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List of works by Dorothy E Vatner

'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption'.

scientific article published on 13 October 2013

A Food and Drug Administration-Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion

scientific article published on 3 March 2016

A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion

scientific article published on 22 May 2018

Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain

scientific article published on 01 February 2002

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

scientific article

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy

scientific article published on 16 October 2006

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance

scientific article published on 2 March 2015

Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress.

scientific article published on 24 December 2008

Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.

scientific article published on 26 April 2013

Adenylyl cyclase type 5 protein expression during cardiac development and stress.

scientific article published on 04 September 2009

Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates

scientific article published on 12 May 2003

Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha

scientific article published on 01 February 2007

Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction

scientific article published on 01 January 2002

An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p

scientific journal article

Antioxidant defense and protection against cardiac arrhythmias: lessons from a mammalian hibernator (the woodchuck).

scientific article published on 28 February 2018

Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function ⬇️

scientific article published on December 10, 2010

Apoptosis predominates in nonmyocytes in heart failure

scientific article published on 22 May 2009

Arterial Pressure Monitoring in Mice

scientific article

Autophagy in chronically ischemic myocardium.

scientific article

Autophagy in ischemic preconditioning and hibernating myocardium

scientific article published on 23 July 2009

Autophagy: a novel protective mechanism in chronic ischemia.

scientific article

Best anesthetics for assessing left ventricular systolic function by echocardiography in mice

scientific article published on 10 April 2015

Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis

scientific article

Caloric restriction reduces growth of mammary tumors and metastases

scientific article

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy.

scientific article published on 20 January 2013

Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism

scientific article published on 20 June 2008

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

scientific article

Cardiomyocyte overexpression of the α1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning.

scientific article published on 3 February 2012

Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure

scientific article

Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy

scientific article published on 17 November 2003

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

scientific article published on 17 October 2012

Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction.

scientific article published on 22 July 2009

Disruption of adenylyl cyclase type 5 mimics exercise training

scientific article published on 8 September 2017

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress

scientific article published on 24 September 2007

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.

scientific article published on 6 August 2003

Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade

scientific article

Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes

scientific article published on 5 March 2009

Echocardiography in Mice ⬇️

scientific article published on March 1, 2011

Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload

scientific article

Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes

scientific journal article

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

scientific article published on 14 April 2018

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates

scientific article published on 18 February 2016

Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys

scientific article

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload

scientific article published on 28 August 2009

Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart

scientific article published on 28 August 2003

Healthful Aging Mediated by Inhibition of Oxidative Stress

scientific article published on 19 October 2020

Heart Rate and Electrocardiography Monitoring in Mice

scientific article published on March 2011

Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress

scientific article published on 29 April 2019

Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart

scientific article published on 21 July 2007

Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension

scientific article published on 24 May 2013

Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection

scientific article published on 7 April 2015

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor

scientific article published on 19 April 2007

Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals

scientific article published on 12 February 2004

Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus

scientific article published on 01 April 2003

Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.

scientific article published on 16 September 2003

Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates

scientific article published on 30 July 2007

Mechanisms of Increased Vascular Stiffness Down the Aortic Tree in Aging, Pre-Menopausal Female Monkeys

scientific article published on 12 June 2020

Mechanisms of sex differences in exercise capacity

scientific article published on 24 April 2019

Metabolomic analysis of two different models of delayed preconditioning

scientific article

MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths

scientific article

Models of longevity (calorie restriction and AC5 KO): result of three bad hypotheses

scientific article published on October 2012

Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.

scientific article published on September 2010

Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window.

scientific article

Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis

scientific article

Myocardial apoptosis in heart disease: does the emperor have clothes?

scientific article published on 4 April 2016

Myocardial ischemic protection in natural mammalian hibernation

scientific article

Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy

scientific article published on 01 September 2003

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

scientific article

Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs

scientific article published on 26 October 2006

Overexpressed cardiac Gsalpha in rabbits

scientific article published on 05 May 2006

Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling

scientific article

Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart

scientific article

Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy.

scientific article published on 28 July 2005

Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.

scientific article published on 15 May 2003

Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase ⬇️

scientific article published on February 11, 2011

Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition

scientific article published on 22 August 2006

Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase

scientific article

Program of cell survival underlying human and experimental hibernating myocardium

scientific article published on 8 July 2004

Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha

scientific article

Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.

scientific article published in February 2004

Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax

scientific article

Rats are Protected from the Stress of Chronic Pressure Overload as Compared with Mice

scientific article published on 25 March 2020

Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning

scientific article published on 20 October 2008

Reply to "Letter to the Editor: Mechanisms of sex differences in exercise capacity"

scientific article published on 01 January 2020

Reply to "Letter to the editor: When what you see may not be what you get: prudent considerations of anesthetics for murine echocardiography".

scientific article published on June 2015

Reply to: "Letter to the editor: Ketamine-only versus isoflurane effects on murine cardiac function: comparison at similar depths of anesthesia?".

scientific article

Response to Letter to the Editor on "Does Vidarabine Mediate Cardioprotection via Inhibition of AC5?".

scientific article published in August 2016

Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia ⬇️

scientific article published on August 11, 2011

Secreted Frizzled Protein 3 Is A Novel Cardioprotective Mechanism Unique to the Clinically Relevant 4th Window of Ischemic Preconditioning

scientific article published on 18 December 2020

Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis

scientific article published on 26 June 2020

Sex differences in myocardial infarction and rupture

scientific article published on 21 August 2007

Sex-specific regulation of gene expression in the aging monkey aorta

scientific article published on 01 April 2007

Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging

scientific article published on 15 July 2010

Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension ⬇️

scientific article published on January 1, 2012

Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging ⬇️

scientific article published on June 26, 2012

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

scientific article

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation

scientific article published on 17 July 2003

Type 5 adenylyl cyclase disruption increases longevity and protects against stress

scientific article published on 01 July 2007

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

scientific article

Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway

scientific article published on 27 March 2013

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