List of works - Akiyoshi Kakita

Aberration of the spliceosome in amyotrophic lateral sclerosis

scientific article published on 01 January 2014

Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study

scientific article published on 10 December 2019

Bunina bodies in motor and non-motor neurons revisited: a pathological study of an ALS patient after long-term survival on a respirator

scientific article published on 20 January 2014

C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS.

scientific article

Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication

scientific article published on 28 August 2008

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

scientific article published on 4 August 2016

Clinicopathologic Features of Two Patients With Sporadic Amyotrophic Lateral Sclerosis Who Maintained Communication Ability for Over 30 Years

scientific article published on 01 November 2018

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V).

scientific article published on 30 September 2016

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

scientific article published on 4 June 2013

Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death.

scientific article published on 8 May 2009

Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy.

scientific article published on February 2007

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease

scientific article published on November 2007

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

scientific article published on 5 March 2018

Familial amyotrophic lateral sclerosis with an I104F mutation in the SOD1 gene: Multisystem degeneration with neurofilamentous aggregates and SOD1 inclusions

scientific article published on 22 July 2016

Globular glial tauopathy Type II: Clinicopathological study of two autopsy cases

scientific article published on 15 January 2019

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.

scientific article published on 13 December 2013

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

scientific article published on 23 June 2016

Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation

scientific article published on 25 May 2018

Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

scientific article published on 02 June 2016

Loss of Motor Neurons Innervating Cervical Muscles in Patients With Multiple System Atrophy and Dropped Head.

scientific article published on 6 February 2018

Marinesco-Sjögren syndrome with atrophy of the brain stem tegmentum and dysplastic cytoarchitecture in the cerebral cortex

scientific article published on 11 April 2008

Multiplex families with multiple system atrophy

scientific article

Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: With Special Reference to Astrocytic Tau Pathology

scientific article

Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.

scientific article

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

scientific article published on 28 October 2019

Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43

scientific article published on 21 November 2011

Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations

scientific article published in August 2014

Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation

scientific article published on 01 February 2019

Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease

scientific article

Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy

scientific article published on 22 August 2019

Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene

scientific article published on 28 June 2013

Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology.

scientific article

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions

scientific article published on 15 May 2008

TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

scientific article

TDP-43 mutation in familial amyotrophic lateral sclerosis

scientific article published in April 2008

Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3

scientific article published on 01 October 2020

Variants associated with Gaucher disease in multiple system atrophy

scientific article

[Clinical and pathological spectrum of TDP-43 associated ALS]

scientific article published on 01 November 2010

[FTLD/ALS as TDP-43 proteinopathies]

scientific article published on 01 November 2010

List of works by Akiyoshi Kakita

Aberration of the spliceosome in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study

Bunina bodies in motor and non-motor neurons revisited: a pathological study of an ALS patient after long-term survival on a respirator

C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS.

Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

Clinicopathologic Features of Two Patients With Sporadic Amyotrophic Lateral Sclerosis Who Maintained Communication Ability for Over 30 Years

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V).

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death.

Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

Familial amyotrophic lateral sclerosis with an I104F mutation in the SOD1 gene: Multisystem degeneration with neurofilamentous aggregates and SOD1 inclusions

Globular glial tauopathy Type II: Clinicopathological study of two autopsy cases

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation

Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

Loss of Motor Neurons Innervating Cervical Muscles in Patients With Multiple System Atrophy and Dropped Head.

Marinesco-Sjögren syndrome with atrophy of the brain stem tegmentum and dysplastic cytoarchitecture in the cerebral cortex

Multiplex families with multiple system atrophy

Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: With Special Reference to Astrocytic Tau Pathology

Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43

Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations

Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation

Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease

Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy

Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene

Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology.

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions

TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

TDP-43 mutation in familial amyotrophic lateral sclerosis

Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3

Variants associated with Gaucher disease in multiple system atrophy

[Clinical and pathological spectrum of TDP-43 associated ALS]

[FTLD/ALS as TDP-43 proteinopathies]