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List of works by Gary K Owens

"Attack of the Clones": Commonalities Between Cancer and Atherosclerosis

scientific article

5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo

scientific article

5-Lipoxygenase pathway in experimental abdominal aortic aneurysms

scientific article

A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.

scientific article

A new single-injury model of balloon angioplasty in cholesterol-fed rabbits: beneficial effect of hirudin and comparison with double-injury model

scientific article published on July 1, 1997

A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics

scientific article

A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements

scientific article

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression

scientific article

ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development

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ANG II- or AVP-induced increases in protein synthesis are not dependent on autocrine secretion of PDGF-AA.

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Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response ⬇️

scientific article published on August 25, 1993

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

scientific article

Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms

scientific article

All-trans-retinoic acid limits restenosis after balloon angioplasty in the focally atherosclerotic rabbit : a favorable effect on vessel remodeling

scientific article published on 01 January 2000

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells

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Angiotensin II stimulates increased protein synthesis, not increased DNA synthesis, in intact rat aortic segments, in vitro

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Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor

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Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta

scientific article published on April 1, 1992

Angiotensin II–Induced Stimulation of Smooth Muscle α-Actin Expression by Serum Response Factor and the Homeodomain Transcription Factor MHox ⬇️

scientific article published on October 1, 1997

Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: time course and effect of hirudin

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Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.

scientific article

Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation ⬇️

scientific article published on October 11, 2011

Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling

scientific article

CArG elements control smooth muscle subtype-specific expression of smooth muscle myosin in vivo

scientific article

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis

scientific article published on 18 January 2018

Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease

scientific article

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

scientific article published on 15 June 2020

Combinatorial Control of Smooth Muscle–Specific Gene Expression ⬇️

scientific article published on March 6, 2003

Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells

scientific article

Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury

scientific article

Conditional mouse models to study developmental and pathophysiological gene function in muscle.

scientific article

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.

scientific article

Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo

scientific article

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

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Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap

scientific article

Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

scientific article published on February 2016

Critical role of TNF-α in cerebral aneurysm formation and progression to rupture

scientific article

Derivation of contractile smooth muscle cells from embryonic stem cells.

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Detection of histone modifications at specific gene loci in single cells in histological sections

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Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation.

scientific article

Developmental changes in isoactin expression in rat aortic smooth muscle cells in vivo. Relationship between growth and cytodifferentiation

scientific article published on October 1986

Differential effect of platelet-derived growth factor- versus serum-induced growth on smooth muscle alpha-actin and nonmuscle beta-actin mRNA expression in cultured rat aortic smooth muscle cells

scientific article

Early plus delayed hirudin reduces restenosis in the atherosclerotic rabbit more than early administration alone: potential implications for dosing of antithrombin agents

scientific article

Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits

scientific article

Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation ⬇️

scientific article published on January 15, 1992

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

scientific article

Excitation-transcription coupling in arterial smooth muscle.

scientific article

Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements

scientific article

Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells

scientific article

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

scientific article published on 12 October 2020

Genetic and Pharmacologic Disruption of Interleukin-1β Signaling Inhibits Experimental Aortic Aneurysm Formation ⬇️

scientific article published on January 3, 2013

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

scientific article

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

Hyperplastic growth response of vascular smooth muscle cells following induction of acute hypertension in rats by aortic coarctation.

scientific article

Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms.

scientific article

Interaction of CArG Elements and a GC-rich Repressor Element in Transcriptional Regulation of the Smooth Muscle Myosin Heavy Chain Gene in Vascular Smooth Muscle Cells ⬇️

scientific article published on November 21, 1997

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

scientific article published on 23 July 2018

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms

scientific article

Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation

scientific article published on 15 October 2020

KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation

scientific article

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

scientific article published on 18 September 2017

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

scientific article

Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression.

scientific article

Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids

scientific article

L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.

scientific article

LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury

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Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model

scientific article

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation

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Lost in transdifferentiation.

scientific article

Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor

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Mechanisms of angiotensin II- and arginine vasopressin-induced increases in protein synthesis and content in cultured rat aortic smooth muscle cells. Evidence for selective increases in smooth muscle isoactin expression

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Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells

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Molecular determinants of vascular smooth muscle cell diversity

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Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury.

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Molecular regulation of smooth muscle cell differentiation.

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Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells

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Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actin

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Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes

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Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

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Myosin light chain kinase knockout

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Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity

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Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice

scientific article published on 24 October 2019

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice

scientific article

Nuclear proteins bind a cis-acting element in the smooth muscle alpha-actin promoter

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Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension

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Origin of neointimal smooth muscle: we've come full circle

scientific article published on 01 December 2006

Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program

scientific article

Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro

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Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration

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PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

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PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.

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PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation

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PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.

scientific article

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation

scientific article

PlaqOmics Leducq Fondation Trans-Atlantic Network

scientific article published on 01 April 2019

Platelet-derived growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells

scientific article published in March 1990

Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes

scientific article

Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters

scientific article published on 20 September 2006

Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation

scientific article published on December 1, 1992

Platelet-derived growth factor-induced destabilization of smooth muscle alpha-actin mRNA.

scientific article

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

scientific article

Predictors of luminal narrowing by neointima after angioplasty in atherosclerotic rabbits ⬇️

scientific article published on December 1, 1997

Programming smooth muscle plasticity with chromatin dynamics

scientific article

Reconciling Smooth Muscle Cell Oligoclonality and Proliferative Capacity in Experimental Atherosclerosis

scientific article published in December 2016

Recruitment of serum response factor and hyperacetylation of histones at smooth muscle-specific regulatory regions during differentiation of a novel P19-derived in vitro smooth muscle differentiation system

scientific article

Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5' and first intron promoter regions

scientific article

Response to letter regarding article, "Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysm".

scientific article

Revealing the Origins of Foam Cells in Atherosclerotic Lesions

scientific article published on 01 May 2019

Reversible permeabilization. A novel technique for the intracellular introduction of antisense oligodeoxynucleotides into intact smooth muscle

scientific article

Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells

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Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention

scientific article

Similarities and differences in smooth muscle alpha-actin induction by TGF-beta in smooth muscle versus non-smooth muscle cells

scientific article

Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5′-Flanking and First Intronic DNA Sequence ⬇️

scientific article published on May 4, 1998

Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation

scientific article

Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex

scientific article

Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins

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Smooth muscle cell phenotypic switching in atherosclerosis

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Smooth muscle cell plasticity: fact or fiction?

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Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

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Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression

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Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

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Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation

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Smooth muscle phenotypic modulation is an early event in aortic aneurysms

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Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury

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Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle

scientific article

Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype

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Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression

scientific article published on 23 November 2005

Substitution of the Degenerate Smooth Muscle (SM) α-Actin CC(A/T-rich)6GG Elements with c-fos Serum Response Elements Results in Increased Basal Expression but Relaxed SM Cell Specificity and Reduced Angiotensin II Inducibility ⬇️

scientific article published on April 3, 1998

TNF-α Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Pathology ⬇️

scientific article published on July 17, 2013

The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology

scientific article published on 28 September 2017

The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

scientific article published on 17 July 2020

The actin associated protein palladin is important for the early smooth muscle cell differentiation

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The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies

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The smooth muscle alpha-actin gene promoter is differentially regulated in smooth muscle versus non-smooth muscle cells

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The smooth muscle myosin heavy chain gene exhibits smooth muscle subtype-selective modular regulation in vivo

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Therapeutic implications of estrogen for cerebral vasospasm and delayed cerebral ischemia induced by aneurysmal subarachnoid hemorrhage

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Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis

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Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

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Thrombin-induced mitogenesis in cultured aortic smooth muscle cells requires prolonged thrombin exposure

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Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA.

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Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells.

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Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture

scientific article

Vascular Smooth Muscle Cells in Atherosclerosis

scientific article published on February 2016

Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2.

scientific article published on 19 September 2005

Vascular smooth muscle cells in cerebral aneurysm pathogenesis

scientific article

WD Repeat-containing Protein 5, a Ubiquitously Expressed Histone Methyltransferase Adaptor Protein, Regulates Smooth Muscle Cell-selective Gene Activation through Interaction with Pituitary Homeobox 2 ⬇️

scientific article published on April 28, 2011

Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels.

scientific article

ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation

scientific article published on 01 January 2019

alpha-Thrombin induces transforming growth factor-beta1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor

scientific article

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