List of works - Brian R Wamhoff

"FRNKly, smooth muscle, I don't give a CArG!": a novel mechanism for smooth muscle cell differentiation

scientific article published on December 2008

5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo

scientific article

A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.

scientific article

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

scientific article published on 20 August 2015

Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration

scientific article

Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.

scientific article

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

scientific article

Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes

scientific article published on 11 May 2020

Chromatin Immunoprecipitation (ChIP): Revisiting the Efficacy of Sample Preparation, Sonication, Quantification of Sheared DNA, and Analysis via PCR ⬇️

scientific article published on October 25, 2011

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis

scientific article

Conditional mouse models to study developmental and pathophysiological gene function in muscle.

scientific article

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.

scientific article

Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo

scientific article

Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells

scientific article published on 01 March 2019

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

scientific article published on 8 December 2016

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

scientific article

Drug-induced steatohepatitis

article

Excitation-transcription coupling in arterial smooth muscle.

scientific article

Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine

scientific article

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

scientific article published on 19 June 2017

FTY720 promotes local microvascular network formation and regeneration of cranial bone defects

scientific article

Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles

scientific article

Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report

scientific article

Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease

scientific article published on 29 August 2019

Genome-Wide Microarray Analyses Identify the Protein C Receptor as a Novel Calcineurin/Nuclear Factor of Activated T Cells–Dependent Gene in Vascular Smooth Muscle Cell Phenotypic Modulation ⬇️

scientific article published on November 1, 2011

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression ⬇️

scientific article published on April 28, 2011

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells

scientific article published on 27 April 2016

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow

scientific article

Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine

scientific article published in February 2003

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

scientific article

Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells

scientific article

Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells

scientific article published in November 2002

Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force ⬇️

scientific article published on October 1, 2012

Intravascular ultrasound detection and delivery of molecularly targeted microbubbles for gene delivery ⬇️

scientific article published on July 1, 2012

L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.

scientific article

Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

scientific article

Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.

scientific article

Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation ⬇️

scientific article published on April 23, 2011

Lost in transdifferentiation.

scientific article

Microbubble-mediated intravascular ultrasound imaging and drug delivery

scientific article published on September 2015

Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells

scientific article

Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype

scientific article

Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes

scientific article

NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration ⬇️

scientific article published on August 3, 2012

Non-alcoholic fatty liver disease (NAFLD) models in drug discovery

scientific article

Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation

scientific article

Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia

scientific article

Organotypic systems in drug metabolism and toxicity: challenges and opportunities ⬇️

scientific article published on May 26, 2012

Origin of neointimal smooth muscle: we've come full circle

scientific article published on 01 December 2006

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

scientific article

Porcine model of diabetic dyslipidemia: insulin and feed algorithms for mimicking diabetes mellitus in humans.

scientific article published in February 2003

RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth

scientific article published on 06 February 2007

Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes

scientific article

Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles

scientific article

Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).

scientific article

Selective Activation of Sphingosine 1-Phosphate Receptors 1 and 3 Promotes Local Microvascular Network Growth ⬇️

scientific article published on November 9, 2010

Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype

scientific article

Targeted Gene Transfection from Microbubbles into Vascular Smooth Muscle Cells Using Focused, Ultrasound-Mediated Delivery ⬇️

scientific article published on September 1, 2010

The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.

scientific article

Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5) ⬇️

scientific article published on October 12, 2011

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

scientific article published on 25 November 2015

Upregulation of intermediate-conductance Ca2+-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle

scientific article published on 23 June 2006

List of works by Brian R Wamhoff

"FRNKly, smooth muscle, I don't give a CArG!": a novel mechanism for smooth muscle cell differentiation

5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo

A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration

Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes

Chromatin Immunoprecipitation (ChIP): Revisiting the Efficacy of Sample Preparation, Sonication, Quantification of Sheared DNA, and Analysis via PCR ⬇️

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis

Conditional mouse models to study developmental and pathophysiological gene function in muscle.

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.

Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo

Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

Drug-induced steatohepatitis

Excitation-transcription coupling in arterial smooth muscle.

Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

FTY720 promotes local microvascular network formation and regeneration of cranial bone defects

Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles

Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report

Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease

Genome-Wide Microarray Analyses Identify the Protein C Receptor as a Novel Calcineurin/Nuclear Factor of Activated T Cells–Dependent Gene in Vascular Smooth Muscle Cell Phenotypic Modulation ⬇️

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression ⬇️

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow

Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells

Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells

Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force ⬇️

Intravascular ultrasound detection and delivery of molecularly targeted microbubbles for gene delivery ⬇️

L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.

Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.

Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation ⬇️

Lost in transdifferentiation.

Microbubble-mediated intravascular ultrasound imaging and drug delivery

Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells

Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype

Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes

NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration ⬇️

Non-alcoholic fatty liver disease (NAFLD) models in drug discovery

Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation

Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia

Organotypic systems in drug metabolism and toxicity: challenges and opportunities ⬇️

Origin of neointimal smooth muscle: we've come full circle

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

Porcine model of diabetic dyslipidemia: insulin and feed algorithms for mimicking diabetes mellitus in humans.

RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth

Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes

Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles

Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).

Selective Activation of Sphingosine 1-Phosphate Receptors 1 and 3 Promotes Local Microvascular Network Growth ⬇️

Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype

Targeted Gene Transfection from Microbubbles into Vascular Smooth Muscle Cells Using Focused, Ultrasound-Mediated Delivery ⬇️

The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.

Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5) ⬇️

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

Upregulation of intermediate-conductance Ca2+-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle