scientific article (publication date: March 2000)

HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses ⬇️

scientific article published on January 1, 2013

Hermansky-Pudlak syndrome: an immunologic assessment of 15 cases

scientific article published on December 1988

High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy

scientific article published in April 2004

High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis

scientific article

High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease

scientific article

High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females

scientific article published on March 2009

High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study

scientific article published in August 2004

High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis ⬇️

scientific article published on April 1, 1995

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

Human Monoclonal Antibodies against Clostridium difficile Toxins A and B Inhibit Inflammatory and Histologic Responses to the Toxins in Human Colon and Peripheral Blood Monocytes ⬇️

scientific article published on April 29, 2013

Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function

scientific article

Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk

scientific article published on 20 August 2014

Human mucosal T-cell cytotoxicity.

scientific article published in April 1988

Human mucosal cytotoxic effector cells

scientific article published on 01 June 1987

Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis

scientific article published on 13 March 2020

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein

scientific article

IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion

scientific article

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

scientific article

IL23R haplotypes provide a large population attributable risk for Crohn's disease

scientific article published on September 2008

Identification of a novel bacterial sequence associated with Crohn's disease

scientific article published on July 2000

Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease

scientific article

Identification of a prodromal period in Crohn's disease but not ulcerative colitis

scientific article

Identification of histone H1 as a cognate antigen of the ulcerative colitis-associated marker antibody pANCA.

scientific article published on February 2000

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups

scientific article published on 01 August 2019

Immunologic mechanisms in intestinal diseases

scientific article published in June 1987

Immunopathogenesis of inflammatory bowel disease

scientific article published on 01 January 2008

Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease

scientific article

Increased immune reactivity predicts aggressive complicating Crohn's disease in children

scientific article published on 10 July 2008

Increased neutrophil receptors for and response to the proinflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease.

scientific article

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome

Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach

scientific article published on July 2007

Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study

scientific article

Infliximab for the treatment of fistulas in patients with Crohn's disease

scientific article

Infliximab in the treatment of medically refractory indeterminate colitis

scientific article published on 01 October 2003

Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study.

scientific article

Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease

scientific article published on 01 April 2001

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

scientific article

Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes

scientific article published on 01 April 1986

Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease.

scientific article published in January 2004

Insights into IBD Pathogenesis

scientific article

Insights into TL1A and IBD Pathogenesis ⬇️

scientific article published on January 1, 2011

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

preprint published 25 September 2016

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

scientific article

Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease

scientific article

Intestinal immunity and inflammation: recent progress

scientific article

Introductory Words About TL1A/DR3 ⬇️

scientific article published on 01 January 2011

K562 killing by K, IL 2-responsive NK, and T cells involves different effector cell post-binding trigger mechanisms

LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine

scientific article published in July 2004

LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling

scientific article

Lack of an association between polymorphisms of the T-cell receptor alpha-chain and ulcerative colitis

scientific article published in November 1989

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

article

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics

scientific article published on 01 October 2018

Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses

scientific article

Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation

scientific article

Long-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy.

scientific article published on 24 May 2018

Long-term outcomes of thalidomide in refractory Crohn's disease

scientific article published on 15 December 2014

MAGI2 genetic variation and inflammatory bowel disease

scientific article published on January 2009

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models

scientific article published on 05 March 2019

Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics

scientific article

Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study ⬇️

scientific article published on November 29, 2012

Mast cell and neuroendocrine cytoplasmic autoantigen(s) detected by monoclonal pANCA antibodies

scientific article

Measurement of tumor necrosis factor alpha mRNA in small numbers of cells by quantitative polymerase chain reaction

scientific article published on 01 January 1993

Medical treatment of inflammatory bowel disease.

scientific article

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells

scientific article published on November 2009

Microbiota activation and regulation of innate and adaptive immunity

scientific article

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

scientific article published on 11 December 2018

Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids

scientific article published on 30 December 2020

Modulation of ongoing human immunoglobulin synthesis by natural killer cells

scientific article published on 01 June 1987

Molecular Approaches to the Role of the Microbiota in Inflammatory Bowel Disease

scientific article published on 01 August 2006

Molecular cloning of a Bacteroides caccae TonB-linked outer membrane protein identified by an inflammatory bowel disease marker antibody

scientific article

Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.

scientific article published on 17 July 2008

Molecular patterns in human ulcerative colitis and correlation with response to infliximab

scientific article published on December 2014

Morbidity of subtotal colectomy in patients with severe ulcerative colitis unresponsive to cyclosporin

scientific article published in December 1995

Multidimensional Prognostic Risk Assessment Identifies Association Between IL12B Variation and Surgery in Crohn’s Disease ⬇️

scientific article published on July 1, 2013

Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease

scientific article

Multiple activating and repressive cis -promoter regions regulate TNFSF15 expression in human primary mononuclear cells ⬇️

scientific article published on April 30, 2013

Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease

scientific article published in September 2002

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

scientific article published on 27 January 2017

NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells ⬇️

scientific article published on 01 February 1984

NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.

scientific article published on 10 November 2006

Natalizumab Induction and Maintenance Therapy for Crohn's Disease

scientific article

Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial

scientific article published on 21 March 2007

Neutrophil autoantibodies as disease markers for ulcerative colitis

scientific article published on January 1991

Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity ⬇️

scholarly article by F Shanahan et al published August 1992 in Gastroenterology

Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis

scientific article

New enema treatments for inflammatory bowel disease

scientific article published on 01 March 1988

Nonbloody Diarrhea but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo Crohn's Disease After Ileal Pouch-anal Anastomosis for Ulcerative Colitis

scientific article published on 20 November 2015

O-001 A Multicenter, Double-Blind, Placebo-Controlled Phase3 Study of Ustekinumab, a Human IL-12/23P40 mAB, in Moderate-Service Crohnʼs Disease Refractory to Anti-TFNα

OC-005 A Multicenter, Double-Blind, Placebo (PBO)-Controlled Ph3 Study of Ustekinumab (UST), A Human IL-12/23P40 MAB, in Moderate-Severe Crohn’s Disease (CD) Refractory to anti-TNFΑ: UNITI-1

Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits.

scientific article published on 8 October 2015

Oral mesalamine (Asacol) for mildly to moderately active ulcerative colitis. A multicenter study

scientific article published in September 1991

Outcome of cytomegalovirus infections in patients with inflammatory bowel disease

scientific article published in July 2001

Outcomes with Anti-Tumour Necrosis Factor-Alpha Therapy and Serology in Patients with Denovo Crohn's Disease After Ileal Pouch Anal Anastomosis

scientific article

Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses.

scientific article published on 30 June 2006

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease

scientific article

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway

scientific article published on 02 March 2016

Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients

scientific article published on 01 September 1995

Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup

scientific article published in June 1996

Phage display cloning and characterization of an immunogenetic marker (perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis

scientific article

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

scientific article

Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease

scientific article published in March 2007

Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases

scientific article published on 21 May 2018

Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

scientific article published on September 1, 2001

Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation

scientific article

Pouchitis disease course after orthotopic liver transplantation in patients with primary sclerosing cholangitis and an ileal pouch-anal anastomosis

scientific article published on 01 December 1995

Pre-Pouch Ileitis is Associated with Development of Crohn's Disease-Like Complications and Pouch Failure

scientific article published on 10 December 2020

Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study

scientific article published on May 2007

Preoperative wireless capsule endoscopy does not predict outcome after ileal pouch-anal anastomosis

scientific article published in March 2010

Prevalence and Associations of Avascular Necrosis of the Hip in a Large Well-characterized Cohort of Patients With Inflammatory Bowel Disease

scientific article published on 01 January 2019

Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis

scientific article

Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study

scientific article

Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine

scientific article published on 30 November 2010

Recent advances in IBD pathogenesis: genetics and immunobiology

scientific article published on December 2008

Recent understanding of IBD pathogenesis: implications for future therapies

scientific article published on November 2006

Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn′s disease

scientific article published on 23 April 2020

Relative Preservation of Treg Function in Tl1A-TG Mice Under Germ-Free Condition

Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines

scientific article

Rigorous histopathological assessment of the colectomy specimen in patients with inflammatory bowel disease unclassified does not predict outcome after ileal pouch-anal anastomosis

scientific article published on 15 September 2009

Role of antineutrophil cytoplasmic antibodies in an ethnically distinct population: Korean patients with ulcerative colitis.

scientific article published in November 1995

Role of the CD45 (T-200) molecule in anti-CD3-triggered T cell-mediated cytotoxicity

scientific article

SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS.

scientific article published on March 2013

Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab

scientific article published on 01 January 2005

Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis

scientific article published in November 1995

Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens

scientific article published in September 2002

Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype

scientific article published on 01 December 2004

Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation

scientific article

Serologic, Genetic, and Clinical Associations with Increased Healthcare Resource Utilization in Inflammatory Bowel Disease.

scientific article

Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression

scientific article

Split‐dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6‐MMP metabolism ⬇️

scientific article published on July 11, 2012

State of the art: IBD therapy and clinical trials in IBD.

scientific article

Studies on the mechanism of the human natural killer cell lethal hit: a new method for rapid physical isolation of lethally hit K562 targets and inhibition of cytolysis by reduced temperature or trypsin

scientific article published on 01 January 1984

Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells

scientific article published on 23 September 2011

Sulfasalazine and salicylate-induced exacerbation of ulcerative colitis

scientific article published on 01 August 1987

Sulfasalazine-Induced Exacerbation of Ulcerative Colitis ⬇️

scientific article published on February 18, 1982

Surgical Outcome of Ileal Pouch—Anal Anastomosis When Used Intentionally for Well-Defined Crohnʼs Disease ⬇️

scientific article published on January 1, 2013

Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis

scientific article published in October 1996

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

scientific article published on 07 May 2008

TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice

scientific article published on 26 November 2017

TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets

scientific article published on 27 March 2010

TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells

scientific article published in June 2004

TLR8-mediated activation of human monocytes inhibits TL1A expression

scientific article

TNFRSF1B Is Associated with ANCA in IBD.

scientific article

TNFSF15 is an ethnic-specific IBD gene

scientific article

The "lazy" NK cells of Chediak-Higashi syndrome.

scientific article published on June 1983

The CD8+ Leu-7+ subset of T cells in Crohn's disease: distinction between cytotoxic and covert suppressor functions

scientific article

The Effects of Ustekinumab on Health-related Quality of Life in Patients With Moderate to Severe Crohn's Disease

scientific article published on 01 July 2018

The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?

scientific article

The Presence of Anti-Neutrophil Antibodies Reflects Clinical and Genetic Heterogeneity Within Inflammatory Bowel Disease ⬇️

scientific article published on 01 February 1998

The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells

scientific article

The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction

scientific article published on 12 October 2016

The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice.

scientific article published on 03 July 2012

The effect of 6-mercaptopurine on natural killer-cell activities in Crohn's disease

scientific article published on 01 May 1985

The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery

scientific article published on March 2015

The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease.

scientific article published in July 2004

Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine

scientific article

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

scientific article

Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease

scientific article

Treatment With Infliximab Is Associated With Increased Markers of Bone Formation in Patients With Crohn??s Disease

scientific article published on 01 January 2006

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

scientific article published on 01 January 1991

Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6.

scientific article

Ulcerative colitis and total alopecia in a mother and her son

scientific article published on 01 April 1993

Ulcerative colitis-linked antineutrophil cytoplasmic antibody in the cotton-top tamarin model of colitis

scientific article published in May 1992

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

scientific article

Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers

scientific article

Use of animal models in elucidating disease pathogenesis in IBD.

scientific article

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

scientific article (publication date: 17 November 2016)

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

scientific article published on 01 September 2019

Ustekinumab induction and maintenance therapy in refractory Crohn's disease

scientific article

Ustekinumab is effective and safe for ulcerative colitis through 2 years of maintenance therapy

scientific article published on 21 October 2020

Variants in ZNF365 isoform D are associated with Crohn's disease ⬇️

scientific article published on January 21, 2011

Weeding out the facts: the reality about cannabis and Crohn's disease

scientific article published on 20 November 2013

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