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List of works by David A Barbie

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

article

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing

scientific article published on 21 September 2018

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

scholarly article

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

scientific article

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

scientific article published on 26 June 2018

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

scientific article published on 11 April 2016

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

scientific article published on 3 November 2017

Characterizing genomic alterations in cancer by complementary functional associations

scientific article published on 18 April 2016

Clonal Selection Drives NF-κB Activation in Recurrent Nasopharyngeal Carcinoma

scientific article published on 01 December 2019

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

scientific article published on 15 August 2019

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

scientific article published on 14 November 2016

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 November 2018

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 January 2019

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

scientific article published on 10 January 2020

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

scientific article

Doxycycline: new tricks for an old drug.

scientific article published in August 2015

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

scientific article published on 05 November 2020

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

scientific article published on 22 March 2021

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

scientific article published on 3 November 2017

Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment.

scientific article published on 19 August 2016

Functional genomics and cancer drug target discovery.

scientific article published on June 2010

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

scientific article published on 27 August 2018

Highly parallel identification of essential genes in cancer cells

scholarly article

Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade

scientific article published on 05 May 2020

Inflammation as a driver and vulnerability of KRAS mediated oncogenesis

scientific article published on 10 June 2016

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

scientific article

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

scientific article published on 14 September 2020

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

scientific article published on 26 May 2015

Mechanisms of resistance to immune checkpoint inhibitors

scientific article published on 2 January 2018

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

scientific article

MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

scientific article published on 16 January 2017

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer

scientific article published on 3 November 2017

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

scientific article

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

scientific article

Nuclear organization of DNA replication in primary mammalian cells.

scientific article

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit

scientific article published on January 2004

Nuclear tumor suppressors in space and time.

scientific article

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

scientific article published on 01 September 2018

Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.

scientific article published on 30 July 2018

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure

scientific article published on 04 August 2018

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

scientific article published on 29 October 2019

Plasma inflammatory cytokines and survival of pancreatic cancer patients

scientific article published on 25 April 2018

RASA1/NF1 mutant lung cancer: Racing to the clinic?

scientific article published on 17 January 2018

RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest

scientific article

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

scientific article

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

scientific article

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

scientific article published on 7 February 2015

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

scientific article published on 12 June 2019

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

scientific article published on February 2016

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1 ⬇️

scientific article published on February 28, 2013

Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer

article

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer

scientific article published on 13 April 2017

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

scientific article

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

scientific article published on 13 June 2013

Systemic mastocytosis: current classification and novel therapeutic options.

scientific article published on October 2006

TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability

scientific article published on 01 March 2020

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

scientific article

Targeting cytokine networks in KRAS-driven tumorigenesis

scientific article published on 13 June 2014

Targeting pathways downstream of KRAS in lung adenocarcinoma

scientific article

Targeting the mutant p53 secretome

scientific article published on 01 January 2021

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

scientific article

The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.

scientific article

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy

scientific article published on 01 December 2018

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

scientific article published on 01 January 2020

Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.

scientific article published on 31 January 2017

Tumor cGAMP Awakens the Natural Killers

scientific article published on 01 October 2018

Tumor-Derived cGAMP Regulates Activation of the Vasculature

scientific article published on 04 September 2020

Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis

scientific article published on 21 September 2020

Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer

scientific article published on 07 February 2020

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

scientific article

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